Arabino mycolates from synthetic mycolic acids

Mohsin O. Mohammed; Mark S. Baird; Juma'a R. Al Dulayymi; Alison Jones; Christopher D. Gwenin

doi:10.1016/j.tet.2016.03.083

Arabino mycolates from synthetic mycolic acids

Mohsin O. Mohammed
, Mark S. Baird^*
, Juma'a R. Al Dulayymi
, Alison Jones
, Christopher D. Gwenin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The synthesis of single mono-arabino mycolates, important lipid antigens from mycobacteria is described, using structurally defined synthetic mycolic acids. Preliminary assays indicate that these are differentially antigenic to antibodies in the serum of people with active tuberculosis.

Original language	English
Pages (from-to)	2849-2857
Number of pages	9
Journal	Tetrahedron
Volume	72
Issue number	22
Early online date	31 Mar 2016
DOIs	https://doi.org/10.1016/j.tet.2016.03.083
Publication status	Published - 2 Jun 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Mycobacteria
Tuberculosis
Arabino mycolates
Antigens

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10.1016/j.tet.2016.03.083

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title = "Arabino mycolates from synthetic mycolic acids",

abstract = "The synthesis of single mono-arabino mycolates, important lipid antigens from mycobacteria is described, using structurally defined synthetic mycolic acids. Preliminary assays indicate that these are differentially antigenic to antibodies in the serum of people with active tuberculosis.",

author = "Mohammed, \{Mohsin O.\} and Baird, \{Mark S.\} and \{Al Dulayymi\}, \{Juma'a R.\} and Alison Jones and Gwenin, \{Christopher D.\}",

note = "Funding Information: M.M. wishes to thank the Ministry of Higher Education \& Scientific Research –Kurdistan Region, Iraq for the award of a grant. We thank the EPSRC UK National Mass Spectrometry Facility at Swansea University for carrying out accurate mass measurements. We thank Dr. A Ramsay and the Special Programme for Research and Training in Tropical Diseases at the World Health Organization for access to materials from the TDR TB Specimen Bank. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",

year = "2016",

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doi = "10.1016/j.tet.2016.03.083",

language = "English",

volume = "72",

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journal = "Tetrahedron",

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T1 - Arabino mycolates from synthetic mycolic acids

AU - Mohammed, Mohsin O.

AU - Baird, Mark S.

AU - Al Dulayymi, Juma'a R.

AU - Jones, Alison

AU - Gwenin, Christopher D.

N1 - Funding Information: M.M. wishes to thank the Ministry of Higher Education & Scientific Research –Kurdistan Region, Iraq for the award of a grant. We thank the EPSRC UK National Mass Spectrometry Facility at Swansea University for carrying out accurate mass measurements. We thank Dr. A Ramsay and the Special Programme for Research and Training in Tropical Diseases at the World Health Organization for access to materials from the TDR TB Specimen Bank. Publisher Copyright: © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/6/2

Y1 - 2016/6/2

N2 - The synthesis of single mono-arabino mycolates, important lipid antigens from mycobacteria is described, using structurally defined synthetic mycolic acids. Preliminary assays indicate that these are differentially antigenic to antibodies in the serum of people with active tuberculosis.

AB - The synthesis of single mono-arabino mycolates, important lipid antigens from mycobacteria is described, using structurally defined synthetic mycolic acids. Preliminary assays indicate that these are differentially antigenic to antibodies in the serum of people with active tuberculosis.

U2 - 10.1016/j.tet.2016.03.083

DO - 10.1016/j.tet.2016.03.083

M3 - Article

AN - SCOPUS:84964584647

SN - 0040-4020

VL - 72

SP - 2849

EP - 2857

JO - Tetrahedron

JF - Tetrahedron

IS - 22

ER -

Arabino mycolates from synthetic mycolic acids

Abstract

UN SDGs

Keywords

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