Bifurcation in blood oscillatory rhythms for patients with ischemic stroke: a small scale clinical trial using laser Doppler flowmetry and computational modelling of vasomotion

Alexey Goltsov, Anastasia Anisimova, Maria Zakharkina, Alexander I. Krupatkin, Viktor V. Sidorov, Sergei G. Sokolovski, Edik Rafailov

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    Abstract

    We describe application of spectral analysis of laser Doppler flowmetry (LDF) signals to investigation of cerebrovascular haemodynamics in patients with post-acute ischemic stroke (AIS) and cerebrovascular insufficiency. LDF was performed from 3 to 7 days after the onset of AIS on forehead in the right and left supraorbital regions in patients. Analysis of LDF signals showed that perfusion in the microvasculature in AIS patients was lower than that in patients with cerebrovascular insufficiency. As a result of wavelet analysis of the LDF signals we obtained activation of the vasomotion in the frequency range of myogenic oscillation of 0.1 Hz and predominantly nutritive regime microcirculation after systemic thrombolytic therapy of the AIS patients. In case of significant stroke size, myogenic activity and nutritive pattern microhaemodynamics were reduced, in some cases non-nutritive pattern and/or venular stasis was revealed. Wavelet analysis of the LDF signals also showed asymmetry in wavelet spectra of the LDF signals obtained in stroke-affected and unaffected hemispheres in the AIS patients. A mechanism underlying the observed asymmetry was analysed by computational modelling of vasomotion developed in (Arciero & Secomb, 2012). We applied this model to describe relaxation oscillation of arteriole diameter which is forced by myogenic oscillation induced by synchronous calcium oscillation in vascular smooth muscle cells. Calculation showed that vasomotion frequency spectrum at the low-frequency range (0.01 Hz) is reciprocally modulated by myogenic oscillation (0.1 Hz) that correlates with experimental observation of inter-hemispheric variation in the LDF spectrum.
    Original languageEnglish
    Article number160
    Number of pages11
    JournalFrontiers in Physiology
    Volume8
    DOIs
    Publication statusPublished - 23 Mar 2017

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    Laser-Doppler Flowmetry
    Stroke
    Clinical Trials
    Cerebrovascular Disorders
    Wavelet Analysis
    Calcium Signaling
    Forehead
    Thrombolytic Therapy
    Arterioles
    Microcirculation
    Microvessels
    Vascular Smooth Muscle
    Smooth Muscle Myocytes
    Perfusion
    Hemodynamics
    Observation

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    Goltsov, Alexey ; Anisimova, Anastasia ; Zakharkina, Maria ; Krupatkin, Alexander I. ; Sidorov, Viktor V. ; Sokolovski, Sergei G. ; Rafailov, Edik. / Bifurcation in blood oscillatory rhythms for patients with ischemic stroke : a small scale clinical trial using laser Doppler flowmetry and computational modelling of vasomotion. In: Frontiers in Physiology. 2017 ; Vol. 8.
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    abstract = "We describe application of spectral analysis of laser Doppler flowmetry (LDF) signals to investigation of cerebrovascular haemodynamics in patients with post-acute ischemic stroke (AIS) and cerebrovascular insufficiency. LDF was performed from 3 to 7 days after the onset of AIS on forehead in the right and left supraorbital regions in patients. Analysis of LDF signals showed that perfusion in the microvasculature in AIS patients was lower than that in patients with cerebrovascular insufficiency. As a result of wavelet analysis of the LDF signals we obtained activation of the vasomotion in the frequency range of myogenic oscillation of 0.1 Hz and predominantly nutritive regime microcirculation after systemic thrombolytic therapy of the AIS patients. In case of significant stroke size, myogenic activity and nutritive pattern microhaemodynamics were reduced, in some cases non-nutritive pattern and/or venular stasis was revealed. Wavelet analysis of the LDF signals also showed asymmetry in wavelet spectra of the LDF signals obtained in stroke-affected and unaffected hemispheres in the AIS patients. A mechanism underlying the observed asymmetry was analysed by computational modelling of vasomotion developed in (Arciero & Secomb, 2012). We applied this model to describe relaxation oscillation of arteriole diameter which is forced by myogenic oscillation induced by synchronous calcium oscillation in vascular smooth muscle cells. Calculation showed that vasomotion frequency spectrum at the low-frequency range (0.01 Hz) is reciprocally modulated by myogenic oscillation (0.1 Hz) that correlates with experimental observation of inter-hemispheric variation in the LDF spectrum.",
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    Bifurcation in blood oscillatory rhythms for patients with ischemic stroke : a small scale clinical trial using laser Doppler flowmetry and computational modelling of vasomotion. / Goltsov, Alexey; Anisimova, Anastasia; Zakharkina, Maria; Krupatkin, Alexander I.; Sidorov, Viktor V.; Sokolovski, Sergei G.; Rafailov, Edik.

