Abstract
| Original language | English |
|---|---|
| Pages (from-to) | E764-E770 |
| Number of pages | 7 |
| Journal | AJP Endocrinology & Metabolism |
| Volume | 284 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2003 |
| Externally published | Yes |
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Creatine supplementation has no effect on human muscle protein turnover at rest in the postabsorptive or fed states. / Louis, Magali; Poortmans, Jacques R.; Francaux, Marc; Hultman, Eric ; Berré, Jacques; Boisseau, Nathalie; Young, Vernon R.; Smith, Kenneth; Meier-Augenstein, Wolfram; Babraj, John A.; Waddell, Tom; Rennie, Michael J.
In: AJP Endocrinology & Metabolism, Vol. 284, No. 4, 04.2003, p. E764-E770.Research output: Contribution to journal › Article
TY - JOUR
T1 - Creatine supplementation has no effect on human muscle protein turnover at rest in the postabsorptive or fed states
AU - Louis, Magali
AU - Poortmans, Jacques R.
AU - Francaux, Marc
AU - Hultman, Eric
AU - Berré, Jacques
AU - Boisseau, Nathalie
AU - Young, Vernon R.
AU - Smith, Kenneth
AU - Meier-Augenstein, Wolfram
AU - Babraj, John A.
AU - Waddell, Tom
AU - Rennie, Michael J.
PY - 2003/4
Y1 - 2003/4
N2 - Dietary creatine supplementation is associated with increases in muscle mass, but the mechanism is unknown. We tested the hypothesis that creatine supplementation enhanced myofibrillar protein synthesis (MPS) and diminished muscle protein breakdown (MPB) in the fed state. Six healthy men (26 ± 7 yr, body mass index 22 ± 4 kg/m2) were studied twice, 2-4 wk apart, before and after ingestion of creatine (21 g/day, 5 days). We carried out two sets of measurements within 5.5 h of both MPS (by incorporation of [1-13C]leucine in quadriceps muscle) and MPB (as dilution of [1-13C]leucine or [2H5]phenylalanine across the forearm); for the first 3 h, the subjects were postabsorptive but thereafter were fed orally (0.3 g maltodextrin and 0.083 g protein. kg body wt-1 x h-1). Creatine supplementation increased muscle total creatine by approximately 30% (P < 0.01). Feeding had significant effects, doubling MPS (P < 0.001) and depressing MPB by approximately 40% (P < 0.026), but creatine had no effect on turnover in the postabsorptive or fed states. Thus any increase in muscle mass accompanying creatine supplementation must be associated with increased physical activity.
AB - Dietary creatine supplementation is associated with increases in muscle mass, but the mechanism is unknown. We tested the hypothesis that creatine supplementation enhanced myofibrillar protein synthesis (MPS) and diminished muscle protein breakdown (MPB) in the fed state. Six healthy men (26 ± 7 yr, body mass index 22 ± 4 kg/m2) were studied twice, 2-4 wk apart, before and after ingestion of creatine (21 g/day, 5 days). We carried out two sets of measurements within 5.5 h of both MPS (by incorporation of [1-13C]leucine in quadriceps muscle) and MPB (as dilution of [1-13C]leucine or [2H5]phenylalanine across the forearm); for the first 3 h, the subjects were postabsorptive but thereafter were fed orally (0.3 g maltodextrin and 0.083 g protein. kg body wt-1 x h-1). Creatine supplementation increased muscle total creatine by approximately 30% (P < 0.01). Feeding had significant effects, doubling MPS (P < 0.001) and depressing MPB by approximately 40% (P < 0.026), but creatine had no effect on turnover in the postabsorptive or fed states. Thus any increase in muscle mass accompanying creatine supplementation must be associated with increased physical activity.
U2 - 10.1152/ajpendo.00338.2002
DO - 10.1152/ajpendo.00338.2002
M3 - Article
VL - 284
SP - E764-E770
JO - AJP Endocrinology & Metabolism
JF - AJP Endocrinology & Metabolism
IS - 4
ER -