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1991 …2019
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Personal profile

Personal profile

I’m a Translational Researcher and a Senior Lecturer in Biotechnology and Biological Sciences. I’m also a Fellow of the Royal Society of Biology.

Previously, I held academic and research positions at the Bayero University, Nigeria and at the Biomedical Research Institute at the University of Dundee. 

My research in molecular systems pharmacology is essentially about understanding and overcoming drug and chemical resistance including anticancer, antimicrobial, antimalarial, and insecticide/pesticide resistances. I use molecular and biochemical techniques to assess the impact of drugs and environmental toxicants on cellular defence, disease and survival.

My current research interests include investigating malaria control through targeting mosquito defence systems and investigating the role of the antioxidant response, the DNA damage response and the hypoxia response pathways in the etiology and treatment of cancer.  I’m currently collaborating with the School of Tropical Medicine in Liverpool, the University of Edinburgh, the University of St. Andrews, and the Biomedical Research Institute, University of Dundee. 

I am a member of a multidisciplinary research team based at Abertay which uses experimental and modelling approaches to examine complex problems which impact on everyday life.  

I speak Hausa, English, and some Arabic and French.

Professional Qualifications:

1981    BSc (Honours, Cum Laude) Biological Sciences, Savannah State University, Savannah, USA

1989    MSc Biology (Microbiology), Bayero University, Kano, Nigeria

1998    PhD Molecular Biology (Pharmacology/Toxicology), University of Dundee,  Dundee, Scotland, UK

Professional Employment History:

1983 – 1985    Education Officer, Kano State, Kano, Nigeria

1985 – 1986    Higher Education Officer, Kano State, Kano, Nigeria

1986 – 1989    Inspector of Education, Kano State, Kano, Nigeria

1989 – 1991    Assistant Lecturer, Biological Sciences, Bayero University, Kano, Nigeria

1991 – 1998    Lecturer, Biological Sciences, Bayero University, Kano, Nigeria

1998 – 2005    Postdoctoral Research Associate, BRC, University of Dundee, Scotland, UK

2005 – 2007    Principal Investigator, Biomedical Research Institute, University of Dundee, Scotland, UK

2007 - 2014     Lecturer in Biotechnology & Biological Sciences, University of Abertay Dundee, Dundee, Scotland, UK

2014 - Now      Senior Lecturer in Biotechnology & Biological Sciences, Abertay University, Dundee, Scotland, UK

Teaching

I teach undergraduate and postgraduate courses in Biotechnology, Bioinformatics, Biomedical Sciences and Forensic Science. Specific subject areas include: Analytical Biotechnology, Biotechniques, Molecular and Cellular Biology, Structural and Functional Genomics/Proteomics, Molecular Carcinogenesis, Pharmacogenetic/Pharmacogenomics and Perspectives in Biotechnology.

These aspects are covered in the past and current modules I teach:

Past:

BI0704A Professional Skills,
BI0805A Techniques & Skills 2A,
BI0903A Molecular & Cell Biology: Molecular Genetics,
BI0911A Applied Molecular & Cell Biology,
BI1003A Molecular & Cell Biology: Genome Structure & Function 4,
BI1004A Contemporary & Industrial Biotechnology & Biomedical Science,
BI1005A Techniques & Skills,
BI1006A Honours Project,
BI1008A BMS Honours Project,
BI1009A Project Skills,
BI1101 Perspectives of Biotechnology,
BI1102A Analytical Biotechnology,
BI1104A Biotechnology Case Review,
BI1106A Placement Research Project (MSc Biotechnology),
BI1114A MSc Bioinformatics Project & Dissertation,
BI1115A Molecular Techniques,
BI1116A Structural & Functional Genomics,
BI1119A Introduction to
BI1121A Research Project (MSc Renewable Bio-Energy), Bioinformatics Techniques,
BI1123A Molecular & Cellular Biology 5:
HS0916 Essential Pharmacology for Biomedical Sciences, Genome Structure & Function,
HS1003A Molecular Genetics of Human Disease,
HS1006A Clinical Pharmacology & Toxicology,
HS1104A Human Disease Molecular Genetics,
HS1106A Medical Pharmacology & Toxicology

Current:

LSC101 Biology 1: Biology Principles and Practice

LSC252 Cell Biology & Physiology

LSC253 Medical Microbiology

LSC401 Project Research Methods

ELE008 Communicating Science

LSC201 Molecular Biology and Genetics

LSC304 Perspectives in the Life Sciences Industry

LSC306 Test-tube to tablet

LSC401 Literature Review

LSC402 Honours Project

Research interests

Drug Discovery and Development (Cancer & Tropical Diseases, including Computational/Mathematical Modelling), Protein Engineering, Applied Pharmaceutical and Environmental Biotechnology, Renewable Bio-Energy.

