Evidence based survey of the distribution volume of ethanol: comparison of empirically determined values with anthropometric measures

Peter D. Maskell, A Wayne Jones, Anne Savage, Michael Scott-Ham

    Research output: Contribution to journalArticle

    Abstract

    The Widmark equation is commonly used when blood alcohol calculations are required in forensic and legal medicine, such as in road-traffic cases and alcohol-related deaths. An important biological variable in this connection is the volume of distribution (Vd) of ethanol, which is commonly referred to as the rho-factor. Although a person’s Vd can be determined empirically through controlled drinking experiments, this approach is not very practical in reality. For this reason, a number of anthropometric equations have been developed that utilize sex, age, height and weight to estimate the person’s total body water (TBW) and hence Vd of ethanol. To date, there aren’t any studies that compare Vd derived from anthropometric data with robust values measured empirically. From the literature we compiled information about the Vd of ethanol from drinking studies with 173 Caucasian males and 63 Caucasian females from Western Europe. These empirically derived values of Vd were then compared with estimates derived from various anthropometric equations. In males the Watson, Watson and Batt regression equation involving age, height and weight gave the most accurate results (bias was 0.00 L/Kg) and 95% confidence limits (CI) were ± 0.13 L/Kg. The equation derived by Forrest, which took into consideration a person’s body mass index (BMI), gave the best estimates of Vd for females; mean bias −0.01 L/Kg and 95% CI ± 0.15 L/Kg.
    Original languageEnglish
    Pages (from-to)124-131
    Number of pages8
    JournalForensic Science International
    Volume294
    Early online date13 Nov 2018
    DOIs
    Publication statusPublished - Jan 2019

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    Forensic Medicine
    Ethanol
    Drinking
    Rho Factor
    Alcohols
    Weights and Measures
    Body Water
    Body Mass Index
    Surveys and Questionnaires

    Cite this

    @article{331d75b42034438b8009aa325f67037a,
    title = "Evidence based survey of the distribution volume of ethanol: comparison of empirically determined values with anthropometric measures",
    abstract = "The Widmark equation is commonly used when blood alcohol calculations are required in forensic and legal medicine, such as in road-traffic cases and alcohol-related deaths. An important biological variable in this connection is the volume of distribution (Vd) of ethanol, which is commonly referred to as the rho-factor. Although a person’s Vd can be determined empirically through controlled drinking experiments, this approach is not very practical in reality. For this reason, a number of anthropometric equations have been developed that utilize sex, age, height and weight to estimate the person’s total body water (TBW) and hence Vd of ethanol. To date, there aren’t any studies that compare Vd derived from anthropometric data with robust values measured empirically. From the literature we compiled information about the Vd of ethanol from drinking studies with 173 Caucasian males and 63 Caucasian females from Western Europe. These empirically derived values of Vd were then compared with estimates derived from various anthropometric equations. In males the Watson, Watson and Batt regression equation involving age, height and weight gave the most accurate results (bias was 0.00 L/Kg) and 95{\%} confidence limits (CI) were ± 0.13 L/Kg. The equation derived by Forrest, which took into consideration a person’s body mass index (BMI), gave the best estimates of Vd for females; mean bias −0.01 L/Kg and 95{\%} CI ± 0.15 L/Kg.",
    author = "Maskell, {Peter D.} and Jones, {A Wayne} and Anne Savage and Michael Scott-Ham",
    year = "2019",
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    language = "English",
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    journal = "Forensic Science International",
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    N2 - The Widmark equation is commonly used when blood alcohol calculations are required in forensic and legal medicine, such as in road-traffic cases and alcohol-related deaths. An important biological variable in this connection is the volume of distribution (Vd) of ethanol, which is commonly referred to as the rho-factor. Although a person’s Vd can be determined empirically through controlled drinking experiments, this approach is not very practical in reality. For this reason, a number of anthropometric equations have been developed that utilize sex, age, height and weight to estimate the person’s total body water (TBW) and hence Vd of ethanol. To date, there aren’t any studies that compare Vd derived from anthropometric data with robust values measured empirically. From the literature we compiled information about the Vd of ethanol from drinking studies with 173 Caucasian males and 63 Caucasian females from Western Europe. These empirically derived values of Vd were then compared with estimates derived from various anthropometric equations. In males the Watson, Watson and Batt regression equation involving age, height and weight gave the most accurate results (bias was 0.00 L/Kg) and 95% confidence limits (CI) were ± 0.13 L/Kg. The equation derived by Forrest, which took into consideration a person’s body mass index (BMI), gave the best estimates of Vd for females; mean bias −0.01 L/Kg and 95% CI ± 0.15 L/Kg.

    AB - The Widmark equation is commonly used when blood alcohol calculations are required in forensic and legal medicine, such as in road-traffic cases and alcohol-related deaths. An important biological variable in this connection is the volume of distribution (Vd) of ethanol, which is commonly referred to as the rho-factor. Although a person’s Vd can be determined empirically through controlled drinking experiments, this approach is not very practical in reality. For this reason, a number of anthropometric equations have been developed that utilize sex, age, height and weight to estimate the person’s total body water (TBW) and hence Vd of ethanol. To date, there aren’t any studies that compare Vd derived from anthropometric data with robust values measured empirically. From the literature we compiled information about the Vd of ethanol from drinking studies with 173 Caucasian males and 63 Caucasian females from Western Europe. These empirically derived values of Vd were then compared with estimates derived from various anthropometric equations. In males the Watson, Watson and Batt regression equation involving age, height and weight gave the most accurate results (bias was 0.00 L/Kg) and 95% confidence limits (CI) were ± 0.13 L/Kg. The equation derived by Forrest, which took into consideration a person’s body mass index (BMI), gave the best estimates of Vd for females; mean bias −0.01 L/Kg and 95% CI ± 0.15 L/Kg.

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