Abstract
Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this
susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers.
Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge
AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN.
Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.
| Original language | English |
|---|---|
| Pages (from-to) | 367-373 |
| Number of pages | 7 |
| Journal | Biological Psychiatry |
| Volume | 61 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Feb 2007 |
| Externally published | Yes |
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Cite this
Brown, K. M. O., Bujac, S. R., Mann, E. T., Campbell, D. A., Stubbins, M. J., Blundell, J. E., & Kiezebrink, K. (2007). Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa. Biological Psychiatry, 61(3), 367-373. https://doi.org/10.1016/j.biopsych.2006.04.007