Cellular modelling of electrical remodelling in two different models of human atrial myocytes

H. Zhang, Jiujiang Zhu, C. J. Garratt, A. V. Holden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

  • 8 Citations

Abstract

Changes in action potentials of atrial myocytes and various ionic channels induced by chronic atrial fibrillation (AF) have been described in the human. The mechanisms underlying the AF-induced action potential duration (APD) shortening have not been clearly identified. In this study we modify two different computational models of electrical activity of human atrial myocytes by incorporating chronic AF induced changes in several of the ionic channels systems found in myocytes. We examine the ionic mechanisms underlying the AF induced APD reduction and the relative roles of different remodeled ionic channels in producing the APD reduction. In both models we have found that AF induced changes in the ionic channel conductances and kinetics are able to reproduce the APD reduction seen experimentally. AF-induced down regulation of L-type Ca current is insufficient to account for the observed APD reduction, but up regulation of IKl has a much greater influence.
Original languageEnglish
Title of host publicationComputers in Cardiology, 2003
EditorsAlan Murray
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages777-780
Number of pages4
Volume30
ISBN (Print)078038170X
DOIs
StatePublished - Sep 2003
EventComputers in Cardiology - Thessaloniki, Greece

Conference

ConferenceComputers in Cardiology
Abbreviated titleCinC
CountryGreece
CityThessaloniki
Period21/09/0324/09/03

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Atrial Remodeling
Atrial Fibrillation
Action Potentials
Ion Channels
Up-Regulation
Down-Regulation

Cite this

Zhang, H., Zhu, J., Garratt, C. J., & Holden, A. V. (2003). Cellular modelling of electrical remodelling in two different models of human atrial myocytes. In A. Murray (Ed.), Computers in Cardiology, 2003 (Vol. 30, pp. 777-780). Piscataway, NJ: IEEE . DOI: 10.1109/CIC.2003.1291272

Zhang, H.; Zhu, Jiujiang; Garratt, C. J.; Holden, A. V. / Cellular modelling of electrical remodelling in two different models of human atrial myocytes.

Computers in Cardiology, 2003. ed. / Alan Murray. Vol. 30 Piscataway, NJ : IEEE , 2003. p. 777-780.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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abstract = "Changes in action potentials of atrial myocytes and various ionic channels induced by chronic atrial fibrillation (AF) have been described in the human. The mechanisms underlying the AF-induced action potential duration (APD) shortening have not been clearly identified. In this study we modify two different computational models of electrical activity of human atrial myocytes by incorporating chronic AF induced changes in several of the ionic channels systems found in myocytes. We examine the ionic mechanisms underlying the AF induced APD reduction and the relative roles of different remodeled ionic channels in producing the APD reduction. In both models we have found that AF induced changes in the ionic channel conductances and kinetics are able to reproduce the APD reduction seen experimentally. AF-induced down regulation of L-type Ca current is insufficient to account for the observed APD reduction, but up regulation of IKl has a much greater influence.",
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Zhang, H, Zhu, J, Garratt, CJ & Holden, AV 2003, Cellular modelling of electrical remodelling in two different models of human atrial myocytes. in A Murray (ed.), Computers in Cardiology, 2003. vol. 30, IEEE , Piscataway, NJ, pp. 777-780, Computers in Cardiology, Thessaloniki, Greece, 21-24 September. DOI: 10.1109/CIC.2003.1291272

Cellular modelling of electrical remodelling in two different models of human atrial myocytes. / Zhang, H.; Zhu, Jiujiang; Garratt, C. J.; Holden, A. V.

Computers in Cardiology, 2003. ed. / Alan Murray. Vol. 30 Piscataway, NJ : IEEE , 2003. p. 777-780.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - Changes in action potentials of atrial myocytes and various ionic channels induced by chronic atrial fibrillation (AF) have been described in the human. The mechanisms underlying the AF-induced action potential duration (APD) shortening have not been clearly identified. In this study we modify two different computational models of electrical activity of human atrial myocytes by incorporating chronic AF induced changes in several of the ionic channels systems found in myocytes. We examine the ionic mechanisms underlying the AF induced APD reduction and the relative roles of different remodeled ionic channels in producing the APD reduction. In both models we have found that AF induced changes in the ionic channel conductances and kinetics are able to reproduce the APD reduction seen experimentally. AF-induced down regulation of L-type Ca current is insufficient to account for the observed APD reduction, but up regulation of IKl has a much greater influence.

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BT - Computers in Cardiology, 2003

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Zhang H, Zhu J, Garratt CJ, Holden AV. Cellular modelling of electrical remodelling in two different models of human atrial myocytes. In Murray A, editor, Computers in Cardiology, 2003. Vol. 30. Piscataway, NJ: IEEE . 2003. p. 777-780. Available from, DOI: 10.1109/CIC.2003.1291272