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James Bown

Professor

  • 449 Citations
  • 13 h-Index
19982019

Research output per year

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Research Output

2019

Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis

Jones-Todd, C. M., Caie, P., Illian, J. B., Stevenson, B. C., Savage, A., Harrison, D. J. & Bown, J. L., 15 Apr 2019, In : Statistics in Medicine. 38, 8, p. 1421-1441 21 p.

Research output: Contribution to journalArticle

Open Access
File
39 Downloads (Pure)
2018

Engineering simulations as scientific instruments: a pattern language

Stepney, S., Polack, F. A. C., Alden, K., Andrews, P. S., Bown, J. L., Droop, A., Greaves, R. B., Read, M., Sampson, A. T., Timmis, J. & Winfield, A. F. T., 8 Nov 2018, Cham: Springer. 368 p.

Research output: Book/ReportBook

Narratives for drug design

Bown, J. & Goltsov, A., 24 Nov 2018, Narrating complexity. Walsh, R. & Stepney, S. (eds.). Cham: Springer, p. 253-268 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Unsupervised machine learning of integrated health and social care data from the Macmillan Improving the Cancer Journey service in Glasgow

Kang, K. L., Greer, M., Bown, J., Preston, J., Mabelis, J., Hepburn, L-A., Fisher, M., Falconer, R. E., McDermott, S. & Deed, S., 8 Nov 2018, In : British Journal of Cancer. 119, 1 p., 4.

Research output: Contribution to journalMeeting Abstract

Open Access
File
49 Downloads (Pure)
2017

A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT

Bown, J. L., Shovman, M., Robertson, P., Boiko, A., Goltsov, A., Mullen, P. & Harrison, D. J., 2 May 2017, In : Oncotarget. 8, p. 29657-29667 11 p.

Research output: Contribution to journalArticle

Open Access
File
55 Downloads (Pure)

Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002

Goltsov, A., Tashkandi, G., Langdon, S. P., Harrison, D. J. & Bown, J. L., 15 Jan 2017, In : European Journal of Pharmaceutical Sciences. 97, p. 170–181 12 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
101 Downloads (Pure)

NRF2 regulates HER1 signaling pathway to modulate the sensitivity of ovarian cancer cells to lapatinib and erlotinib

Hamza Kankia, I., Khalil, H. S., Langdon, S. P., Moult, P. R., Bown, J. L. & Deeni, Y. Y., 19 Dec 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 19 p., 1864578.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
44 Downloads (Pure)
2016

A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells

Khalil, H. S., Langdon, S. P., Goltsov, A., Soininen, T., Harrison, D. J., Bown, J. & Deeni, Y. Y., 15 Nov 2016, In : Oncotarget. 7, p. 75874-75901 28 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
47 Downloads (Pure)

Cancer systems biology

Bown, J. L., 20 Jul 2016, In : Journal of Biotechnology. 231, Suppl, p. S4 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access

NRF2 regulates HER2 and HER3 signaling pathway to modulate sensitivity to targeted immunotherapies

Khalil, H. S., Langdon, S. P., Kankia, I. H., Bown, J. L. & Deeni, Y. Y., Jan 2016, In : Oxidative Medicine and Cellular Longevity. 2106, 22 p., 4148791.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
44 Downloads (Pure)

Validation of a novel assay for cardiology drug screening using hESC-derived cardiomyocyte spheroids - “mini-hearts”

Zhelev, N., Kaske, R. & Bown, J. L., 10 Aug 2016, In : Journal of Biotechnology. 231, suppl, p. S108 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access
2015

Morphological analysis of cancer spheroids

Bown, J. L., Savage, A., Houston, A. N., Wilson, S., Khalil, H. S., Goltsov, A. & Deeni, Y. Y., 20 Aug 2015, In : Journal of Biotechnology. 208, suppl, p. S6 1 p.

