Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa

Kirsty M.O. Brown; Sarah R. Bujac; Evleen T. Mann; David A. Campbell; Michael J. Stubbins; John E. Blundell; Kirsty Kiezebrink

doi:10.1016/j.biopsych.2006.04.007

Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa

Kirsty M.O. Brown, Sarah R. Bujac, Evleen T. Mann, David A. Campbell, Michael J. Stubbins, John E. Blundell, Kirsty Kiezebrink

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.

Original language	English
Pages (from-to)	367-373
Number of pages	7
Journal	Biological Psychiatry
Volume	61
Issue number	3
DOIs	https://doi.org/10.1016/j.biopsych.2006.04.007
Publication status	Published - Feb 2007
Externally published	Yes

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@article{379fac0c9fe6456dadc90b979abf442d,

title = "Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa",

abstract = "Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.",

author = "Brown, {Kirsty M.O.} and Bujac, {Sarah R.} and Mann, {Evleen T.} and Campbell, {David A.} and Stubbins, {Michael J.} and Blundell, {John E.} and Kirsty Kiezebrink",

year = "2007",

month = feb,

doi = "10.1016/j.biopsych.2006.04.007",

language = "English",

volume = "61",

pages = "367--373",

journal = "Biological Psychiatry",

number = "3",

}

Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa. / Brown, Kirsty M.O.; Bujac, Sarah R.; Mann, Evleen T.; Campbell, David A.; Stubbins, Michael J.; Blundell, John E.; Kiezebrink, Kirsty.

In: Biological Psychiatry, Vol. 61, No. 3, 02.2007, p. 367-373.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa

AU - Brown, Kirsty M.O.

AU - Bujac, Sarah R.

AU - Mann, Evleen T.

AU - Campbell, David A.

AU - Stubbins, Michael J.

AU - Blundell, John E.

AU - Kiezebrink, Kirsty

PY - 2007/2

Y1 - 2007/2

N2 - Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.

AB - Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.

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DO - 10.1016/j.biopsych.2006.04.007

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