Effect of vitamin K on vascular health and physical function in older people with vascular disease: a randomised controlled trial

R L Fulton, M. E. T. McMurdo, A Hill, R. J. Abboud, G. P. Arnold, A. D. Struthers, F. Khan, C. Vermeer, M. H. J. Knapen, N. E. A. Drummen, M. D. Witham

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Abstract

BACKGROUND AND AIMS: Vitamin K insufficiency is common and linked to an increased risk of cardiovascular disease and osteoporotic fractures. The aim of this study was to examine whether daily supplementation with oral vitamin K could improve vascular health and physical function in older people with established vascular disease.

METHODS AND RESULTS: A double blind, randomised, placebo-controlled trial. Participants aged ≤ 70 years with a history of vascular disease were randomised to receive 6 months of daily oral 100mcg vitamin K2 (MK7 subtype) or matching placebo with outcomes measured at 0, 3 and 6 months. The primary outcome was between-group difference in endothelial function assessed using flow-mediated dilatation of the brachial artery at 6 months. Secondary outcomes included carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type natriuretic peptide, cholesterol and desphospho-uncarboxylated matrix Gla protein levels. Handgrip strength and the Short Physical Performance Battery assessed physical function, while postural sway was measured using a 3-dimensional force platform.

RESULTS: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 were male. Vitamin K levels rose in the intervention arm compared to placebo (+48 pg/ml vs -6 pg/ml, p=0.03) at 6 months. Desphospho-uncarboxylated Matrix Gla protein levels fell in the intervention group compared to placebo at 6 months (-130 [SD 117] pmol/L vs +13 [SD 180] pmol/L, p<0.001). No change was seen in endothelial function (between group difference -0.3% [95%CI -1.3 to 0.8], p=0.62). A modest, non-significant improvement in pulse wave velocity was seen in the vitamin K group (-0.8m/s [95%CI -1.8 to 0.3], p=0.15) while all other vascular and physical function outcomes unchanged.

CONCLUSIONS: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.

Original languageEnglish
Pages (from-to)325-33
Number of pages9
JournalJournal of Nutrition, Health and Aging
Volume20
Issue number3
Early online date14 Nov 2015
DOIs
Publication statusPublished - Mar 2016
Externally publishedYes

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Vitamin K
Vascular Diseases
Blood Vessels
Randomized Controlled Trials
Placebos
Vitamin K 2
Pulse Wave Analysis
Health
Carotid Intima-Media Thickness
Osteoporotic Fractures
Brachial Artery
Brain Natriuretic Peptide
C-Reactive Protein
Dilatation
Cardiovascular Diseases
Cholesterol
Blood Pressure
matrix Gla protein

Cite this

Fulton, R L ; McMurdo, M. E. T. ; Hill, A ; Abboud, R. J. ; Arnold, G. P. ; Struthers, A. D. ; Khan, F. ; Vermeer, C. ; Knapen, M. H. J. ; Drummen, N. E. A. ; Witham, M. D. / Effect of vitamin K on vascular health and physical function in older people with vascular disease : a randomised controlled trial. In: Journal of Nutrition, Health and Aging. 2016 ; Vol. 20, No. 3. pp. 325-33.
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title = "Effect of vitamin K on vascular health and physical function in older people with vascular disease: a randomised controlled trial",
abstract = "BACKGROUND AND AIMS: Vitamin K insufficiency is common and linked to an increased risk of cardiovascular disease and osteoporotic fractures. The aim of this study was to examine whether daily supplementation with oral vitamin K could improve vascular health and physical function in older people with established vascular disease.METHODS AND RESULTS: A double blind, randomised, placebo-controlled trial. Participants aged ≤ 70 years with a history of vascular disease were randomised to receive 6 months of daily oral 100mcg vitamin K2 (MK7 subtype) or matching placebo with outcomes measured at 0, 3 and 6 months. The primary outcome was between-group difference in endothelial function assessed using flow-mediated dilatation of the brachial artery at 6 months. Secondary outcomes included carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type natriuretic peptide, cholesterol and desphospho-uncarboxylated matrix Gla protein levels. Handgrip strength and the Short Physical Performance Battery assessed physical function, while postural sway was measured using a 3-dimensional force platform.RESULTS: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 were male. Vitamin K levels rose in the intervention arm compared to placebo (+48 pg/ml vs -6 pg/ml, p=0.03) at 6 months. Desphospho-uncarboxylated Matrix Gla protein levels fell in the intervention group compared to placebo at 6 months (-130 [SD 117] pmol/L vs +13 [SD 180] pmol/L, p<0.001). No change was seen in endothelial function (between group difference -0.3{\%} [95{\%}CI -1.3 to 0.8], p=0.62). A modest, non-significant improvement in pulse wave velocity was seen in the vitamin K group (-0.8m/s [95{\%}CI -1.8 to 0.3], p=0.15) while all other vascular and physical function outcomes unchanged.CONCLUSIONS: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.",
author = "Fulton, {R L} and McMurdo, {M. E. T.} and A Hill and Abboud, {R. J.} and Arnold, {G. P.} and Struthers, {A. D.} and F. Khan and C. Vermeer and Knapen, {M. H. J.} and Drummen, {N. E. A.} and Witham, {M. D.}",
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Fulton, RL, McMurdo, MET, Hill, A, Abboud, RJ, Arnold, GP, Struthers, AD, Khan, F, Vermeer, C, Knapen, MHJ, Drummen, NEA & Witham, MD 2016, 'Effect of vitamin K on vascular health and physical function in older people with vascular disease: a randomised controlled trial', Journal of Nutrition, Health and Aging, vol. 20, no. 3, pp. 325-33. https://doi.org/10.1007/s12603-015-0619-4