Research output: Contribution to journalMeeting Abstract

Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells

Khalil, H. S., Goltsov, A., Langdon, S. P., Harrison, D. J., Bown, J. & Deeni, Y., 20 May 2015, In : Journal of Biotechnology. 202, p. 12-30 19 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
101 Downloads (Pure)

The targeting of epidermal growth factor family receptors (ERBBs) in ovarian cancer therapy

Deeni, Y. Y., Khalil, H. S., Goltsov, A., Soininen, T., Langdon, S. P., Harrison, D. J. & Bown, J. L., 20 Aug 2015, In : Journal of Biotechnology. 208, Suppl 20, p. S6-S7 2 p.

Research output: Contribution to journalMeeting Abstract

Twist and learn: interface learning in 3DOF exploration of 3D scatterplots

Shovman, M., Szymkowiak, A., Bown, J. L. & Scott-Brown, K. C., 18 Apr 2015, Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems. New York: Association for Computing Machinery (ACM), p. 313-316 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Understanding resistance mechanisms to PI3K/mTOR inhibitors in ovarian cancer model systems

Tashkandi, G., Goltsov, A., Mullen, P., Bown, J., Harrison, D. & Langdon, S., Jul 2015, In : Molecular Cancer Therapeutics. 14, 7, Suppl., p. B33 1 p.

Research output: Contribution to journalMeeting Abstract

Understanding tissue morphology: model repurposing using the CoSMoS process

Sampson, A. T., Bown, J. L., Khalil, H. S. & Deeni, Y. Y., 1 Mar 2015, In : Natural Computing. 14, 1, p. 109–128 20 p.

Research output: Contribution to journalArticle

Open Access
File
58 Downloads (Pure)
2014

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations

Goltsov, A., Langdon, S. P., Goltsov, G., Harrison, D. J. & Bown, J. L., 5 Feb 2014, In : Frontiers in Oncology. 4, 13, 14 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
45 Downloads (Pure)

Process-based vs. data-driven modelling of cancer cell behaviour

Bown, J. L., Idowu, M. A., Khalil, H. S., Goltsov, A., Deeni, Y., Zhelev, N., Langdon, S. P. & Harrison, D. J., Sep 2014, In : Journal of Biotechnology. 185, Suppl, p. S13-S13 1 p.

Research output: Contribution to journalMeeting Abstract

Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy

Goltsov, A., Deeni, Y. Y., Khalil, H. S., Soininen, T., Kyriakidis, S., Hu, H., Langdon, S. P., Harrison, D. J. & Bown, J. L., 10 Jun 2014, In : Cells. 3, 2, p. 563-591 29 p.

Research output: Contribution to journalSpecial issue

Open Access
File
47 Downloads (Pure)
2013

Characterising the tumour morphological response to therapeutic intervention: an ex vivo model

Savage, A., Katz, E., Eberst, A., Falconer, R. E., Houston, A. N., Harrison, D. J. & Bown, J. L., Jan 2013, In : Disease Models & Mechanisms. 6, 1, p. 252-260 9 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
40 Downloads (Pure)

Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer

Hu, H., Goltsov, A., Bown, J. L., Sims, A. H., Langdon, S. P., Harrison, D. J. & Faratian, D., Jan 2013, In : Cellular Signalling. 25, 1, p. 26-32 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Matrix-based analytical methods for recasting Jacobian models to power-law models

Idowu, M. A. & Bown, J. L., 2013, Proceedings of the eighth EUROSIM Congress on Modelling and Simulation, EUROSIM 2013, September 10-13, Cardiff, Wales. Al-Begain, K., Al-Dabass, D., Orsoni, A., Cant, R. & Zobel, R. (eds.). Los Alamitos, CA: IEEE Computer Society, p. 250-258 9 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

Idowu, M. A., Khalil, H. S., Bown, J. L. & Zhelev, N., 11 Dec 2013, In : BioDiscovery. 2013, 9, 32 p., 4.

