Approaches towards the detection of sepsis: a review

Alice Jane Heeroma, Jane Toffrey, Christopher David Gwenin

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Our understanding of sepsis and its mechanisms have never been more important than they are today. In recent years we have seen sepsis manifest from bacterial infection to a broader range of pathogens, each with its unique responses from the body. This increased interest has only been further intensified by the Covid-19 pandemic and the renewed global attention towards viral-based infections and their interactions with sepsis. From Systemic inflammatory response syndrome (SIRS) to sequential organ failure assessment score (SOFA), studies have shown that early diagnosis is key, as well as finding the root of the infection to prevent further damage caused to the patient. Prompt treatment has contributed to the overall improvement of sepsis outcomes. This review summarizes the development of the cause, diagnosis, and treatments available to date.
Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalInternational Journal of Biomedical and Clinical Analysis
Issue number1
Early online date26 Feb 2021
Publication statusPublished - 26 Feb 2021
Externally publishedYes


  • Sepsis
  • Covid-19
  • Viral-based infections
  • Early diagnosis
  • Bacterial infection


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