    In: Frontiers in Physiology, Vol. 8, 160, 23.03.2017.

    Research output: Contribution to journalArticle

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    T2 - a small scale clinical trial using laser Doppler flowmetry and computational modelling of vasomotion

    AU - Goltsov, Alexey

    AU - Anisimova, Anastasia

    AU - Zakharkina, Maria

    AU - Krupatkin, Alexander I.

    AU - Sidorov, Viktor V.

    AU - Sokolovski, Sergei G.

    AU - Rafailov, Edik

    PY - 2017/3/23

    Y1 - 2017/3/23

    N2 - We describe application of spectral analysis of laser Doppler flowmetry (LDF) signals to investigation of cerebrovascular haemodynamics in patients with post-acute ischemic stroke (AIS) and cerebrovascular insufficiency. LDF was performed from 3 to 7 days after the onset of AIS on forehead in the right and left supraorbital regions in patients. Analysis of LDF signals showed that perfusion in the microvasculature in AIS patients was lower than that in patients with cerebrovascular insufficiency. As a result of wavelet analysis of the LDF signals we obtained activation of the vasomotion in the frequency range of myogenic oscillation of 0.1 Hz and predominantly nutritive regime microcirculation after systemic thrombolytic therapy of the AIS patients. In case of significant stroke size, myogenic activity and nutritive pattern microhaemodynamics were reduced, in some cases non-nutritive pattern and/or venular stasis was revealed. Wavelet analysis of the LDF signals also showed asymmetry in wavelet spectra of the LDF signals obtained in stroke-affected and unaffected hemispheres in the AIS patients. A mechanism underlying the observed asymmetry was analysed by computational modelling of vasomotion developed in (Arciero & Secomb, 2012). We applied this model to describe relaxation oscillation of arteriole diameter which is forced by myogenic oscillation induced by synchronous calcium oscillation in vascular smooth muscle cells. Calculation showed that vasomotion frequency spectrum at the low-frequency range (0.01 Hz) is reciprocally modulated by myogenic oscillation (0.1 Hz) that correlates with experimental observation of inter-hemispheric variation in the LDF spectrum.

    AB - We describe application of spectral analysis of laser Doppler flowmetry (LDF) signals to investigation of cerebrovascular haemodynamics in patients with post-acute ischemic stroke (AIS) and cerebrovascular insufficiency. LDF was performed from 3 to 7 days after the onset of AIS on forehead in the right and left supraorbital regions in patients. Analysis of LDF signals showed that perfusion in the microvasculature in AIS patients was lower than that in patients with cerebrovascular insufficiency. As a result of wavelet analysis of the LDF signals we obtained activation of the vasomotion in the frequency range of myogenic oscillation of 0.1 Hz and predominantly nutritive regime microcirculation after systemic thrombolytic therapy of the AIS patients. In case of significant stroke size, myogenic activity and nutritive pattern microhaemodynamics were reduced, in some cases non-nutritive pattern and/or venular stasis was revealed. Wavelet analysis of the LDF signals also showed asymmetry in wavelet spectra of the LDF signals obtained in stroke-affected and unaffected hemispheres in the AIS patients. A mechanism underlying the observed asymmetry was analysed by computational modelling of vasomotion developed in (Arciero & Secomb, 2012). We applied this model to describe relaxation oscillation of arteriole diameter which is forced by myogenic oscillation induced by synchronous calcium oscillation in vascular smooth muscle cells. Calculation showed that vasomotion frequency spectrum at the low-frequency range (0.01 Hz) is reciprocally modulated by myogenic oscillation (0.1 Hz) that correlates with experimental observation of inter-hemispheric variation in the LDF spectrum.

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    JO - Frontiers in Physiology

    JF - Frontiers in Physiology

    SN - 1664-042X

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