Influence of priming exercise on oxygen uptake and muscle deoxygenation kinetics during moderate-intensity cycling in type 2 diabetes

Joel Rocha, Norita Gildea, Donal O'Shea, Simon Green, Mikel Egaña*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The pulmonary oxygen uptake (V̇O2) kinetics during the transition to moderate-intensity exercise is slowed in individuals with type 2 diabetes (T2D), at least in part due to limitations in O2 delivery. The present study tested the hypothesis that a prior heavy-intensity warm-up or 'priming exercise' (PE) bout would accelerate V̇O2 kinetics in T2D, due to a better matching of O2 delivery to utilisation. Twelve middle-aged individuals with T2D and 12 healthy controls (ND) completed moderate-intensity constant-load cycling bouts either without (ModA) or with (ModB) prior PE. The rate of muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration, [HHb+Mb]) and oxygenation (i.e. total oxygenation index, TOI) were continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. The local matching of O2 delivery to O2 utilization was assessed by the Δ[HHb+Mb]/ΔV̇O2 ratio. Both groups demonstrated an accelerated V̇O2 kinetics response during ModB compared with ModA (T2D: 32±9 vs. 42±12 s; ND: 28±9 vs. 34±8 s), and an elevated muscle oxygenation throughout ModB, while the [HHb+Mb] amplitude was greater during ModB only in individuals with T2D. The [HHb+Mb] kinetics remained unchanged in both groups. In T2D ModB was associated with a decrease in the 'overshoot' relative to steady-state in the Δ[HHb+Mb]/ΔV̇O2 ratio (1.17±0.17 vs. 1.05±0.15), while no overshoot was observed in the control group prior to (1.04±0.12) or after (1.01±0.12) PE. Our findings support a favourable priming-induced acceleration of the V̇O2 kinetics response in middle-aged individuals with uncomplicated T2D attributed to an enhanced matching of microvascular O2 delivery to utilisation.

Original languageEnglish
Pages (from-to)1140-1149
Number of pages10
JournalJournal of Applied Physiology
Volume127
Issue number4
Early online date15 Aug 2019
DOIs
Publication statusPublished - 14 Oct 2019

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Type 2 Diabetes Mellitus
Oxygen
Muscles
Near-Infrared Spectroscopy
Myoglobin
Quadriceps Muscle
Hemoglobins
Lung
Control Groups

Cite this

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title = "Influence of priming exercise on oxygen uptake and muscle deoxygenation kinetics during moderate-intensity cycling in type 2 diabetes",
abstract = "The pulmonary oxygen uptake (V̇O2) kinetics during the transition to moderate-intensity exercise is slowed in individuals with type 2 diabetes (T2D), at least in part due to limitations in O2 delivery. The present study tested the hypothesis that a prior heavy-intensity warm-up or 'priming exercise' (PE) bout would accelerate V̇O2 kinetics in T2D, due to a better matching of O2 delivery to utilisation. Twelve middle-aged individuals with T2D and 12 healthy controls (ND) completed moderate-intensity constant-load cycling bouts either without (ModA) or with (ModB) prior PE. The rate of muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration, [HHb+Mb]) and oxygenation (i.e. total oxygenation index, TOI) were continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. The local matching of O2 delivery to O2 utilization was assessed by the Δ[HHb+Mb]/ΔV̇O2 ratio. Both groups demonstrated an accelerated V̇O2 kinetics response during ModB compared with ModA (T2D: 32±9 vs. 42±12 s; ND: 28±9 vs. 34±8 s), and an elevated muscle oxygenation throughout ModB, while the [HHb+Mb] amplitude was greater during ModB only in individuals with T2D. The [HHb+Mb] kinetics remained unchanged in both groups. In T2D ModB was associated with a decrease in the 'overshoot' relative to steady-state in the Δ[HHb+Mb]/ΔV̇O2 ratio (1.17±0.17 vs. 1.05±0.15), while no overshoot was observed in the control group prior to (1.04±0.12) or after (1.01±0.12) PE. Our findings support a favourable priming-induced acceleration of the V̇O2 kinetics response in middle-aged individuals with uncomplicated T2D attributed to an enhanced matching of microvascular O2 delivery to utilisation.",
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Influence of priming exercise on oxygen uptake and muscle deoxygenation kinetics during moderate-intensity cycling in type 2 diabetes. / Rocha, Joel; Gildea, Norita; O'Shea, Donal; Green, Simon; Egaña, Mikel.

