Biomaterial aided differentiation and maturation of induced pluripotent stem cells

Bharath Kumar Velmurugan*, Lohanathan Bharathi Priya, Poornima Paramasivan, Li-Jen Lee, Rathinasamy Baskaran

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Engineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self‐renewal and differentiation potential, these iPSC are aspired to meet the growing demands in the field of regenerative medicine, tissue engineering, disease modeling, nanotechnology, and drug discovery. Biomaterial fabrication with the rapid evolution of technology increased their versatility and utility in regenerative medicine and tissue engineering, revolutionizing the stem cell biology research with the property to guide the process of proliferation, differentiation, and morphogenesis. Combining traditional culture platforms of iPSC with biomaterials aids to overcome the limitations associated with derivation, proliferation, and maturation, thereby could improve the clinical translation of iPSC. The present review discusses in brief about the reprogramming techniques for the derivation iPSC and details on several biomaterial guided differentiation of iPSC to different cell types with specific relevance to tissue engineering/regenerative medicine.
Original languageEnglish
Pages (from-to)8443-8454
Number of pages12
JournalJournal of Cellular Physiology
Volume234
Issue number6
Early online date22 Nov 2018
DOIs
Publication statusPublished - 30 Jun 2019

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Induced Pluripotent Stem Cells
Biocompatible Materials
Stem cells
Regenerative Medicine
Tissue Engineering
Tissue engineering
Stem Cell Research
Cytology
Nanotechnology
Cell Lineage
Drug Discovery
Morphogenesis
Cell Biology
Cell culture
Technology
Fabrication

Cite this

Velmurugan, Bharath Kumar ; Priya, Lohanathan Bharathi ; Paramasivan, Poornima ; Lee, Li-Jen ; Baskaran, Rathinasamy. / Biomaterial aided differentiation and maturation of induced pluripotent stem cells. In: Journal of Cellular Physiology. 2019 ; Vol. 234, No. 6. pp. 8443-8454.
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Biomaterial aided differentiation and maturation of induced pluripotent stem cells. / Velmurugan, Bharath Kumar; Priya, Lohanathan Bharathi; Paramasivan, Poornima; Lee, Li-Jen; Baskaran, Rathinasamy.

In: Journal of Cellular Physiology, Vol. 234, No. 6, 30.06.2019, p. 8443-8454.

Research output: Contribution to journalReview article

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AU - Velmurugan, Bharath Kumar

AU - Priya, Lohanathan Bharathi

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AU - Lee, Li-Jen

AU - Baskaran, Rathinasamy

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AB - Engineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self‐renewal and differentiation potential, these iPSC are aspired to meet the growing demands in the field of regenerative medicine, tissue engineering, disease modeling, nanotechnology, and drug discovery. Biomaterial fabrication with the rapid evolution of technology increased their versatility and utility in regenerative medicine and tissue engineering, revolutionizing the stem cell biology research with the property to guide the process of proliferation, differentiation, and morphogenesis. Combining traditional culture platforms of iPSC with biomaterials aids to overcome the limitations associated with derivation, proliferation, and maturation, thereby could improve the clinical translation of iPSC. The present review discusses in brief about the reprogramming techniques for the derivation iPSC and details on several biomaterial guided differentiation of iPSC to different cell types with specific relevance to tissue engineering/regenerative medicine.

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