Evolution of emerging iPS cell-based therapies for age-related macular degeneration (AMD)

Alfonso Ávila-Robinson, Nazrul Islam

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Stem cell-based regenerative medicine is poised to revolutionize the way diseases are treated. In recent years, induced pluripotent stem (iPS) cells, a newly stem cell species, has attracted significant attention. This paper seeks to understand the pathways along which emerging clinical research efforts in the field of iPS cells is evolved. In particular, the empirical case of age-related macular degeneration (AMD) is used, which is the world-pioneering clinical application of iPS cells. In line with the literature, this study explores the interrelations between three different pathways, such as biomedical scientific understanding, development of medical technologies, and learning in clinical practice. For this, a techmining approach is used including co-term, co-citation, and direct citation methods. Scientific publications indexed in the Thomson Reuters' Web of Science and Elsevier's Scopus databases form the basis of the study. This research first explores the iPS cell research landscape through the construction of a co-term map, particularly stressing the location and intensity of disease-tackling efforts; then focus on the evolution of scientific knowledge on AMD through co-citation networks and the main path algorithm on direct citations. At the researcher level, the development of four different research groups working on cell therapies for AMD is evaluated through the software CitNetExplorer. By integrating these approaches, the result shows a wider picture of the complexities inherent in the translation of knowledge into revolutionary clinical methods.
Original languageEnglish
Title of host publicationManagement of the technology age
Subtitle of host publicationproceedings
EditorsDundar F. Kocaoglu
Place of PublicationPortland, OR
PublisherIEEE
Pages495-510
Number of pages16
ISBN (Electronic)9781890843311
ISBN (Print)9781890843328
DOIs
Publication statusPublished - 24 Sep 2015
Event2015 Portland International Conference on Management of Engineering and Technology: Management of the Technology Age - Hilton Portland and Executive Tower, Portland, United States
Duration: 2 Aug 20156 Aug 2015

Conference

Conference2015 Portland International Conference on Management of Engineering and Technology
Abbreviated titlePICMET '15
CountryUnited States
CityPortland
Period2/08/156/08/15

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Ávila-Robinson, A., & Islam, N. (2015). Evolution of emerging iPS cell-based therapies for age-related macular degeneration (AMD). In D. F. Kocaoglu (Ed.), Management of the technology age: proceedings (pp. 495-510). Portland, OR: IEEE . https://doi.org/10.1109/PICMET.2015.7273173
Ávila-Robinson, Alfonso ; Islam, Nazrul. / Evolution of emerging iPS cell-based therapies for age-related macular degeneration (AMD). Management of the technology age: proceedings. editor / Dundar F. Kocaoglu. Portland, OR : IEEE , 2015. pp. 495-510
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Ávila-Robinson, A & Islam, N 2015, Evolution of emerging iPS cell-based therapies for age-related macular degeneration (AMD). in DF Kocaoglu (ed.), Management of the technology age: proceedings. IEEE , Portland, OR, pp. 495-510, 2015 Portland International Conference on Management of Engineering and Technology, Portland, United States, 2/08/15. https://doi.org/10.1109/PICMET.2015.7273173

Evolution of emerging iPS cell-based therapies for age-related macular degeneration (AMD). / Ávila-Robinson, Alfonso; Islam, Nazrul.

Management of the technology age: proceedings. ed. / Dundar F. Kocaoglu. Portland, OR : IEEE , 2015. p. 495-510.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - Stem cell-based regenerative medicine is poised to revolutionize the way diseases are treated. In recent years, induced pluripotent stem (iPS) cells, a newly stem cell species, has attracted significant attention. This paper seeks to understand the pathways along which emerging clinical research efforts in the field of iPS cells is evolved. In particular, the empirical case of age-related macular degeneration (AMD) is used, which is the world-pioneering clinical application of iPS cells. In line with the literature, this study explores the interrelations between three different pathways, such as biomedical scientific understanding, development of medical technologies, and learning in clinical practice. For this, a techmining approach is used including co-term, co-citation, and direct citation methods. Scientific publications indexed in the Thomson Reuters' Web of Science and Elsevier's Scopus databases form the basis of the study. This research first explores the iPS cell research landscape through the construction of a co-term map, particularly stressing the location and intensity of disease-tackling efforts; then focus on the evolution of scientific knowledge on AMD through co-citation networks and the main path algorithm on direct citations. At the researcher level, the development of four different research groups working on cell therapies for AMD is evaluated through the software CitNetExplorer. By integrating these approaches, the result shows a wider picture of the complexities inherent in the translation of knowledge into revolutionary clinical methods.

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Ávila-Robinson A, Islam N. Evolution of emerging iPS cell-based therapies for age-related macular degeneration (AMD). In Kocaoglu DF, editor, Management of the technology age: proceedings. Portland, OR: IEEE . 2015. p. 495-510 https://doi.org/10.1109/PICMET.2015.7273173