Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation

H. Zhang; Jiujiang Zhu; C. J. Garratt; A. V. Holden

doi:10.1109/CIC.2004.1442891

Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation

H. Zhang, Jiujiang Zhu, C. J. Garratt, A. V. Holden

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Chronic atrial fibrillation (AF) induces remodelling of both channel conductance and intercellular coupling in the human atrium. Effects of these changes and their relative contributions to atrial impulse conduction during fibrillation are unknown. In this study we constructed a virtual human atrial strand by incorporating the Nygren et al model of human atrial action potential into a 1-dimensional reaction diffusion partial differential equation. Experimental data on AF-induced changes of human atrial ionic channel conductances and kinetics and gap junction coupling were incorporated into a model to investigate their contributions and relative importance on conduction velocity (CV) at different rates. At low rates (stimulus interval SI>270 ms), AF-induced channel or gap junction remodelling reduced CV significantly. At high rates (SI<270 ms), channel remodelling increased CV while gap junction remodelling reduced the CV. When combined, channel and gap junction remodelling reduced CV additively. Spatial heterogeneities in gap junction coupling can produce intermittent conduction block.

Original language	English
Title of host publication	Computers in Cardiology 2004
Editors	Alan Murray
Place of Publication	Piscataway, NJ
Publisher	IEEE
Pages	141-144
Number of pages	4
Volume	31
ISBN (Print)	0780389271
DOIs	https://doi.org/10.1109/CIC.2004.1442891
Publication status	Published - Sep 2004
Externally published	Yes
Event	Computing in Cardiology - Chicago, United States Duration: 19 Sep 2004 → 22 Sep 2004 Conference number: 31

Conference

Conference	Computing in Cardiology
Abbreviated title	CinC
Country/Territory	United States
City	Chicago
Period	19/09/04 → 22/09/04

Keywords

Bioelectric potentials
Biomembrane transport
Blood vessels
Cardiovascular system
Diseases
Partial differential equations
Reaction-diffusion systems

Access to Document

10.1109/CIC.2004.1442891

Cite this

@inproceedings{15812f2ac9514fb1ad87cabb07a20877,

title = "Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation",

abstract = "Chronic atrial fibrillation (AF) induces remodelling of both channel conductance and intercellular coupling in the human atrium. Effects of these changes and their relative contributions to atrial impulse conduction during fibrillation are unknown. In this study we constructed a virtual human atrial strand by incorporating the Nygren et al model of human atrial action potential into a 1-dimensional reaction diffusion partial differential equation. Experimental data on AF-induced changes of human atrial ionic channel conductances and kinetics and gap junction coupling were incorporated into a model to investigate their contributions and relative importance on conduction velocity (CV) at different rates. At low rates (stimulus interval SI>270 ms), AF-induced channel or gap junction remodelling reduced CV significantly. At high rates (SI<270 ms), channel remodelling increased CV while gap junction remodelling reduced the CV. When combined, channel and gap junction remodelling reduced CV additively. Spatial heterogeneities in gap junction coupling can produce intermittent conduction block.",

author = "H. Zhang and Jiujiang Zhu and Garratt, {C. J.} and Holden, {A. V.}",

year = "2004",

month = sep,

doi = "10.1109/CIC.2004.1442891",

language = "English",

isbn = "0780389271",

volume = "31",

pages = "141--144",

editor = "Alan Murray",

booktitle = "Computers in Cardiology 2004",

publisher = "IEEE ",

note = "Computing in Cardiology, CinC ; Conference date: 19-09-2004 Through 22-09-2004",

}

Zhang, H, Zhu, J, Garratt, CJ & Holden, AV 2004, Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation. in A Murray (ed.), Computers in Cardiology 2004. vol. 31, IEEE , Piscataway, NJ, pp. 141-144, Computing in Cardiology, Chicago, Illinois, United States, 19/09/04. https://doi.org/10.1109/CIC.2004.1442891

Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation. / Zhang, H.; Zhu, Jiujiang; Garratt, C. J. et al.

Computers in Cardiology 2004. ed. / Alan Murray. Vol. 31 Piscataway, NJ : IEEE , 2004. p. 141-144.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation

AU - Zhang, H.

AU - Zhu, Jiujiang

AU - Garratt, C. J.

AU - Holden, A. V.

N1 - Conference code: 31

PY - 2004/9

Y1 - 2004/9

N2 - Chronic atrial fibrillation (AF) induces remodelling of both channel conductance and intercellular coupling in the human atrium. Effects of these changes and their relative contributions to atrial impulse conduction during fibrillation are unknown. In this study we constructed a virtual human atrial strand by incorporating the Nygren et al model of human atrial action potential into a 1-dimensional reaction diffusion partial differential equation. Experimental data on AF-induced changes of human atrial ionic channel conductances and kinetics and gap junction coupling were incorporated into a model to investigate their contributions and relative importance on conduction velocity (CV) at different rates. At low rates (stimulus interval SI>270 ms), AF-induced channel or gap junction remodelling reduced CV significantly. At high rates (SI<270 ms), channel remodelling increased CV while gap junction remodelling reduced the CV. When combined, channel and gap junction remodelling reduced CV additively. Spatial heterogeneities in gap junction coupling can produce intermittent conduction block.

AB - Chronic atrial fibrillation (AF) induces remodelling of both channel conductance and intercellular coupling in the human atrium. Effects of these changes and their relative contributions to atrial impulse conduction during fibrillation are unknown. In this study we constructed a virtual human atrial strand by incorporating the Nygren et al model of human atrial action potential into a 1-dimensional reaction diffusion partial differential equation. Experimental data on AF-induced changes of human atrial ionic channel conductances and kinetics and gap junction coupling were incorporated into a model to investigate their contributions and relative importance on conduction velocity (CV) at different rates. At low rates (stimulus interval SI>270 ms), AF-induced channel or gap junction remodelling reduced CV significantly. At high rates (SI<270 ms), channel remodelling increased CV while gap junction remodelling reduced the CV. When combined, channel and gap junction remodelling reduced CV additively. Spatial heterogeneities in gap junction coupling can produce intermittent conduction block.

U2 - 10.1109/CIC.2004.1442891

DO - 10.1109/CIC.2004.1442891

M3 - Conference contribution

SN - 0780389271

VL - 31

SP - 141

EP - 144

BT - Computers in Cardiology 2004

A2 - Murray, Alan

PB - IEEE

CY - Piscataway, NJ

T2 - Computing in Cardiology

Y2 - 19 September 2004 through 22 September 2004

ER -

Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation

Abstract

Conference

Keywords

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