I am a member of SIMBIOS a multidisciplinary research team using systems approaches to complex ecological, biological & environmental problems. SIMBIOS focuses on the emergence of (i) soil ecosystem functioning from the microscopic complexity of soils and (ii) tumours in tissue from cell.

I am interested in Translational Research were current focus is on integrated approach of combining experimental analyses and bioinformatics (mathematical & computer modelling). I apply molecular and biochemical techniques (quantitative, integrative and systems biology) to assess the impact of xenobiotics (drugs) and other environmental toxicants on cellular or organismal intrinsic and adaptive responses in defence, disease and survival. Specific current projects themes include:

1. Investigate the biological roles of the DNA damage response and the antioxidant response pathways in the aetiology and treatment of cancer

2. Investigate Malaria Vector Control: Ecological Studies and Targeting the mosquito (Anopheles gambiae; Anopheles funestus) defence enzymes system to overcome pesticide resistance.

3. Investigate Sorghum and its utilisation as alternative renewable energy source

These focused research themes will encompass a number of sub-themes aimed at:

  • Gene Regulation, Expression Profiling and Disease Biomarker Identification
  • Screening and Validation of Target Small Molecule to Treat Diseases(s)
  • Cell and Organismal Model for Pharmacology and Toxicology
  • Protein-Enzyme/Metabolic Engineering
  • System Network and  Biology

Current Collaborations:

Simon Langdon & David Harrison, Breakthrough Research Unit, Division of Pathology, College of Medicine & Veterinary Medicine, University of Edinburgh.

Roland Wolf & Gillian Smith, Biomedical Research Institute, Ninewells Hospital & Medical School, University of Dundee.

Mark J Paine, School of Tropical Medicine, University of Liverpool http://www.liv.ac.uk/lstm/groups/vector.htm

Current Funding:

Carnegie Trust http://www.carnegie-trust.org/

Funding

In addition to internal UAD complementation, a number of funding mechanisms support my research :

2008 – 2010        £2,470; Malaria Vector Control: Cloning and Expression of Anopheles gambiae Glutathione Biosynthetic Defense Enzyme System, Carnegie Trust

2008 – 2010        £160,000; Cancer Project (Lead by Professor John Palfreyman), Anonymous Trust

2010 – 2012        £200,000; Cancer Project (Lead by Professor John Palfreyman), Anonymous Trust

2010 – 2013        £150,000 (with Professor GM Walker); Molecular and Biochemical Assessment of the effects of Environmental    Agroallied- and Petro-chemicals on the occurrence and distribution of Insecticides resistant Mosquitoes in Nigeria. PhD studentship, PTDF Nigeria

2011 – 2013        £150,000 (with Professor GM Walker); Bioethanol Production Potential from Indigenous Sweet Sorghum Crop for Utilization as Renewable Automotive Fuel in Nigeria; PhD studentship, PTDF Nigeria.

2012 – 2014        £120,000 (with Professor John Palfreyman); Regulation of Insecticide Defense and Resistance Gene(s) in Anopheles sp; PhD studentship, TETFunds Nigeria.

2012 – 2014        £120,000 (with Dr Andrew Spiers); Molecular Characterization of Insecticide Defense Genes of Field Captured Mosquitoes in Nigeria; PhD studentship, TETFunds Nigeria.

Esteem

Professional Activities:

2006 – Now     Referee/Reviewer

Archives of Biochemistry and Biophysics, Insects Molecular Biology, Fitoterapia, Pharmaceutical Biology, International J. Environmental & Analytical Chemistry, Open Drug Metabolism J., Electronic J. Biotechnology, Electronic J. Biotechnology, Bioenergy Technology, J. Biochemical & Molecular Toxicology, Biochemical J. and Carcinogenesis.

2008 – Now     Editorial Board Membership

The Open Drug Metabolism Journal http://www.bentham.org/open/todmj/index.htm

Philosophic Nature Journal

Bayero Journal of Pure and Applied Sciences (BAJOPAS) http://ajol.info/index.php/bajopas.

2006 – Now     Professional Body Membership

Biochemical Society, International Society for the Study of Xenobiotics (ISSX), European Association for Cancer Research, European Biotechnology Thematic Network, Nigerian Society for Microbiology.

2009 – 2010    Distinction/Recognition

                        Resource Person to the National Institute for Health, Bethesda, USA

2009 – Now     Collaborators

Dr Simon Langdon, Edinburgh Cancer Research Centre, Western General Hospital, University of Edinburgh.

