Influence of priming exercise and type 2 diabetes on oxygen uptake and muscle deoxygenation kinetics during submaximal exercise

Joel Rocha, Norita Gildea, Donal O'Shea, Simon Green, Mikel Egana

Research output: Contribution to conferenceAbstract

Abstract

Middle aged and young adults with uncomplicated type 2 diabetes (T2D) show a slowed adjustment of oxidative metabolism during metabolic transitions (i.e. .oxygen uptake, VO2 kinetics) due to progressive limitations of both O2 delivery and utilisation. Priming exercise (PE) has been shown to increase the speed of adjustment of oxidative metabolism during subsequent moderate-intensity step transitions in healthy adults presenting initially slow VO2 kinetics. We tested the hypothesis that PE would increase the speed of the adjustment of the primary phase (taup, τp) of VO2 during moderate intensity cycling in T2D and that this would be due to a better matching of O2 delivery to utilisation. Ten middle-aged participants with uncomplicated T2D (50.7 ± 9.0 years, 30.4 ± 5.3 kg/m2; 7 men / 3 women) and 10 non-diabetic (ND) controls (44.4 ± 9.6 years, 31.1 ± 4.1 kg/m2; 7 men / 3 women) were recruited. Participants completed four bouts of constant-load cycling at 80% of their ventilatory threshold previously established during a ramp incremental test. Two of these constant-load bouts were completed without priming exercise (ModA) and two bouts were undertaken with prior heavy intensity priming exercise (ModB). VO2 kinetics was calculated from continuously measured breath-by-breath data, while the rate of muscle deoxygenation (i.e., deoxygenated hemoglobin, HHb) and tissue oxygen saturation (i.e., tissue oxygenation index) were continuously measured by Near-infrared spectroscopy (NIRS) at the vastus lateralis muscle. The time constant of the primary phase, τp, was significantly slower in T2D, but PE significantly (P<0.05) reduced τp in both groups by a similar magnitude (T2D, 48.29 ± 11.5 vs. 35.9±13.0 s; ND, 34.0 ± 9.6 vs. 26.8 ± 10.5 s). The adjustment of deoxygenated heamoglobin (HHb) did not show any differences between groups but its amplitude was increased after PE (P=0.036). Total tissue oxygenation at baseline and end of exercise was lower in T2D (P<0.05), however, PE increased tissue oxygenation index at baseline (p=0.002) and the delta values at the end of exercise (p=0.001) in both groups. The HHb/VO2 ratios (20-120s) were reduced after PE (T2D, 1.12 ± 0.12 vs 1.07 ± 0.12; ND, 1.03 ± 0.13 vs 1.00 ± 0.12; P=0.038). These preliminary data support that in middle-aged adults with T2D, priming exercise prior to moderate-intensity exercise, beneficially affects the speed of adjustment of oxidative metabolism, possibly due to the partial improvement in the transient mismatch of muscle O2 delivery relative to utilisation.
Original languageEnglish
Publication statusPublished - 6 Mar 2016
Externally publishedYes
EventBiomedical Basis of Elite Performance 2016 - East Midlands Conference Centre, Nottingham, United Kingdom
Duration: 6 Mar 20168 Mar 2016
http://www.physoc.org/bbep2016/

Conference

ConferenceBiomedical Basis of Elite Performance 2016
CountryUnited Kingdom
CityNottingham
Period6/03/168/03/16
Internet address

Fingerprint

Type 2 Diabetes Mellitus
Exercise
Oxygen
Muscles
Architectural Accessibility
Near-Infrared Spectroscopy
Quadriceps Muscle
Young Adult
Hemoglobins

