Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation

H. Zhang, Jiujiang Zhu, C. J. Garratt, A. V. Holden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Chronic atrial fibrillation (AF) induces remodelling of both channel conductance and intercellular coupling in the human atrium. Effects of these changes and their relative contributions to atrial impulse conduction during fibrillation are unknown. In this study we constructed a virtual human atrial strand by incorporating the Nygren et al model of human atrial action potential into a 1-dimensional reaction diffusion partial differential equation. Experimental data on AF-induced changes of human atrial ionic channel conductances and kinetics and gap junction coupling were incorporated into a model to investigate their contributions and relative importance on conduction velocity (CV) at different rates. At low rates (stimulus interval SI>270 ms), AF-induced channel or gap junction remodelling reduced CV significantly. At high rates (SI<270 ms), channel remodelling increased CV while gap junction remodelling reduced the CV. When combined, channel and gap junction remodelling reduced CV additively. Spatial heterogeneities in gap junction coupling can produce intermittent conduction block.
Original languageEnglish
Title of host publicationComputers in Cardiology 2004
EditorsAlan Murray
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages141-144
Number of pages4
Volume31
ISBN (Print)0780389271
DOIs
StatePublished - Sep 2004
EventComputing in Cardiology - Chicago, United States

Conference

ConferenceComputing in Cardiology
Abbreviated titleCinC
CountryUnited States
CityChicago
Period19/09/0422/09/04

Fingerprint

Gap Junctions
Atrial Fibrillation
Ion Channels
Action Potentials

Cite this

Zhang, H., Zhu, J., Garratt, C. J., & Holden, A. V. (2004). Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation. In A. Murray (Ed.), Computers in Cardiology 2004 (Vol. 31, pp. 141-144). Piscataway, NJ: IEEE . DOI: 10.1109/CIC.2004.1442891

Zhang, H.; Zhu, Jiujiang; Garratt, C. J.; Holden, A. V. / Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation.

Computers in Cardiology 2004. ed. / Alan Murray. Vol. 31 Piscataway, NJ : IEEE , 2004. p. 141-144.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

@inbook{15812f2ac9514fb1ad87cabb07a20877,
title = "Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation",
abstract = "Chronic atrial fibrillation (AF) induces remodelling of both channel conductance and intercellular coupling in the human atrium. Effects of these changes and their relative contributions to atrial impulse conduction during fibrillation are unknown. In this study we constructed a virtual human atrial strand by incorporating the Nygren et al model of human atrial action potential into a 1-dimensional reaction diffusion partial differential equation. Experimental data on AF-induced changes of human atrial ionic channel conductances and kinetics and gap junction coupling were incorporated into a model to investigate their contributions and relative importance on conduction velocity (CV) at different rates. At low rates (stimulus interval SI>270 ms), AF-induced channel or gap junction remodelling reduced CV significantly. At high rates (SI<270 ms), channel remodelling increased CV while gap junction remodelling reduced the CV. When combined, channel and gap junction remodelling reduced CV additively. Spatial heterogeneities in gap junction coupling can produce intermittent conduction block.",
author = "H. Zhang and Jiujiang Zhu and Garratt, {C. J.} and Holden, {A. V.}",
year = "2004",
month = "9",
doi = "10.1109/CIC.2004.1442891",
isbn = "0780389271",
volume = "31",
pages = "141--144",
editor = "Alan Murray",
booktitle = "Computers in Cardiology 2004",
publisher = "IEEE",

}

Zhang, H, Zhu, J, Garratt, CJ & Holden, AV 2004, Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation. in A Murray (ed.), Computers in Cardiology 2004. vol. 31, IEEE , Piscataway, NJ, pp. 141-144, Computing in Cardiology, Chicago, United States, 19-22 September. DOI: 10.1109/CIC.2004.1442891

Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation. / Zhang, H.; Zhu, Jiujiang; Garratt, C. J.; Holden, A. V.

Computers in Cardiology 2004. ed. / Alan Murray. Vol. 31 Piscataway, NJ : IEEE , 2004. p. 141-144.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - CHAP

T1 - Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation

AU - Zhang,H.

AU - Zhu,Jiujiang

AU - Garratt,C. J.

AU - Holden,A. V.

PY - 2004/9

Y1 - 2004/9

N2 - Chronic atrial fibrillation (AF) induces remodelling of both channel conductance and intercellular coupling in the human atrium. Effects of these changes and their relative contributions to atrial impulse conduction during fibrillation are unknown. In this study we constructed a virtual human atrial strand by incorporating the Nygren et al model of human atrial action potential into a 1-dimensional reaction diffusion partial differential equation. Experimental data on AF-induced changes of human atrial ionic channel conductances and kinetics and gap junction coupling were incorporated into a model to investigate their contributions and relative importance on conduction velocity (CV) at different rates. At low rates (stimulus interval SI>270 ms), AF-induced channel or gap junction remodelling reduced CV significantly. At high rates (SI<270 ms), channel remodelling increased CV while gap junction remodelling reduced the CV. When combined, channel and gap junction remodelling reduced CV additively. Spatial heterogeneities in gap junction coupling can produce intermittent conduction block.

AB - Chronic atrial fibrillation (AF) induces remodelling of both channel conductance and intercellular coupling in the human atrium. Effects of these changes and their relative contributions to atrial impulse conduction during fibrillation are unknown. In this study we constructed a virtual human atrial strand by incorporating the Nygren et al model of human atrial action potential into a 1-dimensional reaction diffusion partial differential equation. Experimental data on AF-induced changes of human atrial ionic channel conductances and kinetics and gap junction coupling were incorporated into a model to investigate their contributions and relative importance on conduction velocity (CV) at different rates. At low rates (stimulus interval SI>270 ms), AF-induced channel or gap junction remodelling reduced CV significantly. At high rates (SI<270 ms), channel remodelling increased CV while gap junction remodelling reduced the CV. When combined, channel and gap junction remodelling reduced CV additively. Spatial heterogeneities in gap junction coupling can produce intermittent conduction block.

U2 - 10.1109/CIC.2004.1442891

DO - 10.1109/CIC.2004.1442891

M3 - Conference contribution

SN - 0780389271

VL - 31

SP - 141

EP - 144

BT - Computers in Cardiology 2004

PB - IEEE

ER -

Zhang H, Zhu J, Garratt CJ, Holden AV. Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation. In Murray A, editor, Computers in Cardiology 2004. Vol. 31. Piscataway, NJ: IEEE . 2004. p. 141-144. Available from, DOI: 10.1109/CIC.2004.1442891