Dr Mark J Paine, School of Tropical Medicine, University of Liverpool http://www.liv.ac.uk/lstm/groups/vector.htm

Professor C Roland Wolf and Dr Gillian Smith, Biomedical Research Institute, Ninewells Hospital & Medical School, University of Dundee.

Dr M D Mukhtar, Dr A Yayo and Dr M Y Gwarzo, Bayero University, Kano Nigeria. http://www.buk.edu.ng/

2006 – Now     Conferences

British Society for Investigative Dermatology Meeting,10-12 April 2006, University of Manchester, UK.

8th Annual BioDundee International Conference, 22-23 May 2008, Dundee

European Biotechnology Thematic Network Meeting, 4-7 September, 2008, Bratislava, Slovak Republic

International Conference, ‘Biomarkers in Personalised Medicine’, 23 April 2009, University of Edinburgh, Edinburgh.

 ‘Biodiversity Themes’. Invited Speaker; “Medicinal Plants Diversity and Drug Discovery”, 2 May, 2009, Dundee Science Centre (Sensation), Dundee.

Workshop, ‘An Introduction to Commercial Skills for Life Scientists', 6-7 May, 2009 (BBRC funded) University of Dundee, Dundee.

 The RESEARCH CONTINUUM in Natural Products Drug Discovery, Invited Speaker, “Bioinformatics: An Integrated Approach to Drug Discovery”, 12-14 May 2009, (organised by NIH/NIAID of USA and NIPRD of Nigeria), Abuja, Nigeria.

Workshop on Renewable Energy (organised by Dundee Renewables with support from Tayside/Dundee City Council and The Scottish Enterprises), May 10th 2010, Dundee

Energy Industries Overview: Oil and Gas and Renewable Energy, 12 - 14 April 2011, King's College Conference Centre, University of Aberdeen, Aberdeen.

European Biotechnology Congress, Invited speaker, International Advisory Committee Member & Editorial Review Member, 28 September-1 October, 2011, Istanbul, Turkey.

35th Annual Conference& Annual General Meeting of the Nigerian Society for Microbiology NSM-BUK 2011. Invited Lead Speaker, Microbes in Human Development: Microbiology the Steering to Drive Biotechnological Development, 9-13 October, 2011, Bayero University, Kano, Nigeria.

Knowledge and Exchange

In addition to internal UAD complementation, a number of funding mechanisms support my research :

2008 – 2010        £2,470; Malaria Vector Control: Cloning and Expression of Anopheles gambiae Glutathione Biosynthetic Defence Enzyme System, Carnegie Trust

2008 – 2010        £160,000; Cancer Project (Lead by Professor John Palfreyman), Anonymous Trust

2010 – 2012        £200,000; Cancer Project (Lead by Professor John Palfreyman), Anonymous Trust

2010 – 2013        £150,000 (with Professor GM Walker); Molecular and Biochemical Assessment of the effects of Environmental    Agroallied- and Petro-chemicals on the occurrence and distribution of Insecticides resistant Mosquitoes in Nigeria. PhD studentship, PTDF Nigeria

2011 – 2013        £150,000 (with Professor GM Walker); Bioethanol Production Potential from Indigenous Sweet Sorghum Crop for Utilization as Renewable Automotive Fuel in Nigeria; PhD studentship, PTDF Nigeria.

2012 – 2014        £120,000 (with Professor John Palfreyman); Regulation of Insecticide Defense and Resistance Gene(s) in Anopheles sp; PhD studentship, TETFunds Nigeria.

2012 – 2014        £120,000 (with Dr Andrew Spiers); Molecular Characterization of Insecticide Defense Genes of Field Captured Mosquitoes in Nigeria; PhD studentship, TETFunds Nigeria.

Knowledge and Exchange

2011 – 2013     £150,000 (Co-Investigator with Dr Andrew Spiers); Biofilm and Bacterial Bioremediation of Environmental Petrochemical; PhD studentship – Ibrahim Mohammad, PTDF Nigeria

Knowledge and Exchange

2012 – 2015     £150,000 (Principal Investigator with Dr Andrew Spiers); investigating the role of glutathione and glutathione biosynthetic enzymes in the adaptation of Anopheles gambiae to insecticides; PhD studentship – Habibu Abdu, TET Fund Nigeria.

Knowledge and Exchange

2012 – 2015     £150,000 (Principal Investigator with Dr Phil Collier); Regulatory mechanisms in the control of CYP6M2; PhD studentship – Balarabe M Rabiu, TET Fund Nigeria.

