Long term effects of hysterectomy on mortality

nested cohort study

Lisa Iversen, Philip C Hannaford, Alison M Elliott, Amanda J Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

OBJECTIVES: To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.

DESIGN: Nested cohort study.

SETTING: Royal College of General Practitioners' oral contraception study.

PARTICIPANTS: 7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).

MAIN OUTCOME MEASURES: Mortality from all causes, cardiovascular disease, and cancer.

RESULTS: 623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.

CONCLUSION: Hysterectomy did not increase the risk of death in the medium to long term.

Original languageEnglish
Pages (from-to)1482
JournalBMJ (Clinical research ed.)
Volume330
Issue number7506
DOIs
Publication statusPublished - 25 Jun 2005
Externally publishedYes

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Hysterectomy
Cohort Studies
Mortality
Cardiovascular Diseases
Contraception
Neoplasms
General Practitioners
Registries
Cause of Death
Confidence Intervals

Cite this

Iversen, Lisa ; Hannaford, Philip C ; Elliott, Alison M ; Lee, Amanda J. / Long term effects of hysterectomy on mortality : nested cohort study. In: BMJ (Clinical research ed.). 2005 ; Vol. 330, No. 7506. pp. 1482.
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abstract = "OBJECTIVES: To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.DESIGN: Nested cohort study.SETTING: Royal College of General Practitioners' oral contraception study.PARTICIPANTS: 7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).MAIN OUTCOME MEASURES: Mortality from all causes, cardiovascular disease, and cancer.RESULTS: 623 (8.4{\%}) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6{\%} reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95{\%} confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.CONCLUSION: Hysterectomy did not increase the risk of death in the medium to long term.",
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Long term effects of hysterectomy on mortality : nested cohort study. / Iversen, Lisa; Hannaford, Philip C; Elliott, Alison M; Lee, Amanda J.

In: BMJ (Clinical research ed.), Vol. 330, No. 7506, 25.06.2005, p. 1482.

Research output: Contribution to journalArticle

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AU - Iversen, Lisa

AU - Hannaford, Philip C

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AU - Lee, Amanda J

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N2 - OBJECTIVES: To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.DESIGN: Nested cohort study.SETTING: Royal College of General Practitioners' oral contraception study.PARTICIPANTS: 7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).MAIN OUTCOME MEASURES: Mortality from all causes, cardiovascular disease, and cancer.RESULTS: 623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.CONCLUSION: Hysterectomy did not increase the risk of death in the medium to long term.

AB - OBJECTIVES: To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.DESIGN: Nested cohort study.SETTING: Royal College of General Practitioners' oral contraception study.PARTICIPANTS: 7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).MAIN OUTCOME MEASURES: Mortality from all causes, cardiovascular disease, and cancer.RESULTS: 623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.CONCLUSION: Hysterectomy did not increase the risk of death in the medium to long term.

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