Going retro: oxidative stress biomarkers in modern redox biology

Nikos V. Margaritelis, James N. Cobley, Vassilis Paschalis, Aristidis S. Veskoukis, Anastasios A. Theodorou, Antonios Kyparos, Michalis G. Nikolaidis

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


The field of redox biology is inherently intertwined with oxidative stress biomarkers. Oxidative stress biomarkers have been utilized for many different objectives. Our analysis indicates that oxidative stress biomarkers have several salient applications: (1) diagnosing oxidative stress, (2) pinpointing likely redox components in a physiological or pathological process, and (3) estimating the severity, progression and/or regression of a disease. On the contrary, oxidative stress biomarkers do not report on redox signaling. Alternative approaches to gain more mechanistic insights are: (1) measuring molecules that are integrated in pathways linking redox biochemistry with physiology, (2) using the exomarker approach and (3) exploiting -omics techniques. More sophisticated approaches and large trials are needed to establish oxidative stress biomarkers in the clinical setting.
Original languageEnglish
Pages (from-to)2-12
Number of pages11
JournalFree Radical Biology and Medicine
Publication statusPublished - 17 Feb 2016


  • Biomarkers
  • Oxidative stress
  • Redox signaling
  • Physiology
  • Pathology


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