In: Journal of Applied Physiology, Vol. 127, No. 4, 14.10.2019, p. 1140-1149.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Influence of priming exercise on oxygen uptake and muscle deoxygenation kinetics during moderate-intensity cycling in type 2 diabetes

AU - Rocha, Joel

AU - Gildea, Norita

AU - O'Shea, Donal

AU - Green, Simon

AU - Egaña, Mikel

PY - 2019/10/14

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N2 - The pulmonary oxygen uptake (V̇O2) kinetics during the transition to moderate-intensity exercise is slowed in individuals with type 2 diabetes (T2D), at least in part due to limitations in O2 delivery. The present study tested the hypothesis that a prior heavy-intensity warm-up or 'priming exercise' (PE) bout would accelerate V̇O2 kinetics in T2D, due to a better matching of O2 delivery to utilisation. Twelve middle-aged individuals with T2D and 12 healthy controls (ND) completed moderate-intensity constant-load cycling bouts either without (ModA) or with (ModB) prior PE. The rate of muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration, [HHb+Mb]) and oxygenation (i.e. total oxygenation index, TOI) were continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. The local matching of O2 delivery to O2 utilization was assessed by the Δ[HHb+Mb]/ΔV̇O2 ratio. Both groups demonstrated an accelerated V̇O2 kinetics response during ModB compared with ModA (T2D: 32±9 vs. 42±12 s; ND: 28±9 vs. 34±8 s), and an elevated muscle oxygenation throughout ModB, while the [HHb+Mb] amplitude was greater during ModB only in individuals with T2D. The [HHb+Mb] kinetics remained unchanged in both groups. In T2D ModB was associated with a decrease in the 'overshoot' relative to steady-state in the Δ[HHb+Mb]/ΔV̇O2 ratio (1.17±0.17 vs. 1.05±0.15), while no overshoot was observed in the control group prior to (1.04±0.12) or after (1.01±0.12) PE. Our findings support a favourable priming-induced acceleration of the V̇O2 kinetics response in middle-aged individuals with uncomplicated T2D attributed to an enhanced matching of microvascular O2 delivery to utilisation.

AB - The pulmonary oxygen uptake (V̇O2) kinetics during the transition to moderate-intensity exercise is slowed in individuals with type 2 diabetes (T2D), at least in part due to limitations in O2 delivery. The present study tested the hypothesis that a prior heavy-intensity warm-up or 'priming exercise' (PE) bout would accelerate V̇O2 kinetics in T2D, due to a better matching of O2 delivery to utilisation. Twelve middle-aged individuals with T2D and 12 healthy controls (ND) completed moderate-intensity constant-load cycling bouts either without (ModA) or with (ModB) prior PE. The rate of muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration, [HHb+Mb]) and oxygenation (i.e. total oxygenation index, TOI) were continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. The local matching of O2 delivery to O2 utilization was assessed by the Δ[HHb+Mb]/ΔV̇O2 ratio. Both groups demonstrated an accelerated V̇O2 kinetics response during ModB compared with ModA (T2D: 32±9 vs. 42±12 s; ND: 28±9 vs. 34±8 s), and an elevated muscle oxygenation throughout ModB, while the [HHb+Mb] amplitude was greater during ModB only in individuals with T2D. The [HHb+Mb] kinetics remained unchanged in both groups. In T2D ModB was associated with a decrease in the 'overshoot' relative to steady-state in the Δ[HHb+Mb]/ΔV̇O2 ratio (1.17±0.17 vs. 1.05±0.15), while no overshoot was observed in the control group prior to (1.04±0.12) or after (1.01±0.12) PE. Our findings support a favourable priming-induced acceleration of the V̇O2 kinetics response in middle-aged individuals with uncomplicated T2D attributed to an enhanced matching of microvascular O2 delivery to utilisation.

U2 - 10.1152/japplphysiol.00344.2019

DO - 10.1152/japplphysiol.00344.2019

M3 - Article

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VL - 127

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JO - Journal of Applied Physiology

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