Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts

A. R. Gizatullin, N. P. Akentieva*, N. A. Sanina, N. Yu. Shmatko, N. S. Goryachev, N. I. Shkondina, T. R. Prichodchenko, N. Zhelev, S. M. Aldoshin

*Corresponding author for this work

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    Abstract

    The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

    Original languageEnglish
    Pages (from-to)337-340
    Number of pages4
    JournalDoklady Biochemistry and Biophysics
    Volume483
    Issue number1
    Early online date3 Jan 2019
    DOIs
    Publication statusPublished - 3 Jan 2019

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    Gizatullin, A. R., Akentieva, N. P., Sanina, N. A., Shmatko, N. Y., Goryachev, N. S., Shkondina, N. I., ... Aldoshin, S. M. (2019). Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts. Doklady Biochemistry and Biophysics, 483(1), 337-340. https://doi.org/10.1134/S1607672918060133