Functionalized layered double hydroxide nanoparticles as an intelligent nanoplatform for synergistic photothermal therapy and chemotherapy of tumors

Yuhan Ye, David H. Bremner, Hongmei Zhang, Xia Chen, Jiadong Lou, Li-Min Zhu*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review


    In this work, a novel layered double hydroxide (LDH)-based multifunctional nanoplatform was built for synergistic temperature photothermal therapy (PTT)/chemotherapy. The platform was modified using the peptide B3int to target cancer cells with overexpression of integrin αvβ3. Indocyanine green (ICG) and doxorubicin (DOX) were loaded into the nanocarrier (LDH-PEG-B3int NPs) to form a system having a high DOX drug loading (18.62%) and a remarkable photothermal conversion efficiency of 25.38%. It also showed pH-responsive and near-infrared (NIR)-triggered DOX release. In vitro and in vivo studies indicated that the anti-tumor activity of the combined delivery system was significantly higher than that of a single delivery system. This co-delivery nanosystem may be helpful for future application in the clinical treatment of cancer.
    Original languageEnglish
    Article number112261
    Number of pages12
    JournalColloids and Surfaces B: Biointerfaces
    Early online date7 Dec 2021
    Publication statusE-pub ahead of print - 7 Dec 2021


    • Layered double hydroxide
    • Nano-drug delivery system
    • Stimulus-responsive drug release
    • B3int

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