Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology

O. V. Semyachkina-Glushkovskaya, S. G. Sokolovski, Alexey Goltsov, A. S. Gekaluyk, E. I. Saranceva, O. A. Bragina, V. V. Tuchin, E. U. Rafailov

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    Abstract

    For over 55 years, laser technology has expanded from laboratory research to widespread fields, for example telecommunication and data storage amongst others. Recently application of lasers in biology and medicine presents itself as one of the emerging areas. In this review, we will outline the recent advances in using lasers for the generation of singlet oxygen, traditionally used to kill tumour cells or induce thrombotic stroke model due to damage vascular effects. Over the last two decade, completely new results on cerebrovascular effects of singlet oxygen generated during photodynamic therapy (PDT) have been shown alongside promising applications for delivery of drugs and nanoparticles into the brain for therapy of brain cancer. Furthermore, a "gold key” has been found to overcome the limitations of PDT, such as low light penetration and high toxicity of photosensitizers, by direct generation of singlet oxygen using quantum-dot laser diodes emitting in the near infrared (NIR) spectral range. It is our motivation to highlight these pioneering results in this review, to improve understanding of the biological role of singlet oxygen and to provide new perspectives for improving clinical application of laser based therapy in further research.
    Original languageEnglish
    Pages (from-to)112-128
    Number of pages17
    JournalProgress in Quantum Electronics
    Volume55
    Early online date25 May 2017
    DOIs
    Publication statusPublished - Sep 2017

    Fingerprint

    Singlet Oxygen
    physiology
    Physiology
    therapy
    Photodynamic therapy
    Oxygen
    Lasers
    oxygen
    lasers
    brain
    Brain
    Quantum dot lasers
    Photosensitizing Agents
    Photosensitizers
    data storage
    Research laboratories
    strokes
    biology
    medicine
    toxicity

    Cite this

    Semyachkina-Glushkovskaya, O. V., Sokolovski, S. G., Goltsov, A., Gekaluyk, A. S., Saranceva, E. I., Bragina, O. A., ... Rafailov, E. U. (2017). Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology. Progress in Quantum Electronics, 55, 112-128. https://doi.org/10.1016/j.pquantelec.2017.05.001
    Semyachkina-Glushkovskaya, O. V. ; Sokolovski, S. G. ; Goltsov, Alexey ; Gekaluyk, A. S. ; Saranceva, E. I. ; Bragina, O. A. ; Tuchin, V. V. ; Rafailov, E. U. / Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology. In: Progress in Quantum Electronics. 2017 ; Vol. 55. pp. 112-128.
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    Semyachkina-Glushkovskaya, OV, Sokolovski, SG, Goltsov, A, Gekaluyk, AS, Saranceva, EI, Bragina, OA, Tuchin, VV & Rafailov, EU 2017, 'Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology', Progress in Quantum Electronics, vol. 55, pp. 112-128. https://doi.org/10.1016/j.pquantelec.2017.05.001

    Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology. / Semyachkina-Glushkovskaya, O. V.; Sokolovski, S. G.; Goltsov, Alexey; Gekaluyk, A. S.; Saranceva, E. I.; Bragina, O. A.; Tuchin, V. V.; Rafailov, E. U.

    In: Progress in Quantum Electronics, Vol. 55, 09.2017, p. 112-128.

    Research output: Contribution to journalArticle

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    Semyachkina-Glushkovskaya OV, Sokolovski SG, Goltsov A, Gekaluyk AS, Saranceva EI, Bragina OA et al. Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology. Progress in Quantum Electronics. 2017 Sep;55:112-128. https://doi.org/10.1016/j.pquantelec.2017.05.001