Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise

Norita Gildea, Joel Rocha, Adam McDermott, Donal O'Shea, Simon Green, Mikel Egaña*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that type 2 diabetes (T2D) alters the profile of muscle fractional oxygen (O2) extraction (near-infrared spectroscopy) during incremental cycle exercise. Seventeen middle-aged individuals with uncomplicated T2D and 17 controls performed an upright ramp test to exhaustion. The rate of muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration, Δ[HHb+Mb]) profiles of the vastus lateralis muscle were normalised to 100% of the response, plotted against % power output (PO) and fitted with a double linear regression model. Peak oxygen uptake was significantly (P < 0.05) reduced in individuals with T2D. The %Δ[HHb+Mb]/%PO slope of the first linear segment of the double linear regression function was significantly (P < 0.05) steeper in T2D than controls (1.81±0.61 vs 1.35±0.43). Both groups displayed a near-plateau in Δ[HHb+Mb] at an exercise intensity (%PO) not different amongst them. Such findings suggest that a reduced O2 delivery to active muscles is an important underlying cause of exercise intolerance during a maximum graded test in middle-aged individuals with T2D.

Original languageEnglish
Article number103258
Number of pages7
JournalRespiratory Physiology and Neurobiology
Volume269
Early online date23 Jul 2019
DOIs
Publication statusPublished - 1 Nov 2019

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Architectural Accessibility
Type 2 Diabetes Mellitus
Muscles
Linear Models
Oxygen
Near-Infrared Spectroscopy
Myoglobin
Quadriceps Muscle
Hemoglobins

Cite this

Gildea, Norita ; Rocha, Joel ; McDermott, Adam ; O'Shea, Donal ; Green, Simon ; Egaña, Mikel. / Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise. In: Respiratory Physiology and Neurobiology. 2019 ; Vol. 269.
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Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise. / Gildea, Norita; Rocha, Joel; McDermott, Adam; O'Shea, Donal; Green, Simon; Egaña, Mikel.

In: Respiratory Physiology and Neurobiology, Vol. 269, 103258, 01.11.2019.

Research output: Contribution to journalArticle

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AU - Gildea, Norita

AU - Rocha, Joel

AU - McDermott, Adam

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AU - Green, Simon

AU - Egaña, Mikel

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