Abstract
OBJECTIVES: To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.
DESIGN: Nested cohort study.
SETTING: Royal College of General Practitioners' oral contraception study.
PARTICIPANTS: 7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).
MAIN OUTCOME MEASURES: Mortality from all causes, cardiovascular disease, and cancer.
RESULTS: 623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.
CONCLUSION: Hysterectomy did not increase the risk of death in the medium to long term.
| Original language | English |
|---|---|
| Pages (from-to) | 1482 |
| Journal | BMJ (Clinical research ed.) |
| Volume | 330 |
| Issue number | 7506 |
| DOIs | |
| Publication status | Published - 25 Jun 2005 |
| Externally published | Yes |
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Long term effects of hysterectomy on mortality : nested cohort study. / Iversen, Lisa; Hannaford, Philip C; Elliott, Alison M; Lee, Amanda J.
In: BMJ (Clinical research ed.), Vol. 330, No. 7506, 25.06.2005, p. 1482.Research output: Contribution to journal › Article
TY - JOUR
T1 - Long term effects of hysterectomy on mortality
T2 - nested cohort study
AU - Iversen, Lisa
AU - Hannaford, Philip C
AU - Elliott, Alison M
AU - Lee, Amanda J
PY - 2005/6/25
Y1 - 2005/6/25
N2 - OBJECTIVES: To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.DESIGN: Nested cohort study.SETTING: Royal College of General Practitioners' oral contraception study.PARTICIPANTS: 7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).MAIN OUTCOME MEASURES: Mortality from all causes, cardiovascular disease, and cancer.RESULTS: 623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.CONCLUSION: Hysterectomy did not increase the risk of death in the medium to long term.
AB - OBJECTIVES: To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.DESIGN: Nested cohort study.SETTING: Royal College of General Practitioners' oral contraception study.PARTICIPANTS: 7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).MAIN OUTCOME MEASURES: Mortality from all causes, cardiovascular disease, and cancer.RESULTS: 623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.CONCLUSION: Hysterectomy did not increase the risk of death in the medium to long term.
U2 - 10.1136/bmj.38483.669178.8F
DO - 10.1136/bmj.38483.669178.8F
M3 - Article
C2 - 15930026
VL - 330
SP - 1482
JO - BMJ (Clinical research ed.)
JF - BMJ (Clinical research ed.)
SN - 0267-0623
IS - 7506
ER -