Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise

Norita Gildea; Joel Rocha; Adam McDermott; Donal O'Shea; Simon Green; Mikel Egaña

doi:10.1016/j.resp.2019.103258

Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise

Norita Gildea, Joel Rocha, Adam McDermott, Donal O'Shea, Simon Green, Mikel Egaña^*

^*Corresponding author for this work

SAS - SES- Sports and Exercise Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

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Abstract

We tested the hypothesis that type 2 diabetes (T2D) alters the profile of muscle fractional oxygen (O₂) extraction (near-infrared spectroscopy) during incremental cycle exercise. Seventeen middle-aged individuals with uncomplicated T2D and 17 controls performed an upright ramp test to exhaustion. The rate of muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration, Δ[HHb+Mb]) profiles of the vastus lateralis muscle were normalised to 100% of the response, plotted against % power output (PO) and fitted with a double linear regression model. Peak oxygen uptake was significantly (P < 0.05) reduced in individuals with T2D. The %Δ[HHb+Mb]/%PO slope of the first linear segment of the double linear regression function was significantly (P < 0.05) steeper in T2D than controls (1.81±0.61 vs 1.35±0.43). Both groups displayed a near-plateau in Δ[HHb+Mb] at an exercise intensity (%PO) not different amongst them. Such findings suggest that a reduced O₂ delivery to active muscles is an important underlying cause of exercise intolerance during a maximum graded test in middle-aged individuals with T2D.

Original language	English
Article number	103258
Number of pages	7
Journal	Respiratory Physiology and Neurobiology
Volume	269
Early online date	23 Jul 2019
DOIs	https://doi.org/10.1016/j.resp.2019.103258
Publication status	Published - 1 Nov 2019

Keywords

Near-infrared spectroscopy
Oxygen extraction
Cycling
Exercise tolerance
Type 2 diabetes

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Rocha_InfluenceOfType2DiabetesOnMuscleDeOxygenation_Accepted_2019Accepted author manuscript, 896 KBLicence: CC BY-NC-ND

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title = "Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise",

abstract = "We tested the hypothesis that type 2 diabetes (T2D) alters the profile of muscle fractional oxygen (O2) extraction (near-infrared spectroscopy) during incremental cycle exercise. Seventeen middle-aged individuals with uncomplicated T2D and 17 controls performed an upright ramp test to exhaustion. The rate of muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration, Δ[HHb+Mb]) profiles of the vastus lateralis muscle were normalised to 100% of the response, plotted against % power output (PO) and fitted with a double linear regression model. Peak oxygen uptake was significantly (P < 0.05) reduced in individuals with T2D. The %Δ[HHb+Mb]/%PO slope of the first linear segment of the double linear regression function was significantly (P < 0.05) steeper in T2D than controls (1.81±0.61 vs 1.35±0.43). Both groups displayed a near-plateau in Δ[HHb+Mb] at an exercise intensity (%PO) not different amongst them. Such findings suggest that a reduced O2 delivery to active muscles is an important underlying cause of exercise intolerance during a maximum graded test in middle-aged individuals with T2D.",

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AU - Gildea, Norita

AU - Rocha, Joel

AU - McDermott, Adam

AU - O'Shea, Donal

AU - Green, Simon

AU - Egaña, Mikel

PY - 2019/11/1

Y1 - 2019/11/1

N2 - We tested the hypothesis that type 2 diabetes (T2D) alters the profile of muscle fractional oxygen (O2) extraction (near-infrared spectroscopy) during incremental cycle exercise. Seventeen middle-aged individuals with uncomplicated T2D and 17 controls performed an upright ramp test to exhaustion. The rate of muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration, Δ[HHb+Mb]) profiles of the vastus lateralis muscle were normalised to 100% of the response, plotted against % power output (PO) and fitted with a double linear regression model. Peak oxygen uptake was significantly (P < 0.05) reduced in individuals with T2D. The %Δ[HHb+Mb]/%PO slope of the first linear segment of the double linear regression function was significantly (P < 0.05) steeper in T2D than controls (1.81±0.61 vs 1.35±0.43). Both groups displayed a near-plateau in Δ[HHb+Mb] at an exercise intensity (%PO) not different amongst them. Such findings suggest that a reduced O2 delivery to active muscles is an important underlying cause of exercise intolerance during a maximum graded test in middle-aged individuals with T2D.

AB - We tested the hypothesis that type 2 diabetes (T2D) alters the profile of muscle fractional oxygen (O2) extraction (near-infrared spectroscopy) during incremental cycle exercise. Seventeen middle-aged individuals with uncomplicated T2D and 17 controls performed an upright ramp test to exhaustion. The rate of muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration, Δ[HHb+Mb]) profiles of the vastus lateralis muscle were normalised to 100% of the response, plotted against % power output (PO) and fitted with a double linear regression model. Peak oxygen uptake was significantly (P < 0.05) reduced in individuals with T2D. The %Δ[HHb+Mb]/%PO slope of the first linear segment of the double linear regression function was significantly (P < 0.05) steeper in T2D than controls (1.81±0.61 vs 1.35±0.43). Both groups displayed a near-plateau in Δ[HHb+Mb] at an exercise intensity (%PO) not different amongst them. Such findings suggest that a reduced O2 delivery to active muscles is an important underlying cause of exercise intolerance during a maximum graded test in middle-aged individuals with T2D.

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DO - 10.1016/j.resp.2019.103258

M3 - Article

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VL - 269

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

M1 - 103258

ER -

Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise

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