Infrared laser pulse triggers increased singlet oxygen production in tumour cells

S. G. Sokolovski, S. A. Zolotovskaya, Alexey Goltsov, C. Pourreyron, A. P. South, E. U. Rafailov

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Abstract

Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen (1O2) generation via a laser excited photosensitiser (PS) to kill cancer cells. However, prolonged sensitivity to intensive light (6–8 weeks for lung cancer), relatively low tissue penetration by activating light (630 nm up to 4 mm), and the cost of PS administration can limit progressive PDT applications. The development of quantum-dot laser diodes emitting in the highest absorption region (1268 nm) of triplet oxygen (3O2) presents the possibility of inducing apoptosis in tumour cells through direct 3O21O2 transition. Here we demonstrate that a single laser pulse triggers dose-dependent 1O2 generation in both normal keratinocytes and tumour cells and show that tumour cells yield the highest 1O2 far beyond the initial laser pulse exposure. Our modelling and experimental results support the development of direct infrared (IR) laser-induced tumour treatment as a promising approach in tumour PDT.
Original languageEnglish
Article number3484
Number of pages7
JournalScientific Reports
Volume3
DOIs
Publication statusPublished - 12 Dec 2013

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oxygen production
infrared lasers
tumors
actuators
therapy
pulses
cancer
lasers
apoptosis
oxygen
lungs
penetration
incidence
semiconductor lasers
quantum dots
costs
dosage
sensitivity

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Sokolovski, S. G., Zolotovskaya, S. A., Goltsov, A., Pourreyron, C., South, A. P., & Rafailov, E. U. (2013). Infrared laser pulse triggers increased singlet oxygen production in tumour cells. Scientific Reports, 3, [3484 ]. https://doi.org/10.1038/srep03484
Sokolovski, S. G. ; Zolotovskaya, S. A. ; Goltsov, Alexey ; Pourreyron, C. ; South, A. P. ; Rafailov, E. U. / Infrared laser pulse triggers increased singlet oxygen production in tumour cells. In: Scientific Reports. 2013 ; Vol. 3.
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Sokolovski, SG, Zolotovskaya, SA, Goltsov, A, Pourreyron, C, South, AP & Rafailov, EU 2013, 'Infrared laser pulse triggers increased singlet oxygen production in tumour cells', Scientific Reports, vol. 3, 3484 . https://doi.org/10.1038/srep03484

Infrared laser pulse triggers increased singlet oxygen production in tumour cells. / Sokolovski, S. G.; Zolotovskaya, S. A.; Goltsov, Alexey; Pourreyron, C.; South, A. P.; Rafailov, E. U.

In: Scientific Reports, Vol. 3, 3484 , 12.12.2013.

Research output: Contribution to journalArticle

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T1 - Infrared laser pulse triggers increased singlet oxygen production in tumour cells

AU - Sokolovski, S. G.

AU - Zolotovskaya, S. A.

AU - Goltsov, Alexey

AU - Pourreyron, C.

AU - South, A. P.

AU - Rafailov, E. U.

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AB - Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen (1O2) generation via a laser excited photosensitiser (PS) to kill cancer cells. However, prolonged sensitivity to intensive light (6–8 weeks for lung cancer), relatively low tissue penetration by activating light (630 nm up to 4 mm), and the cost of PS administration can limit progressive PDT applications. The development of quantum-dot laser diodes emitting in the highest absorption region (1268 nm) of triplet oxygen (3O2) presents the possibility of inducing apoptosis in tumour cells through direct 3O2 → 1O2 transition. Here we demonstrate that a single laser pulse triggers dose-dependent 1O2 generation in both normal keratinocytes and tumour cells and show that tumour cells yield the highest 1O2 far beyond the initial laser pulse exposure. Our modelling and experimental results support the development of direct infrared (IR) laser-induced tumour treatment as a promising approach in tumour PDT.

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Sokolovski SG, Zolotovskaya SA, Goltsov A, Pourreyron C, South AP, Rafailov EU. Infrared laser pulse triggers increased singlet oxygen production in tumour cells. Scientific Reports. 2013 Dec 12;3. 3484 . https://doi.org/10.1038/srep03484