Knowledge and Exchange

2010 – 2013     £150,000 (Principal Investigator with Professor GM Walker); Molecular and Biochemical Assessment of the effects of Environmental Agroallied- and Petro-chemicals on the occurrence and distribution of Insecticides resistant Mosquitoes in Nigeria. PhD studentship – Abdullahi Imam, PTDF Nigeria

Funding

2010 – 2012     £200,000; Cancer Project (Named Researcher, Led by Professor John Palfreyman), Anonymous Trust

Funding

2008 – 2010     £160,000; Cancer Project (Named Researcher, Led by Professor John Palfreyman), Anonymous Trust

Funding

2008 – 2010     £2,470; Malaria Vector Control: Cloning and Expression of Anopheles gambiae Glutathione Biosynthetic Defense Enzyme System, Principal Investigator Carnegie Trust

Knowledge and Exchange

2012 – 2015     £150,000 (Principal Investigator with Dr Andrew Spiers); investigating the role of glutathione and glutathione biosynthetic enzymes in the adaptation of Anopheles gambiae to insecticides; PhD studentship – Habibu Abdu, TET Fund Nigeria.

Knowledge and Exchange

2014                £6000.00 Academic Research Visitor for Molecular characterisation of clinical isolates of Plasmodium falciparum for antimalarial drug resistance (Visitor – Ruqayya Muhammad TET Fund Nigeria).

Knowledge and Exchange

2014                £8000.00 Academic Research Visitor for Molecular characterisation of clinical isolates for antimicrobial drug resistance (Visitor - Ibrahim Zurmi TET Fund Nigeria with Dr Andrew Spiers).

Funding

2012 – 2013     £250,000; Cancer Project (Named Researcher, Led by Professor James Bown), Northwood Trust

Funding

2013 – 2014     £200,000; Cancer Project (Named Researcher, Led by Professor James Bown), Northwood Trust

Knowledge and Exchange

2012 – 2017     £150,000 (Principal Investigator with Professor James Bown); investigating natural/synthetic compounds for antioxidant and anticancer activities; PhD studentship – Ibrahim Hamza Kankia, TET Fund Nigeria.

Knowledge and Exchange

2012 – 2017     £150,000 (Principal Investigator with Dr Andrew Spiers); Biofilm and Bacterial Surfactants Prospecting for Bioremediation and Biotechnology; PhD studentship – Kamaluddeen Kabir, TET Fund Nigeria.

Funding

2014 – 2015     £188,000; Cancer Project (Named Researcher, Led by Professor James Bown), Northwood Trust

Knowledge and Exchange

2015                £3000.00 Academic Research Visitor for Molecular characterisation of isolates for heavy metal resistance (Visitor – Ali Haroun TET Fund Nigeria with Dr Andrew Spiers).

Funding

2015– 2016      £188,000; Cancer Project (Named Researcher, Led by Professor James Bown), Northwood Trust

Funding

2016– 2017      £188,000; Cancer Project (Named Researcher, Led by Professor James Bown & Professor Nikolai Zhelev), Northwood Trust

Knowledge and Exchange

2016 – 2019     £150,000 (Co-Investigator with Professor Joseph Akunna and Professor Graeme Walker); Biofilm and Bacterial Bioremediation of Environmental Petrochemical; PhD studentship – Benson Jelani Ftepti, PTDF Nigeria

Knowledge and Exchange

2017 – 2020     £150,000 (Co-Investigator with Dr Scott Cameron and Dr Andrew Spiers); Biofilm and Bacterial Bioremediation of Environmental Petrochemical; PhD studentship – Raji Bamanga, PTDF Nigeria

Knowledge and Exchange

2017                £7,500.00 Academic Research Visitor for Biochemical and Molecular Characterisation of Rhizobia Cow Pea Nodular Isolates (Visitor – Halima M Rabiu, TET Fund Nigeria.

Knowledge and Exchange

2017 – now      £5000.00 In vitro evaluation of the cytoprotective, anticancer, anti-inflammatory and/or wound healing medicinal values of Kaerling skin balm and oils. Innovate UK.

Knowledge and Exchange

2017 – now      £6,500.00 Academic Research Visitor for Virulence Typing and Molecular Characterization of Extended-Spectrum Beta-Lactamases (ESBLs) in E. coli Pathotypes from Clinical Samples (Visitor – Mahmud Yerima, TET Fund Nigeria.

Knowledge and Exchange

2018 – 2021     £150,000 (Co-Investigator with Professor Nikolai Zhelev); Curbing Environmental Pollution of Water Hyacinth by using it in drug discovery; PhD studentship – Wafiya Jibrin, PTDF Nigeria

Funding

2018 – now      £2,400.00 Melville Trust Summer Studentship awards (Student – Matthew Elcombe) Bioinformatics analyses of the Nrf2-antioxidant signalling pathway in response to HER-targeted therapy for pre-clinical breast cancer models. The Melville Trust.