Cite this

Rocha, J., Gildea, N., O'Shea, D., Green, S., & Egana, M. (2016). Influence of priming exercise and type 2 diabetes on oxygen uptake and muscle deoxygenation kinetics during submaximal exercise. Abstract from Biomedical Basis of Elite Performance 2016, Nottingham, United Kingdom.
Rocha, Joel ; Gildea, Norita ; O'Shea, Donal ; Green, Simon ; Egana, Mikel. / Influence of priming exercise and type 2 diabetes on oxygen uptake and muscle deoxygenation kinetics during submaximal exercise. Abstract from Biomedical Basis of Elite Performance 2016, Nottingham, United Kingdom.
@conference{6373da88890848dda4f973963c24e9f8,
title = "Influence of priming exercise and type 2 diabetes on oxygen uptake and muscle deoxygenation kinetics during submaximal exercise",
abstract = "Middle aged and young adults with uncomplicated type 2 diabetes (T2D) show a slowed adjustment of oxidative metabolism during metabolic transitions (i.e. .oxygen uptake, VO2 kinetics) due to progressive limitations of both O2 delivery and utilisation. Priming exercise (PE) has been shown to increase the speed of adjustment of oxidative metabolism during subsequent moderate-intensity step transitions in healthy adults presenting initially slow VO2 kinetics. We tested the hypothesis that PE would increase the speed of the adjustment of the primary phase (taup, τp) of VO2 during moderate intensity cycling in T2D and that this would be due to a better matching of O2 delivery to utilisation. Ten middle-aged participants with uncomplicated T2D (50.7 ± 9.0 years, 30.4 ± 5.3 kg/m2; 7 men / 3 women) and 10 non-diabetic (ND) controls (44.4 ± 9.6 years, 31.1 ± 4.1 kg/m2; 7 men / 3 women) were recruited. Participants completed four bouts of constant-load cycling at 80{\%} of their ventilatory threshold previously established during a ramp incremental test. Two of these constant-load bouts were completed without priming exercise (ModA) and two bouts were undertaken with prior heavy intensity priming exercise (ModB). VO2 kinetics was calculated from continuously measured breath-by-breath data, while the rate of muscle deoxygenation (i.e., deoxygenated hemoglobin, HHb) and tissue oxygen saturation (i.e., tissue oxygenation index) were continuously measured by Near-infrared spectroscopy (NIRS) at the vastus lateralis muscle. The time constant of the primary phase, τp, was significantly slower in T2D, but PE significantly (P<0.05) reduced τp in both groups by a similar magnitude (T2D, 48.29 ± 11.5 vs. 35.9±13.0 s; ND, 34.0 ± 9.6 vs. 26.8 ± 10.5 s). The adjustment of deoxygenated heamoglobin (HHb) did not show any differences between groups but its amplitude was increased after PE (P=0.036). Total tissue oxygenation at baseline and end of exercise was lower in T2D (P<0.05), however, PE increased tissue oxygenation index at baseline (p=0.002) and the delta values at the end of exercise (p=0.001) in both groups. The HHb/VO2 ratios (20-120s) were reduced after PE (T2D, 1.12 ± 0.12 vs 1.07 ± 0.12; ND, 1.03 ± 0.13 vs 1.00 ± 0.12; P=0.038). These preliminary data support that in middle-aged adults with T2D, priming exercise prior to moderate-intensity exercise, beneficially affects the speed of adjustment of oxidative metabolism, possibly due to the partial improvement in the transient mismatch of muscle O2 delivery relative to utilisation.",
author = "Joel Rocha and Norita Gildea and Donal O'Shea and Simon Green and Mikel Egana",
year = "2016",
month = "3",
day = "6",
language = "English",
note = "Biomedical Basis of Elite Performance 2016 ; Conference date: 06-03-2016 Through 08-03-2016",
url = "http://www.physoc.org/bbep2016/",

}

Rocha, J, Gildea, N, O'Shea, D, Green, S & Egana, M 2016, 'Influence of priming exercise and type 2 diabetes on oxygen uptake and muscle deoxygenation kinetics during submaximal exercise' Biomedical Basis of Elite Performance 2016, Nottingham, United Kingdom, 6/03/16 - 8/03/16, .

Influence of priming exercise and type 2 diabetes on oxygen uptake and muscle deoxygenation kinetics during submaximal exercise. / Rocha, Joel; Gildea, Norita; O'Shea, Donal; Green, Simon; Egana, Mikel.

2016. Abstract from Biomedical Basis of Elite Performance 2016, Nottingham, United Kingdom.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Influence of priming exercise and type 2 diabetes on oxygen uptake and muscle deoxygenation kinetics during submaximal exercise

