Low-volume HIIT and MICT speed V̇O2 kinetics during high-intensity "work-to-work" cycling with a similar time-course in type 2 diabetes

Norita Gildea, Adam McDermott, Joel Rocha, Domenico Crognale, Aaron Nevin, Donal O'Shea, Simon Green, Mikel Egaña*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We assessed the rates of adjustment in oxygen uptake (V̇O2) and muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) during the on-transition to high-intensity cycling initiated from an elevated baseline (work-to-work) before training and at weeks 3, 6, 9 and 12 of low-volume high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) in type 2 diabetes (T2D). Participants were randomly assigned to MICT (n=11, 50 min of moderate-intensity cycling), HIIT (n =8, 10x1 min of high-intensity cycling separated by 1-min of light cycling) or non-exercising control (n=9) groups. Exercising groups trained 3 times per week. Participants completed two work-to-work transitions at each time point consisting of sequential step increments to moderate- and high-intensity work-rates. [HHb+Mb] kinetics were measured by near-infrared spectroscopy at the vastus lateralis muscle. The pretraining time constant of the primary phase of V̇O2 (V̇O2τp) and the amplitude of the V̇O2 slow component (V̇O2As) of the high-intensity w-to-w bout decreased (P<0.05) by a similar magnitude at wk 3 of training in both MICT (from, 56±9 to 43±6s, and from 0.17±0.07 to 0.09±0.05 L.min-1, respectively) and HIIT (from, 56±8 to 42±6s, and from 0.18±0.05 to 0.09±0.08 L.min-1, respectively) with no further changes thereafter. No changes were reported in controls. The parameter estimates of Δ[HHb+Mb] remained unchanged in all groups. MICT and HIIT elicited comparable improvements in V̇O2 kinetics without changes in muscle deoxygenation kinetics during high-intensity exercise initiated from an elevated baseline in T2D despite training volume and time commitment being ~50% lower in the HIIT group.
Original languageEnglish
JournalJournal of Applied Physiology
Early online date9 Jun 2022
Publication statusE-pub ahead of print - 9 Jun 2022


  • Exercise transitions
  • Near-infrared spectroscopy
  • Oxygen extraction
  • Exercise tolerance
  • Oxygen uptake slow component

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