Going retro

oxidative stress biomarkers in modern redox biology

Nikos V. Margaritelis, James N. Cobley, Vassilis Paschalis, Aristidis S. Veskoukis, Anastasios A. Theodorou, Antonios Kyparos, Michalis G. Nikolaidis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The field of redox biology is inherently intertwined with oxidative stress biomarkers. Oxidative stress biomarkers have been utilized for many different objectives. Our analysis indicates that oxidative stress biomarkers have several salient applications: (1) diagnosing oxidative stress, (2) pinpointing likely redox components in a physiological or pathological process, and (3) estimating the severity, progression and/or regression of a disease. On the contrary, oxidative stress biomarkers do not report on redox signaling. Alternative approaches to gain more mechanistic insights are: (1) measuring molecules that are integrated in pathways linking redox biochemistry with physiology, (2) using the exomarker approach and (3) exploiting -omics techniques. More sophisticated approaches and large trials are needed to establish oxidative stress biomarkers in the clinical setting.
Original languageEnglish
Pages (from-to)2-12
Number of pages11
JournalFree Radical Biology and Medicine
Volume98
DOIs
Publication statusPublished - 17 Feb 2016

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Oxidative stress
Biomarkers
Oxidation-Reduction
Oxidative Stress
Physiological Phenomena
Biochemistry
Physiology
Pathologic Processes
Molecules

Cite this

Margaritelis, N. V., Cobley, J. N., Paschalis, V., Veskoukis, A. S., Theodorou, A. A., Kyparos, A., & Nikolaidis, M. G. (2016). Going retro: oxidative stress biomarkers in modern redox biology. Free Radical Biology and Medicine, 98, 2-12. https://doi.org/10.1016/j.freeradbiomed.2016.02.005
Margaritelis, Nikos V. ; Cobley, James N. ; Paschalis, Vassilis ; Veskoukis, Aristidis S. ; Theodorou, Anastasios A. ; Kyparos, Antonios ; Nikolaidis, Michalis G. / Going retro : oxidative stress biomarkers in modern redox biology. In: Free Radical Biology and Medicine. 2016 ; Vol. 98. pp. 2-12.
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Margaritelis, NV, Cobley, JN, Paschalis, V, Veskoukis, AS, Theodorou, AA, Kyparos, A & Nikolaidis, MG 2016, 'Going retro: oxidative stress biomarkers in modern redox biology', Free Radical Biology and Medicine, vol. 98, pp. 2-12. https://doi.org/10.1016/j.freeradbiomed.2016.02.005

Going retro : oxidative stress biomarkers in modern redox biology. / Margaritelis, Nikos V.; Cobley, James N.; Paschalis, Vassilis; Veskoukis, Aristidis S.; Theodorou, Anastasios A.; Kyparos, Antonios; Nikolaidis, Michalis G.

In: Free Radical Biology and Medicine, Vol. 98, 17.02.2016, p. 2-12.

Research output: Contribution to journalArticle

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AU - Theodorou, Anastasios A.

AU - Kyparos, Antonios

AU - Nikolaidis, Michalis G.

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Margaritelis NV, Cobley JN, Paschalis V, Veskoukis AS, Theodorou AA, Kyparos A et al. Going retro: oxidative stress biomarkers in modern redox biology. Free Radical Biology and Medicine. 2016 Feb 17;98:2-12. https://doi.org/10.1016/j.freeradbiomed.2016.02.005