Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release

Mu-Ru Xu; Meng Shi; David H. Bremner; Kan Sun; Hua-Li Nie; Jing Quan; Li-Min Zhu

doi:10.1016/j.colsurfb.2015.07.041

Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release

Mu-Ru Xu, Meng Shi, David H. Bremner, Kan Sun, Hua-Li Nie, Jing Quan^*, Li-Min Zhu^*

^*Corresponding author for this work

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Abstract

The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.

Original language	English
Pages (from-to)	209-216
Number of pages	8
Journal	Colloids and Surfaces B: Biointerfaces
Volume	135
Early online date	19 Jul 2015
DOIs	https://doi.org/10.1016/j.colsurfb.2015.07.041
Publication status	Published - 1 Nov 2015

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Xu, M-R., Shi, M., Bremner, D. H., Sun, K., Nie, H-L., Quan, J., & Zhu, L-M. (2015). Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release. Colloids and Surfaces B: Biointerfaces, 135, 209-216. https://doi.org/10.1016/j.colsurfb.2015.07.041

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title = "Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release",

abstract = "The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.",

author = "Mu-Ru Xu and Meng Shi and Bremner, {David H.} and Kan Sun and Hua-Li Nie and Jing Quan and Li-Min Zhu",

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T1 - Facile fabrication of P(OVNG-co-NVCL) thermoresponsive double-hydrophilic glycopolymer nanofibers for sustained drug release

AU - Xu, Mu-Ru

AU - Shi, Meng

AU - Bremner, David H.

AU - Sun, Kan

AU - Nie, Hua-Li

AU - Quan, Jing

AU - Zhu, Li-Min

PY - 2015/11/1

Y1 - 2015/11/1

N2 - The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.

AB - The thermoresponsive double-hydrophilic glycopolymer (DHG), Poly (6-O-vinyl-nonanedioyl-D-galactose-co-N-vinylcaprolactam) (P(OVNG-co-NVCL)) was synthesized via a chemo-enzymatic process and a free radical copolymerization and the resulting nanofibers were fabricated using an electrospinning process. The desired lower critical solution temperature (LCST) between 32 and 40 °C of the DHG polymers was achieved by adjusting the molar fraction of galactose monomer in the copolymers during the synthesis. The thermoresponsive DHG polymers were found to have good cytocompatibility with Hela cells as determined by the MTT assay, and special recognition of the protein peanut agglutinin (PNA). The drug release properties of these newly designed thermoresponsive DHG P(OVNG-co-NVCL) nanofibers are temperature regulated, can target specific proteins and have the potential application in the field of sustained drug release.

U2 - 10.1016/j.colsurfb.2015.07.041

DO - 10.1016/j.colsurfb.2015.07.041

M3 - Article

VL - 135

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EP - 216

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

SN - 0927-7765

ER -

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Bremner_FacileFabrication_Author_2015Accepted author manuscript, 1.81 MBLicence: CC BY-NC-ND