Advocating the need of a systems biology approach for personalised prognosis and treatment of B-CLL patients

Hemanth Tummala, Alexey Goltsov, Hilal S. Khalil, Anne Sproul, Fiona Scott, Vanio Mitev, Nikolai Zhelev

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Abstract

The clinical course of B-CLL is heterogeneous. This heterogeneity leads to a clinical dilemma: can we identify those patients who will benefit from early treatment and predict the survival? In recent years, mathematical modelling has contributed significantly in understanding the complexity of diseases. In order to build a mathematical model for determining prognosis of B-CLL one has to identify, characterise and quantify key molecules involved in the disease. Here we discuss the need and role of mathematical modelling in predicting B-CLL disease pathogenesis and suggest a new systems biology approach for a personalised therapy of B-CLL patients.
Original languageEnglish
Number of pages15
JournalBioDiscovery
Volume6
Issue number4
DOIs
Publication statusPublished - 30 Dec 2012

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