Cellular modelling of electrical remodelling in two different models of human atrial myocytes

H. Zhang; Jiujiang Zhu; C. J. Garratt; A. V. Holden

doi:10.1109/CIC.2003.1291272

Cellular modelling of electrical remodelling in two different models of human atrial myocytes

H. Zhang, Jiujiang Zhu, C. J. Garratt, A. V. Holden

Abertay University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

8 Citations (Scopus)

Abstract

Changes in action potentials of atrial myocytes and various ionic channels induced by chronic atrial fibrillation (AF) have been described in the human. The mechanisms underlying the AF-induced action potential duration (APD) shortening have not been clearly identified. In this study we modify two different computational models of electrical activity of human atrial myocytes by incorporating chronic AF induced changes in several of the ionic channels systems found in myocytes. We examine the ionic mechanisms underlying the AF induced APD reduction and the relative roles of different remodeled ionic channels in producing the APD reduction. In both models we have found that AF induced changes in the ionic channel conductances and kinetics are able to reproduce the APD reduction seen experimentally. AF-induced down regulation of L-type Ca current is insufficient to account for the observed APD reduction, but up regulation of IKl has a much greater influence.

Original language	English
Title of host publication	Computers in Cardiology, 2003
Editors	Alan Murray
Place of Publication	Piscataway, NJ
Publisher	IEEE
Pages	777-780
Number of pages	4
Volume	30
ISBN (Print)	078038170X
DOIs	https://doi.org/10.1109/CIC.2003.1291272
Publication status	Published - Sep 2003
Event	Computers in Cardiology - Thessaloniki, Greece Duration: 21 Sep 2003 → 24 Sep 2003 Conference number: 30

Conference

Conference	Computers in Cardiology
Abbreviated title	CinC
Country	Greece
City	Thessaloniki
Period	21/09/03 → 24/09/03

Access to Document

10.1109/CIC.2003.1291272

http://www.cinc.org/archives/2003/pdf/777.pdf

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Cite this

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title = "Cellular modelling of electrical remodelling in two different models of human atrial myocytes",

abstract = "Changes in action potentials of atrial myocytes and various ionic channels induced by chronic atrial fibrillation (AF) have been described in the human. The mechanisms underlying the AF-induced action potential duration (APD) shortening have not been clearly identified. In this study we modify two different computational models of electrical activity of human atrial myocytes by incorporating chronic AF induced changes in several of the ionic channels systems found in myocytes. We examine the ionic mechanisms underlying the AF induced APD reduction and the relative roles of different remodeled ionic channels in producing the APD reduction. In both models we have found that AF induced changes in the ionic channel conductances and kinetics are able to reproduce the APD reduction seen experimentally. AF-induced down regulation of L-type Ca current is insufficient to account for the observed APD reduction, but up regulation of IKl has a much greater influence.",

author = "H. Zhang and Jiujiang Zhu and Garratt, {C. J.} and Holden, {A. V.}",

year = "2003",

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AU - Zhu, Jiujiang

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N2 - Changes in action potentials of atrial myocytes and various ionic channels induced by chronic atrial fibrillation (AF) have been described in the human. The mechanisms underlying the AF-induced action potential duration (APD) shortening have not been clearly identified. In this study we modify two different computational models of electrical activity of human atrial myocytes by incorporating chronic AF induced changes in several of the ionic channels systems found in myocytes. We examine the ionic mechanisms underlying the AF induced APD reduction and the relative roles of different remodeled ionic channels in producing the APD reduction. In both models we have found that AF induced changes in the ionic channel conductances and kinetics are able to reproduce the APD reduction seen experimentally. AF-induced down regulation of L-type Ca current is insufficient to account for the observed APD reduction, but up regulation of IKl has a much greater influence.

AB - Changes in action potentials of atrial myocytes and various ionic channels induced by chronic atrial fibrillation (AF) have been described in the human. The mechanisms underlying the AF-induced action potential duration (APD) shortening have not been clearly identified. In this study we modify two different computational models of electrical activity of human atrial myocytes by incorporating chronic AF induced changes in several of the ionic channels systems found in myocytes. We examine the ionic mechanisms underlying the AF induced APD reduction and the relative roles of different remodeled ionic channels in producing the APD reduction. In both models we have found that AF induced changes in the ionic channel conductances and kinetics are able to reproduce the APD reduction seen experimentally. AF-induced down regulation of L-type Ca current is insufficient to account for the observed APD reduction, but up regulation of IKl has a much greater influence.

U2 - 10.1109/CIC.2003.1291272

DO - 10.1109/CIC.2003.1291272

M3 - Conference contribution

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BT - Computers in Cardiology, 2003

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