Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa

Kirsty M.O. Brown, Sarah R. Bujac, Evleen T. Mann, David A. Campbell, Michael J. Stubbins, John E. Blundell, Kirsty Kiezebrink

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Abstract

Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.
Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalBiological Psychiatry
Volume61
Issue number3
DOIs
StatePublished - Feb 2007
Externally publishedYes

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Anorexia Nervosa
Genes
Single Nucleotide Polymorphism
Chromosomes, Human, Pair 1
Medical Genetics
Human Chromosomes
Genetic Predisposition to Disease
Diagnostic and Statistical Manual of Mental Disorders
Opioid Analgesics
Volunteers
Serotonin

Cite this

Brown, K. M. O., Bujac, S. R., Mann, E. T., Campbell, D. A., Stubbins, M. J., Blundell, J. E., & Kiezebrink, K. (2007). Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa. Biological Psychiatry, 61(3), 367-373. DOI: 10.1016/j.biopsych.2006.04.007

Brown, Kirsty M.O.; Bujac, Sarah R.; Mann, Evleen T.; Campbell, David A.; Stubbins, Michael J.; Blundell, John E.; Kiezebrink, Kirsty / Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa.

In: Biological Psychiatry, Vol. 61, No. 3, 02.2007, p. 367-373.

Research output: Contribution to journalArticle

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abstract = "Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.",
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Brown, KMO, Bujac, SR, Mann, ET, Campbell, DA, Stubbins, MJ, Blundell, JE & Kiezebrink, K 2007, 'Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa' Biological Psychiatry, vol 61, no. 3, pp. 367-373. DOI: 10.1016/j.biopsych.2006.04.007

Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa. / Brown, Kirsty M.O.; Bujac, Sarah R.; Mann, Evleen T.; Campbell, David A.; Stubbins, Michael J.; Blundell, John E.; Kiezebrink, Kirsty.

In: Biological Psychiatry, Vol. 61, No. 3, 02.2007, p. 367-373.

Research output: Contribution to journalArticle

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T1 - Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa

AU - Brown,Kirsty M.O.

AU - Bujac,Sarah R.

AU - Mann,Evleen T.

AU - Campbell,David A.

AU - Stubbins,Michael J.

AU - Blundell,John E.

AU - Kiezebrink,Kirsty

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N2 - Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.

AB - Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.

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Brown KMO, Bujac SR, Mann ET, Campbell DA, Stubbins MJ, Blundell JE et al. Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa. Biological Psychiatry. 2007 Feb;61(3):367-373. Available from, DOI: 10.1016/j.biopsych.2006.04.007