Abstract
The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.
| Original language | English |
|---|---|
| Pages (from-to) | 209-216 |
| Number of pages | 8 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Volume | 135 |
| Early online date | 19 Jul 2015 |
| DOIs | |
| Publication status | Published - 1 Nov 2015 |
Fingerprint Dive into the research topics of 'Facile fabrication of P(OVNG-<i>co</i>-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release'. Together they form a unique fingerprint.
Cite this
Xu, M-R., Shi, M., Bremner, D. H., Sun, K., Nie, H-L., Quan, J., & Zhu, L-M. (2015). Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release. Colloids and Surfaces B: Biointerfaces, 135, 209-216. https://doi.org/10.1016/j.colsurfb.2015.07.041