Abstract
| Original language | English |
|---|---|
| Title of host publication | Computers in Cardiology 2004 |
| Editors | Alan Murray |
| Place of Publication | Piscataway, NJ |
| Publisher | IEEE |
| Pages | 141-144 |
| Number of pages | 4 |
| Volume | 31 |
| ISBN (Print) | 0780389271 |
| DOIs | |
| State | Published - Sep 2004 |
| Event | Computing in Cardiology - Chicago, United States |
Conference
| Conference | Computing in Cardiology |
|---|---|
| Abbreviated title | CinC |
| Country | United States |
| City | Chicago |
| Period | 19/09/04 → 22/09/04 |
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Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation. / Zhang, H.; Zhu, Jiujiang; Garratt, C. J.; Holden, A. V.
Computers in Cardiology 2004. ed. / Alan Murray. Vol. 31 Piscataway, NJ : IEEE , 2004. p. 141-144.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - CHAP
T1 - Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation
AU - Zhang,H.
AU - Zhu,Jiujiang
AU - Garratt,C. J.
AU - Holden,A. V.
PY - 2004/9
Y1 - 2004/9
N2 - Chronic atrial fibrillation (AF) induces remodelling of both channel conductance and intercellular coupling in the human atrium. Effects of these changes and their relative contributions to atrial impulse conduction during fibrillation are unknown. In this study we constructed a virtual human atrial strand by incorporating the Nygren et al model of human atrial action potential into a 1-dimensional reaction diffusion partial differential equation. Experimental data on AF-induced changes of human atrial ionic channel conductances and kinetics and gap junction coupling were incorporated into a model to investigate their contributions and relative importance on conduction velocity (CV) at different rates. At low rates (stimulus interval SI>270 ms), AF-induced channel or gap junction remodelling reduced CV significantly. At high rates (SI<270 ms), channel remodelling increased CV while gap junction remodelling reduced the CV. When combined, channel and gap junction remodelling reduced CV additively. Spatial heterogeneities in gap junction coupling can produce intermittent conduction block.
AB - Chronic atrial fibrillation (AF) induces remodelling of both channel conductance and intercellular coupling in the human atrium. Effects of these changes and their relative contributions to atrial impulse conduction during fibrillation are unknown. In this study we constructed a virtual human atrial strand by incorporating the Nygren et al model of human atrial action potential into a 1-dimensional reaction diffusion partial differential equation. Experimental data on AF-induced changes of human atrial ionic channel conductances and kinetics and gap junction coupling were incorporated into a model to investigate their contributions and relative importance on conduction velocity (CV) at different rates. At low rates (stimulus interval SI>270 ms), AF-induced channel or gap junction remodelling reduced CV significantly. At high rates (SI<270 ms), channel remodelling increased CV while gap junction remodelling reduced the CV. When combined, channel and gap junction remodelling reduced CV additively. Spatial heterogeneities in gap junction coupling can produce intermittent conduction block.
U2 - 10.1109/CIC.2004.1442891
DO - 10.1109/CIC.2004.1442891
M3 - Conference contribution
SN - 0780389271
VL - 31
SP - 141
EP - 144
BT - Computers in Cardiology 2004
PB - IEEE
ER -