Research output: Contribution to journalArticle

Open Access
File
58 Downloads (Pure)
2012

Engineering simulations for cancer systems biology

Bown, J. L., Andrews, P. S., Deeni, Y. Y., Goltsov, A., Idowu, M. A., Polac, F. A. C., Sampson, A. T., Shovman, M. & Stepney, S., Nov 2012, In : Current Drug Targets. 13, 12, p. 1560-1574 15 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
70 Downloads (Pure)

Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition

Goltsov, A., Faratian, D., Langdon, S. P., Mullen, P., Harrison, D. J. & Bown, J. L., Feb 2012, In : Cellular Signalling. 24, 2, p. 493-504 12 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
93 Downloads (Pure)

Matrix operations for the simulation and immediate reverse-engineering of time series data

Idowu, M. A. & Bown, J. L., 2012, Proceedings: 2012 14th International Conference on Modelling and Simulation. Al-Dabass, D., Orsoni, A. & Cant, R. (eds.). Piscataway, NJ: IEEE , p. 101-106 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File
3 Citations (Scopus)
53 Downloads (Pure)

The meaning of graphs: scatterplots as a test-bed for theories of object-hood

Shovman, M., Scott-Brown, K. C., Szymkowiak, A. & Bown, J. L., 2012, In : Gestalt theory. 34, 3/4, p. 381-398 18 p.

Research output: Contribution to journalArticle

Open Access
2011

Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition

Goltsov, A., Faratian, D., Langdon, S. P., Bown, J. L., Goryanin, I. & Harrison, D. J., Feb 2011, In : Cellular Signalling. 23, 2, p. 407-416 10 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
66 Downloads (Pure)

Linking individual behaviour to community scale patterns in fungi

Falconer, R. E., Bown, J. L., White, N. A. & Crawford, J. W., Feb 2011, In : Fungal Ecology. 4, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
65 Downloads (Pure)

Modelling of Healthcare Associated Infections: a study on the dynamics of pathogen transmission by using an individual-based approach

Milazzoa, L., Bown, J. L., Eberst, A., Phillips, G. & Crawford, J. W., Nov 2011, In : Computer Methods and Programs in Biomedicine. 104, 2, p. 260-265

Research output: Contribution to journalArticle

17 Citations (Scopus)

Towards an exact reconstruction of a time-invariant model from time series data

Idowu, M. A. & Bown, J. L., 23 Nov 2011, In : Journal of Computer Science and Systems Biology. 4, 4, 15 p.

Research output: Contribution to journalArticle

Open Access
File
65 Downloads (Pure)
2010

Information visualization and the arts-science-social science interface

Bown, J. L., Fee, K., Sampson, A. T., Shovman, M., Falconer, R. E., Goltsov, A., Issacs, J. P., Robertson, P., Scott-Brown, K. C. & Szymkowiak, A., 2010, Proceeding of the First International Conference on Intelligent Interactive Technologies and Multimedia: IITM 10. Association for Computing Machinery (ACM), p. 9-17 9 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Is visual search a high-level phenomenon? Evidence from structure perception in 3-D scatterplots

Shovman, M., Szymkowiak, A., Bown, J. L. & Scott-Brown, K. C., 1 Aug 2010, In : Perception. 39, 8, p. 1149-1150 2 p.

Research output: Contribution to journalMeeting Abstract

Modelling fungal colonies and communities: challenges and opportunities

Falconer, R. E., Bown, J. L., McAdam, E. V., Perez-Reche, P., Sampson, A. T., van den Bulcke, J., White, N. A. & Perez-Reche, F. J., Dec 2010, In : IMA Fungus. 1, 2, p. 155-159 5 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
38 Downloads (Pure)

Symbiotic cognitive networks: a proposal

Rasheed, T., Hart, E., Bown, J. L. & Falconer, R. E., Jul 2010, Artificial Immune Systems: 9th International Conference, ICARIS 2010, Edinburgh, UK, July 26-29, 2010: proceedings. Hart, E., McEwan, C., Timmis, J. & Hone, A. (eds.). Berlin: Springer-Verlag, p. 326-328 3 p. (Lecture Notes in Computer Science; vol. 6209).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)
2009

A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells

Clyde, R. G., Craig, A. L., Breed, L. D., Bown, J. L., Forrester, L., Vojtesek, B., Smith, G., Hupp, T. R. & Crawford, J. W., 6 Dec 2009, In : Journal of the Royal Society Interface. 6, 41, p. 1167-1177 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Changing the view: towards the theory of visualisation comprehension

