Cardiac output is not related to the slowed O2 uptake kinetics in type 2 diabetes

Oscar Mac Ananey, John K. Malone, Stuart Warmington, Donal O'Shea, Simon Green, Mikel Egana

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Purpose: This study aimed to investigate whether cardiac output (CO) responses were related to V˙O2 kinetics during cycling in type 2 diabetes. Methods: A total of 9 middle-aged women with uncomplicated type 2 diabetes, 9 nondiabetic overweight women, and 11 nondiabetic lean women were recruited. Initially, the ventilatory threshold (VT) and peak V˙O2 were determined during a maximal graded test. Then, on two separate days, subjects completed three 7-min bouts of constant-load cycling at each of three intensities: 50% VT, 80% VT, and midpoint between VT and peak V˙O2 (50% Δ). CO (inert gas rebreathing) was recorded at 30 and 240 s of an additional bout at each intensity. V˙O2 kinetic parameters were determined by fitting a biexponential (50% VT and 80% VT) or triexponential (50% Δ) function to the V˙O2 data. Results: Peak V˙O2 was significantly lower in type 2 diabetes compared with the two nondiabetic groups (P < 0.05). The time constant of phase 2 was significantly greater (P < 0.05) in type 2 diabetes compared with the nondiabetic heavy and lean groups at 50% VT (34.2 ± 15.7 vs 15.4 ± 7.3 and 20.2 ± 9.7 s) and 80% VT (39.1 ± 9.0 vs 24.8 ± 8.8 and 36.8 ± 7.9 s), but none of the V˙O2 kinetic parameters were different at 50% Δ. CO responses during exercise were not different among the three groups, and at 80% VT, the change in CO from 30 to 240 s was significantly larger in type 2 diabetes compared with the two nondiabetic groups. Conclusions: The results confirm that type 2 diabetes slows the dynamic response of V˙O2 during light and moderate relative intensity exercise in females but that this occurs in the absence of any slowing of the CO response during the initial period of exercise.
Original languageEnglish
Pages (from-to)935-942
Number of pages8
JournalMedicine & Science in Sports & Exercise
Issue number6
Publication statusPublished - Jun 2011
Externally publishedYes


  • Cardiac output
  • O2 uptake kinetics
  • Type 2 diabetes
  • Women
  • Cycling


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