Efficacy and cost of an exercise program for functionally impaired older patients with heart failure: a randomized controlled trial

Miles D. Witham, Roberta L. Fulton, Carol A. Greig, Derek W. Johnston, Chim C. Lang, Marjon van der Pol, Dwayne Boyers, Allan D. Struthers, Marion E. T. McMurdo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

BACKGROUND: Little is known about the optimum way to deliver exercise to older, functionally impaired patients with heart failure. We tested whether an exercise program tailored to the needs of these patients could improve exercise capacity and quality of life or reduce costs to the National Health Service.

METHODS AND RESULTS: The study design was a parallel-group, single-blind, randomized controlled trial. Patients aged ≥70 years with symptomatic heart failure and left ventricular systolic dysfunction were randomized to either 24 weeks of exercise training or usual care. Six-minute walk distance was the primary outcome; markers of physical function, quality of life, health status, and daily activity were measured at baseline and 8 and 24 weeks. Carer strain and healthcare costs were also recorded. A total of 107 participants were randomized (mean age, 80 years; men, 72 [67%]). Six-minute walk distance did not improve compared to that of the control group at 8 weeks (-16.9 m; 95% CI, -41.8 to 7.9 m; P=0.18) or at 24 weeks (-5.3 m; 95% CI, -32.6 to 22.0 m; P=0.70). For secondary outcomes, only the sit-to-stand test improved significantly at 24 weeks (-6.4 s; 95% CI, -12.2 to 0.6 s; P=0.03); there was no difference in change for the Minnesota Living With Heart Failure score (0.1 points; 95% CI, -0.9 to 1.1 points; P=0.83) at 24 weeks. Carer strain did not decrease at 24 weeks (difference, -0.5 points; 95% CI, -8.3 to 7.3 points; P=0.80), and there was no difference in overall healthcare costs.

CONCLUSIONS: This exercise intervention did not improve exercise capacity or quality of life in older patients with heart failure and was not cost saving to the National Health Service. Clinical Trial Registration- URL: http://www.controlled-trials.com. Unique identifier: ISRCTN51615566.

Original languageEnglish
Pages (from-to)209-16
Number of pages8
JournalCirculation: Heart Failure
Volume5
Issue number2
DOIs
Publication statusPublished - 1 Mar 2012
Externally publishedYes

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Randomized Controlled Trials
Heart Failure
Exercise
Costs and Cost Analysis
Quality of Life
National Health Programs
Health Care Costs
Caregivers
Left Ventricular Dysfunction
Health Status
Clinical Trials
Control Groups

Cite this

Witham, M. D., Fulton, R. L., Greig, C. A., Johnston, D. W., Lang, C. C., van der Pol, M., ... McMurdo, M. E. T. (2012). Efficacy and cost of an exercise program for functionally impaired older patients with heart failure: a randomized controlled trial. Circulation: Heart Failure, 5(2), 209-16. https://doi.org/10.1161/CIRCHEARTFAILURE.111.963132
Witham, Miles D. ; Fulton, Roberta L. ; Greig, Carol A. ; Johnston, Derek W. ; Lang, Chim C. ; van der Pol, Marjon ; Boyers, Dwayne ; Struthers, Allan D. ; McMurdo, Marion E. T. / Efficacy and cost of an exercise program for functionally impaired older patients with heart failure : a randomized controlled trial. In: Circulation: Heart Failure. 2012 ; Vol. 5, No. 2. pp. 209-16.
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Witham, MD, Fulton, RL, Greig, CA, Johnston, DW, Lang, CC, van der Pol, M, Boyers, D, Struthers, AD & McMurdo, MET 2012, 'Efficacy and cost of an exercise program for functionally impaired older patients with heart failure: a randomized controlled trial', Circulation: Heart Failure, vol. 5, no. 2, pp. 209-16. https://doi.org/10.1161/CIRCHEARTFAILURE.111.963132

Efficacy and cost of an exercise program for functionally impaired older patients with heart failure : a randomized controlled trial. / Witham, Miles D.; Fulton, Roberta L.; Greig, Carol A.; Johnston, Derek W.; Lang, Chim C.; van der Pol, Marjon; Boyers, Dwayne; Struthers, Allan D.; McMurdo, Marion E. T.

