Magnesium and cell cycle control: an update

Research output: Contribution to journalArticle

  • 62 Citations

Abstract

Accumulating evidence, from bacteria to human cells, points to a universal role for magnesium in controlling the cell cycle. In microorganisms, the co-ordinate sequence of events which culminate in biomass doubling and cell division may be modulated through expression of differential magnesium effects during the cell cycle. For example, it has been suggested in bacteria that growth and cell division may possess different affinities for magnesium; whilst in yeast, cell cycle-dependent fluxes in intracellular magnesium are postulated to regulate cell proliferation. In mammalian cells, magnesium is important in governing key rate-limiting steps in the cell cycle, particularly at the onset of DNA synthesis and at mitosis. Furthermore, it has been demonstrated that cell transformation may cause selective loss of this regulatory role for magnesium, implying that magnesium is important in oncogenesis and perhaps in the expression of malignancy.
Original languageEnglish
Pages (from-to)9-23
Number of pages15
JournalMagnesium
Volume5
Issue number1
StatePublished - 1986

Fingerprint

Cell Cycle Checkpoints
Magnesium
Cell Cycle
Cell Division
Bacteria
Mitosis
Biomass
Carcinogenesis
Yeasts
Cell Proliferation
DNA

Cite this

Walker, Graeme M. / Magnesium and cell cycle control : an update.

In: Magnesium, Vol. 5, No. 1, 1986, p. 9-23.

Research output: Contribution to journalArticle

@article{a4a5cf8b383c4863b272c67daf373e6c,
title = "Magnesium and cell cycle control: an update",
abstract = "Accumulating evidence, from bacteria to human cells, points to a universal role for magnesium in controlling the cell cycle. In microorganisms, the co-ordinate sequence of events which culminate in biomass doubling and cell division may be modulated through expression of differential magnesium effects during the cell cycle. For example, it has been suggested in bacteria that growth and cell division may possess different affinities for magnesium; whilst in yeast, cell cycle-dependent fluxes in intracellular magnesium are postulated to regulate cell proliferation. In mammalian cells, magnesium is important in governing key rate-limiting steps in the cell cycle, particularly at the onset of DNA synthesis and at mitosis. Furthermore, it has been demonstrated that cell transformation may cause selective loss of this regulatory role for magnesium, implying that magnesium is important in oncogenesis and perhaps in the expression of malignancy.",
author = "Walker, {Graeme M.}",
year = "1986",
volume = "5",
pages = "9--23",
journal = "Magnesium",
issn = "0252-1156",
number = "1",

}

Magnesium and cell cycle control : an update. / Walker, Graeme M.

In: Magnesium, Vol. 5, No. 1, 1986, p. 9-23.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Magnesium and cell cycle control

T2 - Magnesium

AU - Walker,Graeme M.

PY - 1986

Y1 - 1986

N2 - Accumulating evidence, from bacteria to human cells, points to a universal role for magnesium in controlling the cell cycle. In microorganisms, the co-ordinate sequence of events which culminate in biomass doubling and cell division may be modulated through expression of differential magnesium effects during the cell cycle. For example, it has been suggested in bacteria that growth and cell division may possess different affinities for magnesium; whilst in yeast, cell cycle-dependent fluxes in intracellular magnesium are postulated to regulate cell proliferation. In mammalian cells, magnesium is important in governing key rate-limiting steps in the cell cycle, particularly at the onset of DNA synthesis and at mitosis. Furthermore, it has been demonstrated that cell transformation may cause selective loss of this regulatory role for magnesium, implying that magnesium is important in oncogenesis and perhaps in the expression of malignancy.

AB - Accumulating evidence, from bacteria to human cells, points to a universal role for magnesium in controlling the cell cycle. In microorganisms, the co-ordinate sequence of events which culminate in biomass doubling and cell division may be modulated through expression of differential magnesium effects during the cell cycle. For example, it has been suggested in bacteria that growth and cell division may possess different affinities for magnesium; whilst in yeast, cell cycle-dependent fluxes in intracellular magnesium are postulated to regulate cell proliferation. In mammalian cells, magnesium is important in governing key rate-limiting steps in the cell cycle, particularly at the onset of DNA synthesis and at mitosis. Furthermore, it has been demonstrated that cell transformation may cause selective loss of this regulatory role for magnesium, implying that magnesium is important in oncogenesis and perhaps in the expression of malignancy.

M3 - Article

VL - 5

SP - 9

EP - 23

JO - Magnesium

JF - Magnesium

SN - 0252-1156

IS - 1

ER -