Long term effects of hysterectomy on mortality: nested cohort study

Lisa Iversen; Philip C Hannaford; Alison M Elliott; Amanda J Lee

doi:10.1136/bmj.38483.669178.8F

Long term effects of hysterectomy on mortality: nested cohort study

Lisa Iversen, Philip C Hannaford, Alison M Elliott, Amanda J Lee

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Abstract

OBJECTIVES: To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.

DESIGN: Nested cohort study.

SETTING: Royal College of General Practitioners' oral contraception study.

PARTICIPANTS: 7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).

MAIN OUTCOME MEASURES: Mortality from all causes, cardiovascular disease, and cancer.

RESULTS: 623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.

CONCLUSION: Hysterectomy did not increase the risk of death in the medium to long term.

Original language	English
Pages (from-to)	1482
Journal	BMJ (Clinical research ed.)
Volume	330
Issue number	7506
DOIs	https://doi.org/10.1136/bmj.38483.669178.8F
Publication status	Published - 25 Jun 2005
Externally published	Yes

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Iversen, L., Hannaford, P. C., Elliott, A. M., & Lee, A. J. (2005). Long term effects of hysterectomy on mortality: nested cohort study. BMJ (Clinical research ed.), 330(7506), 1482. https://doi.org/10.1136/bmj.38483.669178.8F

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title = "Long term effects of hysterectomy on mortality: nested cohort study",

abstract = "OBJECTIVES: To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.DESIGN: Nested cohort study.SETTING: Royal College of General Practitioners' oral contraception study.PARTICIPANTS: 7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).MAIN OUTCOME MEASURES: Mortality from all causes, cardiovascular disease, and cancer.RESULTS: 623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.CONCLUSION: Hysterectomy did not increase the risk of death in the medium to long term.",

author = "Lisa Iversen and Hannaford, {Philip C} and Elliott, {Alison M} and Lee, {Amanda J}",

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T1 - Long term effects of hysterectomy on mortality

T2 - nested cohort study

AU - Iversen, Lisa

AU - Hannaford, Philip C

AU - Elliott, Alison M

AU - Lee, Amanda J

PY - 2005/6/25

Y1 - 2005/6/25

N2 - OBJECTIVES: To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.DESIGN: Nested cohort study.SETTING: Royal College of General Practitioners' oral contraception study.PARTICIPANTS: 7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).MAIN OUTCOME MEASURES: Mortality from all causes, cardiovascular disease, and cancer.RESULTS: 623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.CONCLUSION: Hysterectomy did not increase the risk of death in the medium to long term.

AB - OBJECTIVES: To investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.DESIGN: Nested cohort study.SETTING: Royal College of General Practitioners' oral contraception study.PARTICIPANTS: 7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).MAIN OUTCOME MEASURES: Mortality from all causes, cardiovascular disease, and cancer.RESULTS: 623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.CONCLUSION: Hysterectomy did not increase the risk of death in the medium to long term.

U2 - 10.1136/bmj.38483.669178.8F

DO - 10.1136/bmj.38483.669178.8F

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JO - BMJ (Clinical research ed.)

JF - BMJ (Clinical research ed.)

SN - 0267-0623

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