Biomaterial aided differentiation and maturation of induced pluripotent stem cells

Bharath Kumar Velmurugan*, Lohanathan Bharathi Priya, Poornima Paramasivan, Li-Jen Lee, Rathinasamy Baskaran

*Corresponding author for this work

    Research output: Contribution to journalReview article

    Abstract

    Engineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self‐renewal and differentiation potential, these iPSC are aspired to meet the growing demands in the field of regenerative medicine, tissue engineering, disease modeling, nanotechnology, and drug discovery. Biomaterial fabrication with the rapid evolution of technology increased their versatility and utility in regenerative medicine and tissue engineering, revolutionizing the stem cell biology research with the property to guide the process of proliferation, differentiation, and morphogenesis. Combining traditional culture platforms of iPSC with biomaterials aids to overcome the limitations associated with derivation, proliferation, and maturation, thereby could improve the clinical translation of iPSC. The present review discusses in brief about the reprogramming techniques for the derivation iPSC and details on several biomaterial guided differentiation of iPSC to different cell types with specific relevance to tissue engineering/regenerative medicine.
    Original languageEnglish
    Pages (from-to)8443-8454
    Number of pages12
    JournalJournal of Cellular Physiology
    Volume234
    Issue number6
    Early online date22 Nov 2018
    DOIs
    Publication statusPublished - 30 Jun 2019

    Fingerprint

    Induced Pluripotent Stem Cells
    Biocompatible Materials
    Stem cells
    Regenerative Medicine
    Tissue Engineering
    Tissue engineering
    Stem Cell Research
    Cytology
    Nanotechnology
    Cell Lineage
    Drug Discovery
    Morphogenesis
    Cell Biology
    Cell culture
    Technology
    Fabrication

    Cite this

    Velmurugan, Bharath Kumar ; Priya, Lohanathan Bharathi ; Paramasivan, Poornima ; Lee, Li-Jen ; Baskaran, Rathinasamy. / Biomaterial aided differentiation and maturation of induced pluripotent stem cells. In: Journal of Cellular Physiology. 2019 ; Vol. 234, No. 6. pp. 8443-8454.
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    abstract = "Engineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self‐renewal and differentiation potential, these iPSC are aspired to meet the growing demands in the field of regenerative medicine, tissue engineering, disease modeling, nanotechnology, and drug discovery. Biomaterial fabrication with the rapid evolution of technology increased their versatility and utility in regenerative medicine and tissue engineering, revolutionizing the stem cell biology research with the property to guide the process of proliferation, differentiation, and morphogenesis. Combining traditional culture platforms of iPSC with biomaterials aids to overcome the limitations associated with derivation, proliferation, and maturation, thereby could improve the clinical translation of iPSC. The present review discusses in brief about the reprogramming techniques for the derivation iPSC and details on several biomaterial guided differentiation of iPSC to different cell types with specific relevance to tissue engineering/regenerative medicine.",
    author = "Velmurugan, {Bharath Kumar} and Priya, {Lohanathan Bharathi} and Poornima Paramasivan and Li-Jen Lee and Rathinasamy Baskaran",
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    Biomaterial aided differentiation and maturation of induced pluripotent stem cells. / Velmurugan, Bharath Kumar; Priya, Lohanathan Bharathi; Paramasivan, Poornima; Lee, Li-Jen; Baskaran, Rathinasamy.

    In: Journal of Cellular Physiology, Vol. 234, No. 6, 30.06.2019, p. 8443-8454.

    Research output: Contribution to journalReview article

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    T1 - Biomaterial aided differentiation and maturation of induced pluripotent stem cells

    AU - Velmurugan, Bharath Kumar

    AU - Priya, Lohanathan Bharathi

    AU - Paramasivan, Poornima

    AU - Lee, Li-Jen

    AU - Baskaran, Rathinasamy

    PY - 2019/6/30

    Y1 - 2019/6/30

    N2 - Engineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self‐renewal and differentiation potential, these iPSC are aspired to meet the growing demands in the field of regenerative medicine, tissue engineering, disease modeling, nanotechnology, and drug discovery. Biomaterial fabrication with the rapid evolution of technology increased their versatility and utility in regenerative medicine and tissue engineering, revolutionizing the stem cell biology research with the property to guide the process of proliferation, differentiation, and morphogenesis. Combining traditional culture platforms of iPSC with biomaterials aids to overcome the limitations associated with derivation, proliferation, and maturation, thereby could improve the clinical translation of iPSC. The present review discusses in brief about the reprogramming techniques for the derivation iPSC and details on several biomaterial guided differentiation of iPSC to different cell types with specific relevance to tissue engineering/regenerative medicine.

    AB - Engineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self‐renewal and differentiation potential, these iPSC are aspired to meet the growing demands in the field of regenerative medicine, tissue engineering, disease modeling, nanotechnology, and drug discovery. Biomaterial fabrication with the rapid evolution of technology increased their versatility and utility in regenerative medicine and tissue engineering, revolutionizing the stem cell biology research with the property to guide the process of proliferation, differentiation, and morphogenesis. Combining traditional culture platforms of iPSC with biomaterials aids to overcome the limitations associated with derivation, proliferation, and maturation, thereby could improve the clinical translation of iPSC. The present review discusses in brief about the reprogramming techniques for the derivation iPSC and details on several biomaterial guided differentiation of iPSC to different cell types with specific relevance to tissue engineering/regenerative medicine.

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