TY - JOUR
T1 - Going retro
T2 - oxidative stress biomarkers in modern redox biology
AU - Margaritelis, Nikos V.
AU - Cobley, James N.
AU - Paschalis, Vassilis
AU - Veskoukis, Aristidis S.
AU - Theodorou, Anastasios A.
AU - Kyparos, Antonios
AU - Nikolaidis, Michalis G.
PY - 2016/2/17
Y1 - 2016/2/17
N2 - The field of redox biology is inherently intertwined with oxidative stress biomarkers. Oxidative stress biomarkers have been utilized for many different objectives. Our analysis indicates that oxidative stress biomarkers have several salient applications: (1) diagnosing oxidative stress, (2) pinpointing likely redox components in a physiological or pathological process, and (3) estimating the severity, progression and/or regression of a disease. On the contrary, oxidative stress biomarkers do not report on redox signaling. Alternative approaches to gain more mechanistic insights are: (1) measuring molecules that are integrated in pathways linking redox biochemistry with physiology, (2) using the exomarker approach and (3) exploiting -omics techniques. More sophisticated approaches and large trials are needed to establish oxidative stress biomarkers in the clinical setting.
AB - The field of redox biology is inherently intertwined with oxidative stress biomarkers. Oxidative stress biomarkers have been utilized for many different objectives. Our analysis indicates that oxidative stress biomarkers have several salient applications: (1) diagnosing oxidative stress, (2) pinpointing likely redox components in a physiological or pathological process, and (3) estimating the severity, progression and/or regression of a disease. On the contrary, oxidative stress biomarkers do not report on redox signaling. Alternative approaches to gain more mechanistic insights are: (1) measuring molecules that are integrated in pathways linking redox biochemistry with physiology, (2) using the exomarker approach and (3) exploiting -omics techniques. More sophisticated approaches and large trials are needed to establish oxidative stress biomarkers in the clinical setting.
U2 - 10.1016/j.freeradbiomed.2016.02.005
DO - 10.1016/j.freeradbiomed.2016.02.005
M3 - Article
SN - 0891-5849
VL - 98
SP - 2
EP - 12
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
ER -