A tumor microenvironment-responsive biodegradable mesoporous nanosystem for anti-inflammation and cancer theranostics

Jianrong Wu, Shiwei Niu, David H Bremner, Wei Nie, Zi Fu, Dejian Li*, Li-Min Zhu*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    Abstract

    A nanoplatform that integrates diagnostic and therapeutic functions with intrinsic tumor microenvironment-responsive biodegradability is highly desired. Herein, a biodegradable nanotheranostic agent based on hollow mesoporous organosilica nanoparticles (HMONs), followed by encapsulating of heat shock protein 90 (Hsp 90) inhibitor is described. Then, the pore-engineering including gating with bovine serum albumin-iridium oxide nanoparticles (BSA-IrO2 ) and conjugation of polyethylene glycol (PEG) is conducted to yield 17AAG@HMONs-BSA-IrO2 -PEG (AHBIP) nanotheranostics for multimode computed tomography (CT)/photoacoustic (PA) imaging-guided photodynamic therapy (PDT) and low-temperature photothermal therapy (PTT). Such nanoplatforms show extraordinary photothermal conversion efficiency, high cargo loading (35.4% for 17AAG), and stimuli-responsive release of 17AAG for inhibition of Hsp90, which induces cell apoptosis at low-temperatures (≈41 °C). Also, the IrO2 simultaneously endows the nanotheranostics with catalytic activity in triggering the decomposition of H2O2 into O2 and thus reducing the tumor hypoxia, as well as protecting normal tissues against H2O2 -induced inflammation. AHBIP shows good photocatalysis activity for PDT as a result of the generation of superoxide anion by laser irradiation. The resulting AHBIP-mediated synergistic PTT/PDT offers an outstanding therapeutic outcome both in vitro and in vivo. Overall, the incorporation of the BSA-IrO2 and biodegradable HMONs into one nanoplatform has great potential for clinical applications.

    Original languageEnglish
    Article number1901307
    Pages (from-to)e1901307
    Number of pages12
    JournalAdvanced healthcare materials
    Early online date9 Dec 2019
    DOIs
    Publication statusE-pub ahead of print - 9 Dec 2019

    Fingerprint

    tanespimycin
    Nanosystems
    Tumor Microenvironment
    Nanoparticles
    Photodynamic therapy
    Tumors
    Photochemotherapy
    Inflammation
    Polyethylene glycols
    Neoplasms
    HSP90 Heat-Shock Proteins
    Temperature
    Photoacoustic effect
    Photocatalysis
    Biodegradability
    Iridium
    Cell death
    Laser beam effects
    Therapeutics
    Bovine Serum Albumin

    Cite this

    Wu, Jianrong ; Niu, Shiwei ; Bremner, David H ; Nie, Wei ; Fu, Zi ; Li, Dejian ; Zhu, Li-Min. / A tumor microenvironment-responsive biodegradable mesoporous nanosystem for anti-inflammation and cancer theranostics. In: Advanced healthcare materials. 2019 ; pp. e1901307.
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    abstract = "A nanoplatform that integrates diagnostic and therapeutic functions with intrinsic tumor microenvironment-responsive biodegradability is highly desired. Herein, a biodegradable nanotheranostic agent based on hollow mesoporous organosilica nanoparticles (HMONs), followed by encapsulating of heat shock protein 90 (Hsp 90) inhibitor is described. Then, the pore-engineering including gating with bovine serum albumin-iridium oxide nanoparticles (BSA-IrO2 ) and conjugation of polyethylene glycol (PEG) is conducted to yield 17AAG@HMONs-BSA-IrO2 -PEG (AHBIP) nanotheranostics for multimode computed tomography (CT)/photoacoustic (PA) imaging-guided photodynamic therapy (PDT) and low-temperature photothermal therapy (PTT). Such nanoplatforms show extraordinary photothermal conversion efficiency, high cargo loading (35.4{\%} for 17AAG), and stimuli-responsive release of 17AAG for inhibition of Hsp90, which induces cell apoptosis at low-temperatures (≈41 °C). Also, the IrO2 simultaneously endows the nanotheranostics with catalytic activity in triggering the decomposition of H2O2 into O2 and thus reducing the tumor hypoxia, as well as protecting normal tissues against H2O2 -induced inflammation. AHBIP shows good photocatalysis activity for PDT as a result of the generation of superoxide anion by laser irradiation. The resulting AHBIP-mediated synergistic PTT/PDT offers an outstanding therapeutic outcome both in vitro and in vivo. Overall, the incorporation of the BSA-IrO2 and biodegradable HMONs into one nanoplatform has great potential for clinical applications.",
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    A tumor microenvironment-responsive biodegradable mesoporous nanosystem for anti-inflammation and cancer theranostics. / Wu, Jianrong; Niu, Shiwei; Bremner, David H; Nie, Wei; Fu, Zi; Li, Dejian; Zhu, Li-Min.

    In: Advanced healthcare materials, 09.12.2019, p. e1901307.

    Research output: Contribution to journalArticle

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    AU - Fu, Zi

    AU - Li, Dejian

    AU - Zhu, Li-Min

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