Laser light scattering applications in biotechnology

Nikolai Zhelev, S. Barudov

Research output: Contribution to journalReview article

  • 9 Citations

Abstract

Recent advancement of laser light scattering applications in biotechnology are reviewed with emphasis on their use in the biopharmaceutical industry. Light scattering methods have been used to date to characterize biomolecules in solution. They can provide information about the size and conformation of proteins and their aggregation state as well as their ability to crystallise. In addition, modern light scattering instrumentation is becoming method of choice for studying macromolecular interactions. Interactions between macromolecules such as proteins and nucleic acids mediate fundamental processes and their modulation has led to new strategies for developing therapeutics. Light scattering approaches offer significant advantage to other approaches for studying molecular interactions. Compared with other techniques, light scattering is very quick, uses minimal sample quantities, allows recovery of the sample and does nor require derivatisation.
Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalBiotechnology and Biotechnological Equipment
Volume19
Issue number3
DOIs
StatePublished - Sep 2005

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Cite this

Zhelev, Nikolai; Barudov, S. / Laser light scattering applications in biotechnology.

In: Biotechnology and Biotechnological Equipment, Vol. 19, No. 3, 09.2005, p. 3-8.

Research output: Contribution to journalReview article

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Laser light scattering applications in biotechnology. / Zhelev, Nikolai; Barudov, S.

In: Biotechnology and Biotechnological Equipment, Vol. 19, No. 3, 09.2005, p. 3-8.

Research output: Contribution to journalReview article

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AU - Zhelev,Nikolai

AU - Barudov,S.

PY - 2005/9

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DO - 10.1080/13102818.2005.10817219

M3 - Review article

VL - 19

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JO - Biotechnology and Biotechnological Equipment

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JF - Biotechnology and Biotechnological Equipment

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