Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 935-942 |
| Number of pages | 8 |
| Journal | Medicine & Science in Sports & Exercise |
| Volume | 43 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2011 |
Fingerprint
Cite this
}
Cardiac output is not related to the slowed O2 uptake kinetics in type 2 diabetes. / Mac Ananey, Oscar; Malone, John K.; Warmington, Stuart; O'Shea, Donal; Green, Simon; Egana, Mikel.
In: Medicine & Science in Sports & Exercise, Vol. 43, No. 6, 06.2011, p. 935-942.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cardiac output is not related to the slowed O2 uptake kinetics in type 2 diabetes
AU - Mac Ananey, Oscar
AU - Malone, John K.
AU - Warmington, Stuart
AU - O'Shea, Donal
AU - Green, Simon
AU - Egana, Mikel
PY - 2011/6
Y1 - 2011/6
N2 - Purpose: This study aimed to investigate whether cardiac output (CO) responses were related to V˙O2 kinetics during cycling in type 2 diabetes. Methods: A total of 9 middle-aged women with uncomplicated type 2 diabetes, 9 nondiabetic overweight women, and 11 nondiabetic lean women were recruited. Initially, the ventilatory threshold (VT) and peak V˙O2 were determined during a maximal graded test. Then, on two separate days, subjects completed three 7-min bouts of constant-load cycling at each of three intensities: 50% VT, 80% VT, and midpoint between VT and peak V˙O2 (50% Δ). CO (inert gas rebreathing) was recorded at 30 and 240 s of an additional bout at each intensity. V˙O2 kinetic parameters were determined by fitting a biexponential (50% VT and 80% VT) or triexponential (50% Δ) function to the V˙O2 data. Results: Peak V˙O2 was significantly lower in type 2 diabetes compared with the two nondiabetic groups (P < 0.05). The time constant of phase 2 was significantly greater (P < 0.05) in type 2 diabetes compared with the nondiabetic heavy and lean groups at 50% VT (34.2 ± 15.7 vs 15.4 ± 7.3 and 20.2 ± 9.7 s) and 80% VT (39.1 ± 9.0 vs 24.8 ± 8.8 and 36.8 ± 7.9 s), but none of the V˙O2 kinetic parameters were different at 50% Δ. CO responses during exercise were not different among the three groups, and at 80% VT, the change in CO from 30 to 240 s was significantly larger in type 2 diabetes compared with the two nondiabetic groups. Conclusions: The results confirm that type 2 diabetes slows the dynamic response of V˙O2 during light and moderate relative intensity exercise in females but that this occurs in the absence of any slowing of the CO response during the initial period of exercise.
AB - Purpose: This study aimed to investigate whether cardiac output (CO) responses were related to V˙O2 kinetics during cycling in type 2 diabetes. Methods: A total of 9 middle-aged women with uncomplicated type 2 diabetes, 9 nondiabetic overweight women, and 11 nondiabetic lean women were recruited. Initially, the ventilatory threshold (VT) and peak V˙O2 were determined during a maximal graded test. Then, on two separate days, subjects completed three 7-min bouts of constant-load cycling at each of three intensities: 50% VT, 80% VT, and midpoint between VT and peak V˙O2 (50% Δ). CO (inert gas rebreathing) was recorded at 30 and 240 s of an additional bout at each intensity. V˙O2 kinetic parameters were determined by fitting a biexponential (50% VT and 80% VT) or triexponential (50% Δ) function to the V˙O2 data. Results: Peak V˙O2 was significantly lower in type 2 diabetes compared with the two nondiabetic groups (P < 0.05). The time constant of phase 2 was significantly greater (P < 0.05) in type 2 diabetes compared with the nondiabetic heavy and lean groups at 50% VT (34.2 ± 15.7 vs 15.4 ± 7.3 and 20.2 ± 9.7 s) and 80% VT (39.1 ± 9.0 vs 24.8 ± 8.8 and 36.8 ± 7.9 s), but none of the V˙O2 kinetic parameters were different at 50% Δ. CO responses during exercise were not different among the three groups, and at 80% VT, the change in CO from 30 to 240 s was significantly larger in type 2 diabetes compared with the two nondiabetic groups. Conclusions: The results confirm that type 2 diabetes slows the dynamic response of V˙O2 during light and moderate relative intensity exercise in females but that this occurs in the absence of any slowing of the CO response during the initial period of exercise.
U2 - 10.1249/MSS.0b013e3182061cdb
DO - 10.1249/MSS.0b013e3182061cdb
M3 - Article
VL - 43
SP - 935
EP - 942
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
SN - 0195-9131
IS - 6
ER -