Magnesium and the regulation of germ-tube formation in Candida albicans

Graeme M. Walker, Patrick A. Sullivan, Maxwell G. Shepherd

Research output: Contribution to journalArticle

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Abstract

Candida albicans requires Mg2+ for germ-tube formation. Mg-deficient media, metal ion chelators and the ionophore A23187 inhibited germ-tube formation. Cell Mg content during exponential yeast-phase growth remained constant but increased throughout germ-tube formation. The onset of germ-tube formation coincided with a sharp peak in Mg concentration within the cells. Yeast-phase cells of strain CA2, which did not form germ-tubes, had a lower Mg content and failed to accumulate Mg when incubated under conditions for germ-tube formation. Mg also increased the uptake and incorporation of N-acetylglucosamine. These findings point to a central regulatory role for Mg in C. albicans morphogenesis.
Original languageEnglish
Pages (from-to)1941-1945
Number of pages5
JournalJournal of General Microbiology
Volume130
Issue number8
DOIs
StatePublished - 1 Aug 1984

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Candida albicans
Magnesium
Yeasts
Acetylglucosamine
Ionophores
Calcimycin
Chelating Agents
Morphogenesis
Metals
Ions

Cite this

Walker, Graeme M.; Sullivan, Patrick A.; Shepherd, Maxwell G. / Magnesium and the regulation of germ-tube formation in Candida albicans.

In: Journal of General Microbiology, Vol. 130, No. 8, 01.08.1984, p. 1941-1945.

Research output: Contribution to journalArticle

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Magnesium and the regulation of germ-tube formation in Candida albicans. / Walker, Graeme M.; Sullivan, Patrick A.; Shepherd, Maxwell G.

In: Journal of General Microbiology, Vol. 130, No. 8, 01.08.1984, p. 1941-1945.

Research output: Contribution to journalArticle

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AB - Candida albicans requires Mg2+ for germ-tube formation. Mg-deficient media, metal ion chelators and the ionophore A23187 inhibited germ-tube formation. Cell Mg content during exponential yeast-phase growth remained constant but increased throughout germ-tube formation. The onset of germ-tube formation coincided with a sharp peak in Mg concentration within the cells. Yeast-phase cells of strain CA2, which did not form germ-tubes, had a lower Mg content and failed to accumulate Mg when incubated under conditions for germ-tube formation. Mg also increased the uptake and incorporation of N-acetylglucosamine. These findings point to a central regulatory role for Mg in C. albicans morphogenesis.

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