Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release

Mu-Ru Xu, Meng Shi, David H. Bremner, Kan Sun, Hua-Li Nie, Jing Quan, Li-Min Zhu

Research output: Contribution to journalArticle

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Abstract

The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.
Original languageEnglish
Pages (from-to)209-216
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume135
Early online date19 Jul 2015
DOIs
Publication statusPublished - 1 Nov 2015

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Nanofibers
Galactose
Fabrication
Polymers
Pharmaceutical Preparations
Peanut Agglutinin
Electrospinning
Copolymerization
Free Radicals
Assays
Proteins
Copolymers
Monomers
Temperature

Cite this

Xu, Mu-Ru ; Shi, Meng ; Bremner, David H. ; Sun, Kan ; Nie, Hua-Li ; Quan, Jing ; Zhu, Li-Min. / Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release. In: Colloids and Surfaces B: Biointerfaces. 2015 ; Vol. 135. pp. 209-216.
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abstract = "The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.",
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Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release. / Xu, Mu-Ru; Shi, Meng; Bremner, David H.; Sun, Kan; Nie, Hua-Li; Quan, Jing; Zhu, Li-Min.

In: Colloids and Surfaces B: Biointerfaces, Vol. 135, 01.11.2015, p. 209-216.

Research output: Contribution to journalArticle

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AU - Bremner, David H.

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AU - Nie, Hua-Li

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AU - Zhu, Li-Min

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AB - The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.

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