Gene transfer in higher animals: theoretical considerations and key concepts

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    20 Citations (Scopus)

    Abstract

    Gene transfer technology provides the ability to genetically manipulate the cells of higher animals. Gene transfer permits both germline and somatic alterations. Such genetic manipulation is the basis for animal transgenesis goals and gene therapy attempts. Improvements in gene transfer are required in terms of transgene design to permit gene targeting, and in terms of transfection approaches to allow improved transgene uptake efficiencies.
    Original languageEnglish
    Pages (from-to)1-22
    Number of pages22
    JournalJournal of Biotechnology
    Volume99
    Issue number1
    DOIs
    Publication statusPublished - Oct 2002

    Keywords

    • Gene therapy
    • Gene transfer
    • Transfection
    • Gene targeting
    • Nuclear transfer
    • Transgenesis

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