Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts

A. R. Gizatullin; N. P. Akentieva; N. A. Sanina; N. Yu. Shmatko; N. S. Goryachev; N. I. Shkondina; T. R. Prichodchenko; N. Zhelev; S. M. Aldoshin

doi:10.1134/S1607672918060133

Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts

A. R. Gizatullin
, N. P. Akentieva^*
, N. A. Sanina
, N. Yu. Shmatko
, N. S. Goryachev
, N. I. Shkondina
, T. R. Prichodchenko
, N. Zhelev
, S. M. Aldoshin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

Original language	English
Pages (from-to)	337-340
Number of pages	4
Journal	Doklady Biochemistry and Biophysics
Volume	483
Issue number	1
Early online date	3 Jan 2019
DOIs	https://doi.org/10.1134/S1607672918060133
Publication status	Published - 3 Jan 2019

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title = "Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts",

abstract = "The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.",

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T1 - Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts

AU - Gizatullin, A. R.

AU - Akentieva, N. P.

AU - Sanina, N. A.

AU - Shmatko, N. Yu.

AU - Goryachev, N. S.

AU - Shkondina, N. I.

AU - Prichodchenko, T. R.

AU - Zhelev, N.

AU - Aldoshin, S. M.

PY - 2019/1/3

Y1 - 2019/1/3

N2 - The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

AB - The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

U2 - 10.1134/S1607672918060133

DO - 10.1134/S1607672918060133

M3 - Article

AN - SCOPUS:85059471970

SN - 1607-6729

VL - 483

SP - 337

EP - 340

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

IS - 1

ER -

Effect of dinitrosyl iron complexes (NO donors) on the metabolic processes in human fibroblasts

Abstract

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