AU - Rocha, Joel

AU - Gildea, Norita

AU - O'Shea, Donal

AU - Green, Simon

AU - Egana, Mikel

PY - 2016/3/6

Y1 - 2016/3/6

N2 - Middle aged and young adults with uncomplicated type 2 diabetes (T2D) show a slowed adjustment of oxidative metabolism during metabolic transitions (i.e. .oxygen uptake, VO2 kinetics) due to progressive limitations of both O2 delivery and utilisation. Priming exercise (PE) has been shown to increase the speed of adjustment of oxidative metabolism during subsequent moderate-intensity step transitions in healthy adults presenting initially slow VO2 kinetics. We tested the hypothesis that PE would increase the speed of the adjustment of the primary phase (taup, τp) of VO2 during moderate intensity cycling in T2D and that this would be due to a better matching of O2 delivery to utilisation. Ten middle-aged participants with uncomplicated T2D (50.7 ± 9.0 years, 30.4 ± 5.3 kg/m2; 7 men / 3 women) and 10 non-diabetic (ND) controls (44.4 ± 9.6 years, 31.1 ± 4.1 kg/m2; 7 men / 3 women) were recruited. Participants completed four bouts of constant-load cycling at 80% of their ventilatory threshold previously established during a ramp incremental test. Two of these constant-load bouts were completed without priming exercise (ModA) and two bouts were undertaken with prior heavy intensity priming exercise (ModB). VO2 kinetics was calculated from continuously measured breath-by-breath data, while the rate of muscle deoxygenation (i.e., deoxygenated hemoglobin, HHb) and tissue oxygen saturation (i.e., tissue oxygenation index) were continuously measured by Near-infrared spectroscopy (NIRS) at the vastus lateralis muscle. The time constant of the primary phase, τp, was significantly slower in T2D, but PE significantly (P<0.05) reduced τp in both groups by a similar magnitude (T2D, 48.29 ± 11.5 vs. 35.9±13.0 s; ND, 34.0 ± 9.6 vs. 26.8 ± 10.5 s). The adjustment of deoxygenated heamoglobin (HHb) did not show any differences between groups but its amplitude was increased after PE (P=0.036). Total tissue oxygenation at baseline and end of exercise was lower in T2D (P<0.05), however, PE increased tissue oxygenation index at baseline (p=0.002) and the delta values at the end of exercise (p=0.001) in both groups. The HHb/VO2 ratios (20-120s) were reduced after PE (T2D, 1.12 ± 0.12 vs 1.07 ± 0.12; ND, 1.03 ± 0.13 vs 1.00 ± 0.12; P=0.038). These preliminary data support that in middle-aged adults with T2D, priming exercise prior to moderate-intensity exercise, beneficially affects the speed of adjustment of oxidative metabolism, possibly due to the partial improvement in the transient mismatch of muscle O2 delivery relative to utilisation.

AB - Middle aged and young adults with uncomplicated type 2 diabetes (T2D) show a slowed adjustment of oxidative metabolism during metabolic transitions (i.e. .oxygen uptake, VO2 kinetics) due to progressive limitations of both O2 delivery and utilisation. Priming exercise (PE) has been shown to increase the speed of adjustment of oxidative metabolism during subsequent moderate-intensity step transitions in healthy adults presenting initially slow VO2 kinetics. We tested the hypothesis that PE would increase the speed of the adjustment of the primary phase (taup, τp) of VO2 during moderate intensity cycling in T2D and that this would be due to a better matching of O2 delivery to utilisation. Ten middle-aged participants with uncomplicated T2D (50.7 ± 9.0 years, 30.4 ± 5.3 kg/m2; 7 men / 3 women) and 10 non-diabetic (ND) controls (44.4 ± 9.6 years, 31.1 ± 4.1 kg/m2; 7 men / 3 women) were recruited. Participants completed four bouts of constant-load cycling at 80% of their ventilatory threshold previously established during a ramp incremental test. Two of these constant-load bouts were completed without priming exercise (ModA) and two bouts were undertaken with prior heavy intensity priming exercise (ModB). VO2 kinetics was calculated from continuously measured breath-by-breath data, while the rate of muscle deoxygenation (i.e., deoxygenated hemoglobin, HHb) and tissue oxygen saturation (i.e., tissue oxygenation index) were continuously measured by Near-infrared spectroscopy (NIRS) at the vastus lateralis muscle. The time constant of the primary phase, τp, was significantly slower in T2D, but PE significantly (P<0.05) reduced τp in both groups by a similar magnitude (T2D, 48.29 ± 11.5 vs. 35.9±13.0 s; ND, 34.0 ± 9.6 vs. 26.8 ± 10.5 s). The adjustment of deoxygenated heamoglobin (HHb) did not show any differences between groups but its amplitude was increased after PE (P=0.036). Total tissue oxygenation at baseline and end of exercise was lower in T2D (P<0.05), however, PE increased tissue oxygenation index at baseline (p=0.002) and the delta values at the end of exercise (p=0.001) in both groups. The HHb/VO2 ratios (20-120s) were reduced after PE (T2D, 1.12 ± 0.12 vs 1.07 ± 0.12; ND, 1.03 ± 0.13 vs 1.00 ± 0.12; P=0.038). These preliminary data support that in middle-aged adults with T2D, priming exercise prior to moderate-intensity exercise, beneficially affects the speed of adjustment of oxidative metabolism, possibly due to the partial improvement in the transient mismatch of muscle O2 delivery relative to utilisation.

M3 - Abstract

ER -

Rocha J, Gildea N, O'Shea D, Green S, Egana M. Influence of priming exercise and type 2 diabetes on oxygen uptake and muscle deoxygenation kinetics during submaximal exercise. 2016. Abstract from Biomedical Basis of Elite Performance 2016, Nottingham, United Kingdom.