Effect of vitamin K2 on postural sway in older people who fall: a randomized controlled trial

Miles D Witham; Rosemary J G Price; Margaret M Band; Michael S Hannah; Roberta L Fulton; Clare L Clarke; Peter T Donnan; Paul McNamee; Vera Cvoro; Roy L Soiza

doi:10.1111/jgs.16024

Effect of vitamin K2 on postural sway in older people who fall: a randomized controlled trial

Miles D Witham, Rosemary J G Price, Margaret M Band, Michael S Hannah, Roberta L Fulton, Clare L Clarke, Peter T Donnan, Paul McNamee, Vera Cvoro, Roy L Soiza

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Abstract

OBJECTIVES: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls.

DESIGN: Parallel-group double-blind randomized placebo-controlled trial.

SETTING: Fourteen primary care practices in Scotland, UK.

PARTICIPANTS: A total of 95 community-dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year.

INTERVENTION: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year.

MEASUREMENTS: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events.

RESULTS: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12-month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: -.19 cm [95% confidence interval [CI] -.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI -.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI -.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm.

CONCLUSION: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls.

Original language	English
Pages (from-to)	2102-2107
Number of pages	6
Journal	Journal of the American Geriatrics Society
Volume	67
Issue number	10
Early online date	18 Jun 2019
DOIs	https://doi.org/10.1111/jgs.16024
Publication status	Published - 15 Oct 2019

Keywords

Falls
Vitamin K
Postural sway
Health economic analysis
Recruitment

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Fulton_Effect-of Vitamin-K2_Publsihed_2019Final published version, 202 KBLicence: CC BY-NC

Cite this

@article{e041f86cd26e46b49d069ca419338635,

title = "Effect of vitamin K2 on postural sway in older people who fall: a randomized controlled trial",

abstract = "OBJECTIVES: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls.DESIGN: Parallel-group double-blind randomized placebo-controlled trial.SETTING: Fourteen primary care practices in Scotland, UK.PARTICIPANTS: A total of 95 community-dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year.INTERVENTION: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year.MEASUREMENTS: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up \& Go Test, quality of life, health and social care costs, falls, and adverse events.RESULTS: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61\%) were female; 77 of 95 (81\%) attended the 12-month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: -.19 cm [95\% confidence interval [CI] -.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95\% CI -.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95\% CI -.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm.CONCLUSION: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls.",

author = "Witham, \{Miles D\} and Price, \{Rosemary J G\} and Band, \{Margaret M\} and Hannah, \{Michael S\} and Fulton, \{Roberta L\} and Clarke, \{Clare L\} and Donnan, \{Peter T\} and Paul McNamee and Vera Cvoro and Soiza, \{Roy L\}",

year = "2019",

month = oct,

day = "15",

doi = "10.1111/jgs.16024",

language = "English",

volume = "67",

pages = "2102--2107",

journal = "Journal of the American Geriatrics Society",

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number = "10",

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TY - JOUR

T1 - Effect of vitamin K2 on postural sway in older people who fall

T2 - a randomized controlled trial

AU - Witham, Miles D

AU - Price, Rosemary J G

AU - Band, Margaret M

AU - Hannah, Michael S

AU - Fulton, Roberta L

AU - Clarke, Clare L

AU - Donnan, Peter T

AU - McNamee, Paul

AU - Cvoro, Vera

AU - Soiza, Roy L

PY - 2019/10/15

Y1 - 2019/10/15

N2 - OBJECTIVES: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls.DESIGN: Parallel-group double-blind randomized placebo-controlled trial.SETTING: Fourteen primary care practices in Scotland, UK.PARTICIPANTS: A total of 95 community-dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year.INTERVENTION: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year.MEASUREMENTS: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events.RESULTS: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12-month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: -.19 cm [95% confidence interval [CI] -.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI -.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI -.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm.CONCLUSION: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls.

AB - OBJECTIVES: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls.DESIGN: Parallel-group double-blind randomized placebo-controlled trial.SETTING: Fourteen primary care practices in Scotland, UK.PARTICIPANTS: A total of 95 community-dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year.INTERVENTION: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year.MEASUREMENTS: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events.RESULTS: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12-month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: -.19 cm [95% confidence interval [CI] -.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI -.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI -.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm.CONCLUSION: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls.

U2 - 10.1111/jgs.16024

DO - 10.1111/jgs.16024

M3 - Article

C2 - 31211416

SN - 0002-8614

VL - 67

SP - 2102

EP - 2107

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

IS - 10

ER -

Effect of vitamin K2 on postural sway in older people who fall: a randomized controlled trial

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