Knowledge and Exchange

2012 – 2015     £150,000 (Principal Investigator with Dr Phil Collier); Studies on the Occurrence of Antibiotic-Resistant Bacterial Strains from Agriculture-Associated Waters and their Proteomic and Genomic Characterizations; PhD studentship – Mukhtar Althiyabi, Kingdom of Saudi Arabia

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Cytochrome P-450 Enzyme System Medicine & Life Sciences
ethanol production Agriculture & Biology
NF-E2-Related Factor 2 Medicine & Life Sciences
Ovarian Neoplasms Medicine & Life Sciences
Cells Chemical Compounds
ethanol Agriculture & Biology
Loranthaceae Medicine & Life Sciences
Cytochrome P-450 CYP2D6 Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1991 2019

Sweet sorghum: agronomic practice for food, animal feed and fuel production in Sub-Saharan Africa

Nasidi, M., Agu, R., Walker, G. M. & Deeni, Y. Y., 30 Apr 2019, Sweet sorghum: characteristics, cultivation and uses . Rogers, L. & Willis, M. (eds.). Nova Science Publishers, Inc., (Agriculture Issues and Policies).

Research output: Chapter in Book/Report/Conference proceedingChapter

sweet sorghum
fuel production
Sub-Saharan Africa
plant cultural practices
juices

Differential expression of insecticide resistance genes in Anopheles gambiae from Northern Nigeria

Abdu, H. U., Spiers, A. J., Hapca, S., Dauda, M. M. & Deeni, Y. Y., 30 Aug 2018, In : Journal of Biotechnology. 280, Suppl., p. S22-S22 1 p.

Research output: Contribution to journalMeeting Abstract

1 Citation (Scopus)
2 Downloads (Pure)

Uncovering behavioural diversity amongst high-strength Pseudomonas spp. surfactants at the limit of liquid surface tension reduction

Kabir, K., Deeni, Y. Y., Hapca, S. M., Moore, L. & Spiers, A. J., 1 Feb 2018, In : FEMS Microbiology Letters. 365, 4, 7 p., fny008.

Research output: Contribution to journalArticle

Open Access
File
Surface-Active Agents
Surface tension
Liquids
Genes
Lipopeptides
3 Citations (Scopus)
9 Downloads (Pure)

Biofilm formation and cellulose expression by Bordetella avium 197N, the causative agent of bordetellosis in birds and an opportunistic respiratory pathogen in humans

McLaughlin, K., Folorunso, A. O., Deeni, Y. Y., Foster, D., Gorbatiuk, O., Hapca, S. M., Immoor, C., Koza, A., Mohammed, I., Moshynets, O., Rogalsky, S., Zawadzki, K. & Spiers, A. J., Jun 2017, In : Research in Microbiology. 168, 5, p. 419–430 12 p.

Research output: Contribution to journalArticle

Open Access
File
Bordetella avium
Operon
Biofilms
Cellulose
Birds

High-activity surfactants expressed by Pseudomonas spp. show significant behavioural differences

Kabir, K., Deeni, Y., Mohammed, I. & Spiers, A., 2017, p. 41-41. 1 p.

Research output: Contribution to conferenceAbstract

Open Access

Thesis

Bioprospecting surfactants produced by Pseudomonas spp. isolated from soil for potential application in biotechnology

Author: Kabir, K., 18 Aug 2017

Supervisor: Spiers, A. J. (Supervisor) & Deeni, Y. Y. (Supervisor)

Student thesis: Doctoral Thesis

Design and development of novel tools for the screening and identification of inhibitors of HER receptor family and NFR2 for ovarian cancer therapy

Author: Hamza Kankia, I., 31 Oct 2017

Supervisor: Moult, P. R. (Supervisor) & Deeni, Y. Y. (Supervisor)

Student thesis: Doctoral Thesis

File

Regulatory mechanisms involved in the control of CYP6M2 gene in insecticide resistant Anopheles gambiae (Diptera: culicidae)

Author: Mohammed Rabiu, B., Dec 2014

Supervisor: Deeni, Y. Y. (Supervisor)

Student thesis: Doctoral Thesis

File

Role of physico-chemical environmental factors in the emergence and development of insecticides resistant mosquito in Nigeria

Author: Imam, A., Aug 2013

Supervisor: Deeni, Y. (Supervisor) & M. Walker, G. (Supervisor)

Student thesis: Doctoral Thesis

File