Research Output per year
Personal profile
Personal profile
Professional Qualifications
PGcert in Higher Education Teaching, Abertay University, 2018
Ph.D., Biotechnology (Cancer Biology), Bharathiar University, India, 2013
M.Sc., Biochemistry, Avinashilingam University, India, 2008
B.Sc., Biochemistry, Bharathiar University, India, 2006
Employment History
Post-doctoral research assistant, Abertay University, UK; Jun’ 17-present
Post-doctoral fellow, Bangor University, UK; Aug’ 14-Jan’16
Honorary Researcher, University of Liverpool, UK; Mar’14-Jun’14
Lecturer in Biotechnology, Bharathiar University, India; Jul’13-Dec’13
Personal Statement
Following a Bachelor's and a Master’s degree in Biochemistry, I carried out by doctoral studies in Bharathiar University, India in collaboration with National Dong Hwa University, Taiwan, studying molecular mechanisms involved in combination therapy of neferine and doxorubicin to induce autophagy and apoptosis in lung cancer cells. Then I have relocated to United Kingdom to pursue my postdoctoral fellowship in cancer. At the University of Liverpool, I studied the apoptosis mechanisms induced by maritoclax and Dinaciclib. Further in Bangor University, I have worked on the cellular uptake mechanism and anticancer efficiency of nitro-reductase coated gold magnetic nanoparticles for directed enzyme prodrug therapy (DEPT) in ovarian cancer cells. Currently, I am studying the role of NRF2 in ErbB targeted therapy in breast cancer cells.
Teaching
LSC 202 - Cell biology and Immunology
Funding
Senior Research Fellowship, Council of Scientific and Industrial Research, India, April, 2012
Junior Research Fellowship, Department of Science and Technology (DST), India and National Science Council (NSC), Taiwan, 2010
Travel awards (3 Nos.), Department of Science and Technology (DST), India, 2010-2013.
Esteem
Membership to Professional bodies
Member of British Association of Cancer Research
Member of European Association of Cancer Research
Member of Royal Society of Biology (MRSB), 2019
Fellow of Higher Education Academy (FHEA), 2018
Awards/Funding
Senior Research Fellow, Council of Scientific and Industrial Research, India, 2012
Junior Research Fellow, Department of Science and technology, India and National Science Council, Taiwan, 2010
Award for academic excellence, Avinashilingam University, India, 2008
Award for academic excellence, Bharathiar University, India, 2006
Invited talks
Resource person: “Role of NRF2 in drug resistance and cancer therapy” in the international conference on Biozone 2018 -Current trends in cancer research and therapeutics, Sacred Heart College, Thiruvalluvar University, India; 2018
Resource person: “NRF2 in chemo-resistance” in the lecture series on cancer at Sree Ramakrishna College of Arts and Science for Women, Bharathiar University, India; 2018
Resource person: “Targeting the shadows of redox modulating NRF2 to combat drug resistance in cancer” in the Technical seminar on cancer at Sree Narayana Guru College of Arts and Science, Bharathiar University, India; 2018
Keynote speaker: “Neferine as a double-edged sword towards doxorubicin resistance and cardiotoxicity” in the International conference of translational medicine at Institute of Biotechnology, National Dong Hwa University, Taiwan; 2011
Outreach
“A role for NRF-2 in the mechanism of action and effectiveness of dual tyrosine kinase inhibitor, lapatinib, in breast cancer cells” at 2018 NCRI Cancer Conference, taking place on at the Scottish Event Campus, Glasgow, UK; 2018
“Neferine as a chemosensitizing agent against doxorubicin resistant human lung adenocarcinoma cells” in World Biodiscovery Congress -2018, Dundee, UK; 2018
“Neferine, bisbenzyl-isoquinoline alkaloid from lotus (Nelumbo nucifera gaertn) induces mitochondria mediated apoptosis in liver cancer cells”, at Mitochondria in Biology and Medicine at Centre for cellular and molecular biology (CCMB), Hyderabad, India; 2011
“Optimizing cellular uptake of enzyme/gold coated magnetic nanoparticle conjugates for directed enzyme prodrug therapy (DEPT) for cancer” in LSRNW 1st annual drug discovery congress of Sêr Cymru – Life Sciences and Health NRN, Cardiff, UK; 2014
“Ginsenoside bioconversion by bacterial β-glucosidase” in MINDCRAFT at Karunya University, India; 2007
“Medicinal and nutritional importance of chicory”, at Nutraceuticals and the future of medical science” at Kongunadu Science College, India; 2007
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output
Berbamine ameliorates isoproterenol-induced myocardial infarction by inhibiting mitochondrial dysfunction and apoptosis in rats
Saranya, S., Baskaran, R., Poornima, P. & Vijaya Padma, V., Mar 2019, In : Journal of Cellular Biochemistry. 120, 3, p. 3101-3113 13 p.Research output: Contribution to journal › Article
3
Citations
(Scopus)
Biomaterial aided differentiation and maturation of induced pluripotent stem cells
Velmurugan, B. K., Priya, L. B., Paramasivan, P., Lee, L-J. & Baskaran, R., 30 Jun 2019, In : Journal of Cellular Physiology. 234, 6, p. 8443-8454 12 p.Research output: Contribution to journal › Review article
1
Citation
(Scopus)
Biopiracy versus one-world medicine – from colonial relicts to global collaborative concepts
Efferth, T., Banerjee, M., Abu-Darwish, M. S., Abdelfatah, S., Bockers, M., Bhakta-Guha, D., Bolzani, V., Daak, S., Demirezer, O. L., Dawood, M., Efferth, M., El-Seedi, H. R., Fischer, N., Greten, H. J., Hamdoun, S., Hong, C., Horneber, M., Kadioglu, O., Khalid, H. E., Khalid, S. A. & 21 others, , 28 Feb 2019, In : Phytomedicine. 53, p. 319-331 13 p.Research output: Contribution to journal › Article
Open Access
File
4
Citations
(Scopus)
81
Downloads
(Pure)
Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies
Paramasivan, P., Kankia, I. H., Langdon, S. P. & Deeni, Y. Y., 19 Sep 2019, In : Cancer Drug Resistance. 2, 3, p. 490-515 26 p.Research output: Contribution to journal › Article
Open Access
File
Neferine potentiates the antitumor effect of cisplatin in human lung adenocarcinoma cells via a mitochondria-mediated apoptosis pathway
Sivalingam, K. S., Paramasivan, P., Weng, C. F. & Viswanadha, V. P., 30 Sep 2017, In : Journal of Cellular Biochemistry. 118, 9, p. 2865-2876 12 p.Research output: Contribution to journal › Article
22
Citations
(Scopus)