DRASTIC—INSIGHTS: querying information in a plant gene expression database

Davina K. Button, Kevan M. A. Gartland, Leslie D. Ball, Louis Natanson, Jill S. Gartland, Gary D. Lyon

Research output: Contribution to journalArticle

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Abstract

DRASTIC––Database Resource for the Analysis of Signal Transduction In Cells (http://www.drastic.org.uk/) has been created as a first step towards a data-based approach for constructing signal transduction pathways. DRASTIC is a relational database of plant expressed sequence tags and genes up- or down-regulated in response to various pathogens, chemical exposure or other treatments such as drought, salt and low temperature. More than 17700 records have been obtained from 306 treatments affecting 73 plant species from 512 peer-reviewed publications with most emphasis being placed on data from Arabidopsis thaliana. DRASTIC has been developed by the Scottish Crop Research Institute and the Abertay University and allows rapid identification of plant genes that are up- or down-regulated by multiple treatments and those that are regulated by a very limited (or perhaps a single) treatment. The INSIGHTS (INference of cell SIGnaling HypoTheseS) suite of web-based tools allows intelligent data mining and extraction of information from the DRASTIC database. Potential response pathways can be visualized and comparisons made between gene expression patterns in response to various treatments. The knowledge gained informs plant signalling pathways and systems biology investigations.
Original languageEnglish
Pages (from-to)D712-D716
Number of pages5
JournalNucleic Acids Research
Volume34
Issue numberSuppl 1
DOIs
StatePublished - Jan 2006

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cells
signal transduction
gene expression
genes
peers
expressed sequence tags
Arabidopsis thaliana
drought
salts
Biological Sciences
pathogens
crops
temperature
plant identification

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Button, D. K., Gartland, K. M. A., Ball, L. D., Natanson, L., Gartland, J. S., & Lyon, G. D. (2006). DRASTIC—INSIGHTS: querying information in a plant gene expression database. Nucleic Acids Research, 34(Suppl 1), D712-D716. DOI: 10.1093/nar/gkj136

Button, Davina K.; Gartland, Kevan M. A.; Ball, Leslie D.; Natanson, Louis; Gartland, Jill S.; Lyon, Gary D. / DRASTIC—INSIGHTS : querying information in a plant gene expression database.

In: Nucleic Acids Research, Vol. 34, No. Suppl 1, 01.2006, p. D712-D716.

Research output: Contribution to journalArticle

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abstract = "DRASTIC––Database Resource for the Analysis of Signal Transduction In Cells (http://www.drastic.org.uk/) has been created as a first step towards a data-based approach for constructing signal transduction pathways. DRASTIC is a relational database of plant expressed sequence tags and genes up- or down-regulated in response to various pathogens, chemical exposure or other treatments such as drought, salt and low temperature. More than 17700 records have been obtained from 306 treatments affecting 73 plant species from 512 peer-reviewed publications with most emphasis being placed on data from Arabidopsis thaliana. DRASTIC has been developed by the Scottish Crop Research Institute and the Abertay University and allows rapid identification of plant genes that are up- or down-regulated by multiple treatments and those that are regulated by a very limited (or perhaps a single) treatment. The INSIGHTS (INference of cell SIGnaling HypoTheseS) suite of web-based tools allows intelligent data mining and extraction of information from the DRASTIC database. Potential response pathways can be visualized and comparisons made between gene expression patterns in response to various treatments. The knowledge gained informs plant signalling pathways and systems biology investigations.",
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Button, DK, Gartland, KMA, Ball, LD, Natanson, L, Gartland, JS & Lyon, GD 2006, 'DRASTIC—INSIGHTS: querying information in a plant gene expression database' Nucleic Acids Research, vol 34, no. Suppl 1, pp. D712-D716. DOI: 10.1093/nar/gkj136

DRASTIC—INSIGHTS : querying information in a plant gene expression database. / Button, Davina K.; Gartland, Kevan M. A.; Ball, Leslie D.; Natanson, Louis; Gartland, Jill S.; Lyon, Gary D.

In: Nucleic Acids Research, Vol. 34, No. Suppl 1, 01.2006, p. D712-D716.

Research output: Contribution to journalArticle

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T2 - Nucleic Acids Research

AU - Button,Davina K.

AU - Gartland,Kevan M. A.

AU - Ball,Leslie D.

AU - Natanson,Louis

AU - Gartland,Jill S.

AU - Lyon,Gary D.

PY - 2006/1

Y1 - 2006/1

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AB - DRASTIC––Database Resource for the Analysis of Signal Transduction In Cells (http://www.drastic.org.uk/) has been created as a first step towards a data-based approach for constructing signal transduction pathways. DRASTIC is a relational database of plant expressed sequence tags and genes up- or down-regulated in response to various pathogens, chemical exposure or other treatments such as drought, salt and low temperature. More than 17700 records have been obtained from 306 treatments affecting 73 plant species from 512 peer-reviewed publications with most emphasis being placed on data from Arabidopsis thaliana. DRASTIC has been developed by the Scottish Crop Research Institute and the Abertay University and allows rapid identification of plant genes that are up- or down-regulated by multiple treatments and those that are regulated by a very limited (or perhaps a single) treatment. The INSIGHTS (INference of cell SIGnaling HypoTheseS) suite of web-based tools allows intelligent data mining and extraction of information from the DRASTIC database. Potential response pathways can be visualized and comparisons made between gene expression patterns in response to various treatments. The knowledge gained informs plant signalling pathways and systems biology investigations.

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Button DK, Gartland KMA, Ball LD, Natanson L, Gartland JS, Lyon GD. DRASTIC—INSIGHTS: querying information in a plant gene expression database. Nucleic Acids Research. 2006 Jan;34(Suppl 1):D712-D716. Available from, DOI: 10.1093/nar/gkj136