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James Bown

Professor

  • 453 Citations
  • 14 h-Index
19982019

Research output per year

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Research Output

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Article
2019

Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis

Jones-Todd, C. M., Caie, P., Illian, J. B., Stevenson, B. C., Savage, A., Harrison, D. J. & Bown, J. L., 15 Apr 2019, In : Statistics in Medicine. 38, 8, p. 1421-1441 21 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
70 Downloads (Pure)
2017

A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT

Bown, J. L., Shovman, M., Robertson, P., Boiko, A., Goltsov, A., Mullen, P. & Harrison, D. J., 2 May 2017, In : Oncotarget. 8, p. 29657-29667 11 p.

Research output: Contribution to journalArticle

Open Access
File
93 Downloads (Pure)

Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002

Goltsov, A., Tashkandi, G., Langdon, S. P., Harrison, D. J. & Bown, J. L., 15 Jan 2017, In : European Journal of Pharmaceutical Sciences. 97, p. 170–181 12 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
131 Downloads (Pure)

NRF2 regulates HER1 signaling pathway to modulate the sensitivity of ovarian cancer cells to lapatinib and erlotinib

Hamza Kankia, I., Khalil, H. S., Langdon, S. P., Moult, P. R., Bown, J. L. & Deeni, Y. Y., 19 Dec 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 19 p., 1864578.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
64 Downloads (Pure)
2016

A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells

Khalil, H. S., Langdon, S. P., Goltsov, A., Soininen, T., Harrison, D. J., Bown, J. & Deeni, Y. Y., 15 Nov 2016, In : Oncotarget. 7, p. 75874-75901 28 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
68 Downloads (Pure)

NRF2 regulates HER2 and HER3 signaling pathway to modulate sensitivity to targeted immunotherapies

Khalil, H. S., Langdon, S. P., Kankia, I. H., Bown, J. L. & Deeni, Y. Y., Jan 2016, In : Oxidative Medicine and Cellular Longevity. 2106, 22 p., 4148791.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
101 Downloads (Pure)
2015

Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells

Khalil, H. S., Goltsov, A., Langdon, S. P., Harrison, D. J., Bown, J. & Deeni, Y., 20 May 2015, In : Journal of Biotechnology. 202, p. 12-30 19 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
128 Downloads (Pure)

Understanding tissue morphology: model repurposing using the CoSMoS process

Sampson, A. T., Bown, J. L., Khalil, H. S. & Deeni, Y. Y., 1 Mar 2015, In : Natural Computing. 14, 1, p. 109–128 20 p.

Research output: Contribution to journalArticle

Open Access
File
80 Downloads (Pure)
2014

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations

Goltsov, A., Langdon, S. P., Goltsov, G., Harrison, D. J. & Bown, J. L., 5 Feb 2014, In : Frontiers in Oncology. 4, 13, 14 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
64 Downloads (Pure)
2013

Characterising the tumour morphological response to therapeutic intervention: an ex vivo model

Savage, A., Katz, E., Eberst, A., Falconer, R. E., Houston, A. N., Harrison, D. J. & Bown, J. L., Jan 2013, In : Disease Models & Mechanisms. 6, 1, p. 252-260 9 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
78 Downloads (Pure)

Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer

Hu, H., Goltsov, A., Bown, J. L., Sims, A. H., Langdon, S. P., Harrison, D. J. & Faratian, D., Jan 2013, In : Cellular Signalling. 25, 1, p. 26-32 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition

Idowu, M. A., Khalil, H. S., Bown, J. L. & Zhelev, N., 11 Dec 2013, In : BioDiscovery. 2013, 9, 32 p., 4.

Research output: Contribution to journalArticle

Open Access
File
83 Downloads (Pure)
2012

Engineering simulations for cancer systems biology

Bown, J. L., Andrews, P. S., Deeni, Y. Y., Goltsov, A., Idowu, M. A., Polac, F. A. C., Sampson, A. T., Shovman, M. & Stepney, S., Nov 2012, In : Current Drug Targets. 13, 12, p. 1560-1574 15 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
94 Downloads (Pure)

Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition

Goltsov, A., Faratian, D., Langdon, S. P., Mullen, P., Harrison, D. J. & Bown, J. L., Feb 2012, In : Cellular Signalling. 24, 2, p. 493-504 12 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
131 Downloads (Pure)

The meaning of graphs: scatterplots as a test-bed for theories of object-hood

Shovman, M., Scott-Brown, K. C., Szymkowiak, A. & Bown, J. L., 2012, In : Gestalt theory. 34, 3/4, p. 381-398 18 p.

