Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part II. In vivo studies

Kristin Uth, Roger Sleigh

    Research output: Contribution to journalArticle

    8 Citations (Scopus)
    27 Downloads (Pure)

    Abstract

    The uneventful progression through the cell cycle is closely associated with the rhythm set by the circadian clock machinery, with the S-phase of the cell cycle typically occurring at night. Presence of unrepaired DNA damage may reset the phase of the circadian clock, providing opportunities for damage assessment, repair and/or the induction of pro-apoptotic pathways. The core proteins of the circadian clock regulate directly or indirectly a significant number of genes coding for proteins involved in checkpoint transition, cell proliferation and programmed cell death. Disruption of the circadian rhythm may increase the risk for some multifactorial diseases and conditions, including glucose intolerance, cardiovascular disease and various common cancers. In patients with cancer, chronic circadian misalignment may stimulate the growth of tumours and may modify the outcomes of anticancer therapy. Knowledge about the role of physiological rhythms in human disease may contribute to the field of individualized medicine, specifically, in risk assessment and prognostication of the outcomes in patients with multifactorial disease.
    Original languageEnglish
    Pages (from-to)379-386
    Number of pages8
    JournalBiotechnology & Biotechnological Equipment
    Volume28
    Issue number3
    Early online date24 Jul 2014
    DOIs
    Publication statusPublished - 2014

    Fingerprint

    Circadian Clocks
    Carcinogenesis
    Cell Cycle
    Neoplasms
    Precision Medicine
    Glucose Intolerance
    Circadian Rhythm
    S Phase
    DNA Damage
    Proteins
    Cell Death
    Cardiovascular Diseases
    Cell Proliferation
    Growth
    Therapeutics

    Cite this

    @article{ec3a8d2640da41b8a34166ffe44b70cd,
    title = "Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part II. In vivo studies",
    abstract = "The uneventful progression through the cell cycle is closely associated with the rhythm set by the circadian clock machinery, with the S-phase of the cell cycle typically occurring at night. Presence of unrepaired DNA damage may reset the phase of the circadian clock, providing opportunities for damage assessment, repair and/or the induction of pro-apoptotic pathways. The core proteins of the circadian clock regulate directly or indirectly a significant number of genes coding for proteins involved in checkpoint transition, cell proliferation and programmed cell death. Disruption of the circadian rhythm may increase the risk for some multifactorial diseases and conditions, including glucose intolerance, cardiovascular disease and various common cancers. In patients with cancer, chronic circadian misalignment may stimulate the growth of tumours and may modify the outcomes of anticancer therapy. Knowledge about the role of physiological rhythms in human disease may contribute to the field of individualized medicine, specifically, in risk assessment and prognostication of the outcomes in patients with multifactorial disease.",
    author = "Kristin Uth and Roger Sleigh",
    year = "2014",
    doi = "10.1080/13102818.2014.925298",
    language = "English",
    volume = "28",
    pages = "379--386",
    journal = "Biotechnology and Biotechnological Equipment",
    issn = "1310-2818",
    publisher = "TAYLOR & FRANCIS LTD",
    number = "3",

    }

    Deregulation of the circadian clock constitutes a significant factor in tumorigenesis : a clockwork cancer. Part II. In vivo studies. / Uth, Kristin; Sleigh, Roger.

    In: Biotechnology & Biotechnological Equipment, Vol. 28, No. 3, 2014, p. 379-386.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Deregulation of the circadian clock constitutes a significant factor in tumorigenesis

    T2 - a clockwork cancer. Part II. In vivo studies

    AU - Uth, Kristin

    AU - Sleigh, Roger

    PY - 2014

    Y1 - 2014

    N2 - The uneventful progression through the cell cycle is closely associated with the rhythm set by the circadian clock machinery, with the S-phase of the cell cycle typically occurring at night. Presence of unrepaired DNA damage may reset the phase of the circadian clock, providing opportunities for damage assessment, repair and/or the induction of pro-apoptotic pathways. The core proteins of the circadian clock regulate directly or indirectly a significant number of genes coding for proteins involved in checkpoint transition, cell proliferation and programmed cell death. Disruption of the circadian rhythm may increase the risk for some multifactorial diseases and conditions, including glucose intolerance, cardiovascular disease and various common cancers. In patients with cancer, chronic circadian misalignment may stimulate the growth of tumours and may modify the outcomes of anticancer therapy. Knowledge about the role of physiological rhythms in human disease may contribute to the field of individualized medicine, specifically, in risk assessment and prognostication of the outcomes in patients with multifactorial disease.

    AB - The uneventful progression through the cell cycle is closely associated with the rhythm set by the circadian clock machinery, with the S-phase of the cell cycle typically occurring at night. Presence of unrepaired DNA damage may reset the phase of the circadian clock, providing opportunities for damage assessment, repair and/or the induction of pro-apoptotic pathways. The core proteins of the circadian clock regulate directly or indirectly a significant number of genes coding for proteins involved in checkpoint transition, cell proliferation and programmed cell death. Disruption of the circadian rhythm may increase the risk for some multifactorial diseases and conditions, including glucose intolerance, cardiovascular disease and various common cancers. In patients with cancer, chronic circadian misalignment may stimulate the growth of tumours and may modify the outcomes of anticancer therapy. Knowledge about the role of physiological rhythms in human disease may contribute to the field of individualized medicine, specifically, in risk assessment and prognostication of the outcomes in patients with multifactorial disease.

    U2 - 10.1080/13102818.2014.925298

    DO - 10.1080/13102818.2014.925298

    M3 - Article

    VL - 28

    SP - 379

    EP - 386

    JO - Biotechnology and Biotechnological Equipment

    JF - Biotechnology and Biotechnological Equipment

    SN - 1310-2818

    IS - 3

    ER -