Biomaterial aided differentiation and maturation of induced pluripotent stem cells

Bharath Kumar Velmurugan*, Lohanathan Bharathi Priya, Poornima Paramasivan, Li-Jen Lee, Rathinasamy Baskaran

*Corresponding author for this work

    Research output: Contribution to journalReview article

    2 Citations (Scopus)

    Abstract

    Engineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self‐renewal and differentiation potential, these iPSC are aspired to meet the growing demands in the field of regenerative medicine, tissue engineering, disease modeling, nanotechnology, and drug discovery. Biomaterial fabrication with the rapid evolution of technology increased their versatility and utility in regenerative medicine and tissue engineering, revolutionizing the stem cell biology research with the property to guide the process of proliferation, differentiation, and morphogenesis. Combining traditional culture platforms of iPSC with biomaterials aids to overcome the limitations associated with derivation, proliferation, and maturation, thereby could improve the clinical translation of iPSC. The present review discusses in brief about the reprogramming techniques for the derivation iPSC and details on several biomaterial guided differentiation of iPSC to different cell types with specific relevance to tissue engineering/regenerative medicine.
    Original languageEnglish
    Pages (from-to)8443-8454
    Number of pages12
    JournalJournal of Cellular Physiology
    Volume234
    Issue number6
    Early online date22 Nov 2018
    DOIs
    Publication statusPublished - 30 Jun 2019

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