Research output: Contribution to journalArticle

Open Access
2011

Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition

Goltsov, A., Faratian, D., Langdon, S. P., Bown, J. L., Goryanin, I. & Harrison, D. J., Feb 2011, In : Cellular Signalling. 23, 2, p. 407-416 10 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
90 Downloads (Pure)

Linking individual behaviour to community scale patterns in fungi

Falconer, R. E., Bown, J. L., White, N. A. & Crawford, J. W., Feb 2011, In : Fungal Ecology. 4, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
91 Downloads (Pure)

Modelling of Healthcare Associated Infections: a study on the dynamics of pathogen transmission by using an individual-based approach

Milazzoa, L., Bown, J. L., Eberst, A., Phillips, G. & Crawford, J. W., Nov 2011, In : Computer Methods and Programs in Biomedicine. 104, 2, p. 260-265

Research output: Contribution to journalArticle

17 Citations (Scopus)

Towards an exact reconstruction of a time-invariant model from time series data

Idowu, M. A. & Bown, J. L., 23 Nov 2011, In : Journal of Computer Science and Systems Biology. 4, 4, 15 p.

Research output: Contribution to journalArticle

Open Access
File
101 Downloads (Pure)
2010

Modelling fungal colonies and communities: challenges and opportunities

Falconer, R. E., Bown, J. L., McAdam, E. V., Perez-Reche, P., Sampson, A. T., van den Bulcke, J., White, N. A. & Perez-Reche, F. J., Dec 2010, In : IMA Fungus. 1, 2, p. 155-159 5 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
55 Downloads (Pure)
2009

A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells

Clyde, R. G., Craig, A. L., Breed, L. D., Bown, J. L., Forrester, L., Vojtesek, B., Smith, G., Hupp, T. R. & Crawford, J. W., 6 Dec 2009, In : Journal of the Royal Society Interface. 6, 41, p. 1167-1177 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2008

Modelling interactions in fungi

Falconer, R. E., Bown, J. L., White, N. A. & Crawford, J. W., Jun 2008, In : Journal of the Royal Society Interface. p. 603-615 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2007

Biomass recycling: a key to efficient foraging by fungal colonies

Falconer, R. E., Bown, J. L., White, N. A. & Crawford, J. W., Sep 2007, In : Oikos. 116, 9, p. 1558-1568 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Consequences of intraspecific variation for the structure and function of ecological communities: Part 1. Model development and predicted patterns of diversity

Bown, J. L., Pachepsky, E., Eberst, A., Bausenwein, U., Millard, P., Squire, G. R. & Crawford, J. W., Oct 2007, In : Ecological Modelling. 207, 2-4, p. 264-276 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Consequences of intraspecific variation for the structure and function of ecological communities Part 2: inking diversity and function

Pachepsky, E., Bown, J. L., Eberst, A., Bausenwein, U., Millard, P., Squire, G. R. & Crawford, J. W., Oct 2007, In : Ecological Modelling. 207, 2-4, p. 277-285 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2006

The role of modelling in identifying drug targets for diseases of the cell cycle

Clyde, R. G., Bown, J. L., Hupp, T. R., Zhelev, N. & Crawford, J. W., Oct 2006, In : Journal of the Royal Society Interface. 3, 10, p. 617-627 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2005

Biomass recycling and the origin of phenotype in fungal mycelia

Falconer, R. E., Bown, J. L., White, N. A. & Crawford, J. W., 22 Aug 2005, In : Proceedings of the Royal Society B: Biological Sciences. 272, 1573, p. 1727-1734 8 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2002

The effects of fungal inoculum arrangement (scale and context) on emergent community development in an agar model system

Sturrock, C. J., Ritz, K., Samson, W. B., Bown, J. L., Staines, H. J., Palfreyman, J. W., Crawford, J. W. & White, N. A., Jan 2002, In : FEMS Microbiology Ecology. 39, 10, p. 9-16 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
1999

Evidence for emergent behaviour in the community-scale dynamics of a fungal microcosm

Bown, J. L., Sturrock, C. J., Samson, W. B., Staines, H. J., Palfreyman, J. W., White, N. A., Ritz, K. & Crawford, J. W., 7 Oct 1999, In : Proceedings of the Royal Society B: Biological Sciences. 266, 1432, p. 1947-1952 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1998

Interspecific fungal interactions in spatially heterogeneous systems

White, N. A., Sturrock, C. J., Ritz, K., Samson, W. B., Bown, J. L., Staines, H. J., Palfreyman, J. W. & Crawford, J. W., Sep 1998, In : FEMS Microbiology Ecology. 27, 1, p. 21-32 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)