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Sean Brown

Senior Lecturer

  • 160 Citations
  • 8 h-Index
20052019
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Personal profile

Personal profile

My research interests are focused on reproductive physiology – in particular, the regulation of sperm function. In collaboration with Professor Chris Barratt at the University of Dundee and NHS Tayside, I’m investigating ion channel (dys)function in human sperm. From a research perspective, I’m also interested in pedagogic research in online teaching.

I completed my PhD in Neuroscience at University College London.  Before joining Abertay University as a lecturer, I held postdoctoral research positions at University College London and the University of Dundee. My research experience includes investigating the electrophysiological and molecular analysis of GIRK channels, and the intracellular signalling pathways controlling ENaC expression.

I have previously acted as an external examiner for the Biotechnology degree at the Modern Science and Arts University in Cairo, Egypt.

Teaching

Undergraduate module tutor responsibilities;

  • LSC303 - Transfusion Science
  • LSC404 - Advanced Pathophysiology

Dr. Brown has a pedagogic research interest in the area of online teaching/learning and assessment.

Research interests

Dr. Brown is currently working in collaboration with Professor Chris Barratt at the University of Dundee and NHS Tayside working on the pathophysiology of human sperm.  His background is as an electrophysiologist (patch clamp) and has an interest in the molecular control of ion channel function and is currently involved in a studying examining ion channel (dys)function in human sperm.

Funding

Dr. Brown has been the recipient of Tenovus Scotland, Carnegie Scotland, Medical Research Council and Chief Scientist office grants.

Esteem

External examiner for Biotechnology degree at  Modern Science and Arts University, Cairo, Egypt (2012-14).

Reviewer for Human reproduction

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 3 Similar Profiles
Spermatozoa Medicine & Life Sciences
Progesterone Medicine & Life Sciences
Sperm Motility Medicine & Life Sciences
Fertilization Medicine & Life Sciences
Intracytoplasmic Sperm Injections Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Cations Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2005 2019

  • 160 Citations
  • 8 h-Index
  • 14 Article
  • 1 Abstract

The intracellular actions of trequinsin hydrochloride promotes human sperm motility

McBrinn, R., Brown, S. G., Fraser, J., Barratt, C. L. R., Martins da Silva, S., Gray, D. W. & Hope, A. G., 5 Jan 2019.

Research output: Contribution to conferenceAbstract

Sperm Motility
Spermatozoa
Acrosome Reaction
Intracytoplasmic Sperm Injections
Male Infertility
1 Citation (Scopus)
4 Downloads (Pure)

Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity

Brown, S. G., Miller, M. R., Lishko, P. V., Lester, D. H., Publicover, S. J., Barratt, C. L. R. & Martins da Silva, S., 1 Oct 2018, In : Human Reproduction. 33, 10, p. 1812-1816 5 p.

Research output: Contribution to journalArticle

Open Access
File
Spermatozoa
Cations
Exons
Exome
Mutation
2 Citations (Scopus)
8 Downloads (Pure)

Single-cell analysis of [Ca2+]i signalling in sub-fertile men: characteristics and relation to fertilization outcome

Kelly, M. C., Brown, S. G., Costello, S. M., Ramalingam, M., Drew, E., Publicover, S. J., Barratt, C. L. R. & Martins da Silva, S., 1 Jun 2018, In : Human Reproduction. 33, 6, p. 1023-1033 11 p., dey096.

Research output: Contribution to journalArticle

Open Access
File
Single-Cell Analysis
Fertilization
Progesterone
Intracytoplasmic Sperm Injections
Tissue Donors
3 Citations (Scopus)
18 Downloads (Pure)

Complex CatSper-dependent and independent [Ca2+]i signalling in human spermatozoa induced by follicular fluid

Brown, S. G., Costello, S., Kelly, M. C., Ramalingam, M., Drew, E., Publicover, S. J., Barratt, C. L. R. & Martins da Silva, S., 1 Oct 2017, In : Human Reproduction. 32, 10, p. 1995-2006 12 p.

Research output: Contribution to journalArticle

Open Access
File
Follicular Fluid
Spermatozoa
Progesterone
Tissue Donors
Research Ethics
2 Citations (Scopus)
23 Downloads (Pure)

Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem

Martins da Silva, S. J., Brown, S. G., Sutton, K., King, L. V., Ruso, H., Gray, D. W., Wyatt, P. G., Kelly, M. C., Barratt, C. L. R. & Hope, A. G., 1 May 2017, In : Human Reproduction. 32, 5, p. 974-984 11 p.

Research output: Contribution to journalArticle

Open Access
File
Male Infertility
Drug Discovery
Spermatozoa
Sperm-Ovum Interactions
Sperm Motility

Thesis

Role of second generation phosphodiesterase inhibitors on mammalian sperm mobility

Author: Madamidola, O., 2015

Supervisor: Brown, S. G. (Supervisor) & Adya, A. K. (Supervisor)

Student thesis: Doctoral Thesis

File