Effect of vitamin K on vascular health and physical function in older people with vascular disease : a randomised controlled trial. / Fulton, R L; McMurdo, M. E. T.; Hill, A; Abboud, R. J.; Arnold, G. P.; Struthers, A. D.; Khan, F.; Vermeer, C.; Knapen, M. H. J.; Drummen, N. E. A.; Witham, M. D.

In: Journal of Nutrition, Health and Aging, Vol. 20, No. 3, 03.2016, p. 325-33.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of vitamin K on vascular health and physical function in older people with vascular disease

T2 - a randomised controlled trial

AU - Fulton, R L

AU - McMurdo, M. E. T.

AU - Hill, A

AU - Abboud, R. J.

AU - Arnold, G. P.

AU - Struthers, A. D.

AU - Khan, F.

AU - Vermeer, C.

AU - Knapen, M. H. J.

AU - Drummen, N. E. A.

AU - Witham, M. D.

PY - 2016/3

Y1 - 2016/3

N2 - BACKGROUND AND AIMS: Vitamin K insufficiency is common and linked to an increased risk of cardiovascular disease and osteoporotic fractures. The aim of this study was to examine whether daily supplementation with oral vitamin K could improve vascular health and physical function in older people with established vascular disease.METHODS AND RESULTS: A double blind, randomised, placebo-controlled trial. Participants aged ≤ 70 years with a history of vascular disease were randomised to receive 6 months of daily oral 100mcg vitamin K2 (MK7 subtype) or matching placebo with outcomes measured at 0, 3 and 6 months. The primary outcome was between-group difference in endothelial function assessed using flow-mediated dilatation of the brachial artery at 6 months. Secondary outcomes included carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type natriuretic peptide, cholesterol and desphospho-uncarboxylated matrix Gla protein levels. Handgrip strength and the Short Physical Performance Battery assessed physical function, while postural sway was measured using a 3-dimensional force platform.RESULTS: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 were male. Vitamin K levels rose in the intervention arm compared to placebo (+48 pg/ml vs -6 pg/ml, p=0.03) at 6 months. Desphospho-uncarboxylated Matrix Gla protein levels fell in the intervention group compared to placebo at 6 months (-130 [SD 117] pmol/L vs +13 [SD 180] pmol/L, p<0.001). No change was seen in endothelial function (between group difference -0.3% [95%CI -1.3 to 0.8], p=0.62). A modest, non-significant improvement in pulse wave velocity was seen in the vitamin K group (-0.8m/s [95%CI -1.8 to 0.3], p=0.15) while all other vascular and physical function outcomes unchanged.CONCLUSIONS: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.

AB - BACKGROUND AND AIMS: Vitamin K insufficiency is common and linked to an increased risk of cardiovascular disease and osteoporotic fractures. The aim of this study was to examine whether daily supplementation with oral vitamin K could improve vascular health and physical function in older people with established vascular disease.METHODS AND RESULTS: A double blind, randomised, placebo-controlled trial. Participants aged ≤ 70 years with a history of vascular disease were randomised to receive 6 months of daily oral 100mcg vitamin K2 (MK7 subtype) or matching placebo with outcomes measured at 0, 3 and 6 months. The primary outcome was between-group difference in endothelial function assessed using flow-mediated dilatation of the brachial artery at 6 months. Secondary outcomes included carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type natriuretic peptide, cholesterol and desphospho-uncarboxylated matrix Gla protein levels. Handgrip strength and the Short Physical Performance Battery assessed physical function, while postural sway was measured using a 3-dimensional force platform.RESULTS: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 were male. Vitamin K levels rose in the intervention arm compared to placebo (+48 pg/ml vs -6 pg/ml, p=0.03) at 6 months. Desphospho-uncarboxylated Matrix Gla protein levels fell in the intervention group compared to placebo at 6 months (-130 [SD 117] pmol/L vs +13 [SD 180] pmol/L, p<0.001). No change was seen in endothelial function (between group difference -0.3% [95%CI -1.3 to 0.8], p=0.62). A modest, non-significant improvement in pulse wave velocity was seen in the vitamin K group (-0.8m/s [95%CI -1.8 to 0.3], p=0.15) while all other vascular and physical function outcomes unchanged.CONCLUSIONS: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.

U2 - 10.1007/s12603-015-0619-4

DO - 10.1007/s12603-015-0619-4

M3 - Article

C2 - 26892582

VL - 20

SP - 325

EP - 333

JO - Journal of Nutrition, Health and Aging

JF - Journal of Nutrition, Health and Aging

SN - 1279-7707

IS - 3

ER -