Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release

Mu-Ru Xu, Meng Shi, David H. Bremner, Kan Sun, Hua-Li Nie, Jing Quan, Li-Min Zhu

    Research output: Contribution to journalArticle

    5 Citations (Scopus)
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    Abstract

    The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.
    Original languageEnglish
    Pages (from-to)209-216
    Number of pages8
    JournalColloids and Surfaces B: Biointerfaces
    Volume135
    Early online date19 Jul 2015
    DOIs
    Publication statusPublished - 1 Nov 2015

    Fingerprint

    Nanofibers
    Galactose
    Fabrication
    Polymers
    Pharmaceutical Preparations
    Peanut Agglutinin
    Electrospinning
    Copolymerization
    Free Radicals
    Assays
    Proteins
    Copolymers
    Monomers
    Temperature

    Cite this

    Xu, Mu-Ru ; Shi, Meng ; Bremner, David H. ; Sun, Kan ; Nie, Hua-Li ; Quan, Jing ; Zhu, Li-Min. / Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release. In: Colloids and Surfaces B: Biointerfaces. 2015 ; Vol. 135. pp. 209-216.
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    abstract = "The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.",
    author = "Mu-Ru Xu and Meng Shi and Bremner, {David H.} and Kan Sun and Hua-Li Nie and Jing Quan and Li-Min Zhu",
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    Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release. / Xu, Mu-Ru; Shi, Meng; Bremner, David H.; Sun, Kan; Nie, Hua-Li; Quan, Jing; Zhu, Li-Min.

    In: Colloids and Surfaces B: Biointerfaces, Vol. 135, 01.11.2015, p. 209-216.

    Research output: Contribution to journalArticle

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    AU - Xu, Mu-Ru

    AU - Shi, Meng

    AU - Bremner, David H.

    AU - Sun, Kan

    AU - Nie, Hua-Li

    AU - Quan, Jing

    AU - Zhu, Li-Min

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    AB - The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.

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