Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts

A. R. Gizatullin, N. P. Akentieva*, N. A. Sanina, N. Yu. Shmatko, N. S. Goryachev, N. I. Shkondina, T. R. Prichodchenko, N. Zhelev, S. M. Aldoshin

*Corresponding author for this work

    Research output: Contribution to journalArticle

    Abstract

    The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

    Original languageEnglish
    Pages (from-to)337-340
    Number of pages4
    JournalDoklady Biochemistry and Biophysics
    Volume483
    Issue number1
    Early online date3 Jan 2019
    DOIs
    Publication statusPublished - 3 Jan 2019

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    Fibroblasts
    Cell Survival
    Cells
    Iron Compounds
    Mitochondrial Membrane Potential
    Sulfur
    Metabolism
    Glutathione
    Reactive Oxygen Species
    Cardiovascular Diseases
    Ligands
    Membranes
    Lung
    dinitrosyl iron complex
    Therapeutics

    Cite this

    Gizatullin, A. R., Akentieva, N. P., Sanina, N. A., Shmatko, N. Y., Goryachev, N. S., Shkondina, N. I., ... Aldoshin, S. M. (2019). Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts. Doklady Biochemistry and Biophysics, 483(1), 337-340. https://doi.org/10.1134/S1607672918060133
    Gizatullin, A. R. ; Akentieva, N. P. ; Sanina, N. A. ; Shmatko, N. Yu. ; Goryachev, N. S. ; Shkondina, N. I. ; Prichodchenko, T. R. ; Zhelev, N. ; Aldoshin, S. M. / Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts. In: Doklady Biochemistry and Biophysics. 2019 ; Vol. 483, No. 1. pp. 337-340.
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    abstract = "The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.",
    author = "Gizatullin, {A. R.} and Akentieva, {N. P.} and Sanina, {N. A.} and Shmatko, {N. Yu.} and Goryachev, {N. S.} and Shkondina, {N. I.} and Prichodchenko, {T. R.} and N. Zhelev and Aldoshin, {S. M.}",
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    Gizatullin, AR, Akentieva, NP, Sanina, NA, Shmatko, NY, Goryachev, NS, Shkondina, NI, Prichodchenko, TR, Zhelev, N & Aldoshin, SM 2019, 'Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts', Doklady Biochemistry and Biophysics, vol. 483, no. 1, pp. 337-340. https://doi.org/10.1134/S1607672918060133

    Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts. / Gizatullin, A. R.; Akentieva, N. P.; Sanina, N. A.; Shmatko, N. Yu.; Goryachev, N. S.; Shkondina, N. I.; Prichodchenko, T. R.; Zhelev, N.; Aldoshin, S. M.

    In: Doklady Biochemistry and Biophysics, Vol. 483, No. 1, 03.01.2019, p. 337-340.

    Research output: Contribution to journalArticle

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    AU - Akentieva, N. P.

    AU - Sanina, N. A.

    AU - Shmatko, N. Yu.

    AU - Goryachev, N. S.

    AU - Shkondina, N. I.

    AU - Prichodchenko, T. R.

    AU - Zhelev, N.

    AU - Aldoshin, S. M.

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    AB - The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

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    Gizatullin AR, Akentieva NP, Sanina NA, Shmatko NY, Goryachev NS, Shkondina NI et al. Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts. Doklady Biochemistry and Biophysics. 2019 Jan 3;483(1):337-340. https://doi.org/10.1134/S1607672918060133