In: Circulation: Heart Failure, Vol. 5, No. 2, 01.03.2012, p. 209-16.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Efficacy and cost of an exercise program for functionally impaired older patients with heart failure

T2 - a randomized controlled trial

AU - Witham, Miles D.

AU - Fulton, Roberta L.

AU - Greig, Carol A.

AU - Johnston, Derek W.

AU - Lang, Chim C.

AU - van der Pol, Marjon

AU - Boyers, Dwayne

AU - Struthers, Allan D.

AU - McMurdo, Marion E. T.

PY - 2012/3/1

Y1 - 2012/3/1

N2 - BACKGROUND: Little is known about the optimum way to deliver exercise to older, functionally impaired patients with heart failure. We tested whether an exercise program tailored to the needs of these patients could improve exercise capacity and quality of life or reduce costs to the National Health Service.METHODS AND RESULTS: The study design was a parallel-group, single-blind, randomized controlled trial. Patients aged ≥70 years with symptomatic heart failure and left ventricular systolic dysfunction were randomized to either 24 weeks of exercise training or usual care. Six-minute walk distance was the primary outcome; markers of physical function, quality of life, health status, and daily activity were measured at baseline and 8 and 24 weeks. Carer strain and healthcare costs were also recorded. A total of 107 participants were randomized (mean age, 80 years; men, 72 [67%]). Six-minute walk distance did not improve compared to that of the control group at 8 weeks (-16.9 m; 95% CI, -41.8 to 7.9 m; P=0.18) or at 24 weeks (-5.3 m; 95% CI, -32.6 to 22.0 m; P=0.70). For secondary outcomes, only the sit-to-stand test improved significantly at 24 weeks (-6.4 s; 95% CI, -12.2 to 0.6 s; P=0.03); there was no difference in change for the Minnesota Living With Heart Failure score (0.1 points; 95% CI, -0.9 to 1.1 points; P=0.83) at 24 weeks. Carer strain did not decrease at 24 weeks (difference, -0.5 points; 95% CI, -8.3 to 7.3 points; P=0.80), and there was no difference in overall healthcare costs.CONCLUSIONS: This exercise intervention did not improve exercise capacity or quality of life in older patients with heart failure and was not cost saving to the National Health Service. Clinical Trial Registration- URL: http://www.controlled-trials.com. Unique identifier: ISRCTN51615566.

AB - BACKGROUND: Little is known about the optimum way to deliver exercise to older, functionally impaired patients with heart failure. We tested whether an exercise program tailored to the needs of these patients could improve exercise capacity and quality of life or reduce costs to the National Health Service.METHODS AND RESULTS: The study design was a parallel-group, single-blind, randomized controlled trial. Patients aged ≥70 years with symptomatic heart failure and left ventricular systolic dysfunction were randomized to either 24 weeks of exercise training or usual care. Six-minute walk distance was the primary outcome; markers of physical function, quality of life, health status, and daily activity were measured at baseline and 8 and 24 weeks. Carer strain and healthcare costs were also recorded. A total of 107 participants were randomized (mean age, 80 years; men, 72 [67%]). Six-minute walk distance did not improve compared to that of the control group at 8 weeks (-16.9 m; 95% CI, -41.8 to 7.9 m; P=0.18) or at 24 weeks (-5.3 m; 95% CI, -32.6 to 22.0 m; P=0.70). For secondary outcomes, only the sit-to-stand test improved significantly at 24 weeks (-6.4 s; 95% CI, -12.2 to 0.6 s; P=0.03); there was no difference in change for the Minnesota Living With Heart Failure score (0.1 points; 95% CI, -0.9 to 1.1 points; P=0.83) at 24 weeks. Carer strain did not decrease at 24 weeks (difference, -0.5 points; 95% CI, -8.3 to 7.3 points; P=0.80), and there was no difference in overall healthcare costs.CONCLUSIONS: This exercise intervention did not improve exercise capacity or quality of life in older patients with heart failure and was not cost saving to the National Health Service. Clinical Trial Registration- URL: http://www.controlled-trials.com. Unique identifier: ISRCTN51615566.

U2 - 10.1161/CIRCHEARTFAILURE.111.963132

DO - 10.1161/CIRCHEARTFAILURE.111.963132

M3 - Article

C2 - 22271753

VL - 5

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EP - 216

JO - Circulation: Heart Failure

JF - Circulation: Heart Failure

SN - 1941-3289

IS - 2

ER -