Shovman, M., Szymkowiak, A., Bown, J. L. & Scott-Brown, K. C., Jul 2009, Proceedings: Information Visualisation IV 2009. Banissi, E., Stuart, L., Wyeld, T. G., Jern, M., Andrienko, G., Memon, N., Alhajj, R., Burkhard, R. A., Grinstein, G., Groth, D., Ursyn, A., Johansson, J., Forsell, C., Cvek, U., Trutschl, M., Marchese, F. T., Maple, C., Cowell, A. J. & Moere, A. V. (eds.). Los Alamitos, CA: IEEE , p. 135-138 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File
5 Citations (Scopus)
79 Downloads (Pure)
2008

A new paradigm for SpeckNets: inspiration from fungal colonies

Falconer, R. E., Bown, J. L., Hart, E. & Timmis, J., Oct 2008, Proceedings of the Second IEEE International Conference on Self-Adaptive and Self-Organizing Systems Workshops. Di Marzo Serugendo, G. & Gleizes, M-P. (eds.). Piscataway, NJ: IEEE , p. 90-95 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File
1 Citation (Scopus)
34 Downloads (Pure)

Dynamic emotional expression choreography: perception of naturalistic facial expressions

Sloan, R. J. S., Robinson, B., Cook, M. & Bown, J. L., Nov 2008, Inaugural SAND Academic Peer Reviewed Papers. Capey, M. N., Ip, B. & Blastland, F. E. (eds.). Swansea: Swansea Metropolitan University

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Modelling interactions in fungi

Falconer, R. E., Bown, J. L., White, N. A. & Crawford, J. W., Jun 2008, In : Journal of the Royal Society Interface. p. 603-615 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Use of 'pop-out' paradigm to test graph comprehension in a three-dimensional scatter plot

Shovman, M., Scott-Brown, K. C., Szymkowiak, A. & Bown, J. L., Aug 2008, In : Perception. 37, 1, p. 79-80 1 p.

Research output: Contribution to journalMeeting Abstract

21 Citations (Scopus)
2007

Biomass recycling: a key to efficient foraging by fungal colonies

Falconer, R. E., Bown, J. L., White, N. A. & Crawford, J. W., Sep 2007, In : Oikos. 116, 9, p. 1558-1568 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Consequences of intraspecific variation for the structure and function of ecological communities: Part 1. Model development and predicted patterns of diversity

Bown, J. L., Pachepsky, E., Eberst, A., Bausenwein, U., Millard, P., Squire, G. R. & Crawford, J. W., Oct 2007, In : Ecological Modelling. 207, 2-4, p. 264-276 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Consequences of intraspecific variation for the structure and function of ecological communities Part 2: inking diversity and function

Pachepsky, E., Bown, J. L., Eberst, A., Bausenwein, U., Millard, P., Squire, G. R. & Crawford, J. W., Oct 2007, In : Ecological Modelling. 207, 2-4, p. 277-285 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2006

The role of modelling in identifying drug targets for diseases of the cell cycle

Clyde, R. G., Bown, J. L., Hupp, T. R., Zhelev, N. & Crawford, J. W., Oct 2006, In : Journal of the Royal Society Interface. 3, 10, p. 617-627 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2005

Biomass recycling and the origin of phenotype in fungal mycelia

Falconer, R. E., Bown, J. L., White, N. A. & Crawford, J. W., 22 Aug 2005, In : Proceedings of the Royal Society B: Biological Sciences. 272, 1573, p. 1727-1734 8 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2002

The effects of fungal inoculum arrangement (scale and context) on emergent community development in an agar model system

Sturrock, C. J., Ritz, K., Samson, W. B., Bown, J. L., Staines, H. J., Palfreyman, J. W., Crawford, J. W. & White, N. A., Jan 2002, In : FEMS Microbiology Ecology. 39, 10, p. 9-16 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2001

Towards a general theory of biodiversity

Pachepsky, E., Crawford, J. W., Bown, J. L. & Squire, G., 19 Apr 2001, In : Nature. 410, 6831, p. 923-926 4 p.

Research output: Contribution to journalLetter

63 Citations (Scopus)