Magnesium as the fundamental regulator of the cell cycle

Graeme M. Walker, John H. Duffus

    Research output: Contribution to journalArticle

    Abstract

    A hypothesis to account for the regulation of the eukaryotic cell cycle has been formulated in which free magnesium concentration acts as the fundamental transducer of cell size that correlates cell growth to mitosis and division. It is proposed that intracellular magnesium levels control the timing of spindle and chromosome cycles by varying periodically during the cell cycle. Thus, a gradual, volume-related fall in magnesium concentration during interphase which is terminated by rapid, transient fluxes at mitosis, is postulated to be necessary for triggering both microtubule breakdown and chromosome condensation. This general scheme, originally developed for the fission yeast, Schizosaccharomyces pombe, can be applied to higher cell division (including tumour cells) by assigning a central regulatory role for magnesium. For example, magnesium availability can be shown to form the mechanistic basis of many theoretical cell cycle models, and can also explain the effects of many proposed cell cycle regulators, including calcium and cyclic AMP.
    Original languageEnglish
    Pages (from-to)1-16
    Number of pages16
    JournalMagnesium
    Volume2
    Publication statusPublished - 1983

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    cell cycle
    magnesium
    Schizosaccharomyces pombe
    mitosis
    chromosomes
    cyclic AMP
    interphase
    microtubules
    eukaryotic cells
    cell division
    cell growth
    calcium
    cells

    Cite this

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    title = "Magnesium as the fundamental regulator of the cell cycle",
    abstract = "A hypothesis to account for the regulation of the eukaryotic cell cycle has been formulated in which free magnesium concentration acts as the fundamental transducer of cell size that correlates cell growth to mitosis and division. It is proposed that intracellular magnesium levels control the timing of spindle and chromosome cycles by varying periodically during the cell cycle. Thus, a gradual, volume-related fall in magnesium concentration during interphase which is terminated by rapid, transient fluxes at mitosis, is postulated to be necessary for triggering both microtubule breakdown and chromosome condensation. This general scheme, originally developed for the fission yeast, Schizosaccharomyces pombe, can be applied to higher cell division (including tumour cells) by assigning a central regulatory role for magnesium. For example, magnesium availability can be shown to form the mechanistic basis of many theoretical cell cycle models, and can also explain the effects of many proposed cell cycle regulators, including calcium and cyclic AMP.",
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    year = "1983",
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    Magnesium as the fundamental regulator of the cell cycle. / Walker, Graeme M.; Duffus, John H.

    In: Magnesium, Vol. 2, 1983, p. 1-16.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Magnesium as the fundamental regulator of the cell cycle

    AU - Walker, Graeme M.

    AU - Duffus, John H.

    PY - 1983

    Y1 - 1983

    N2 - A hypothesis to account for the regulation of the eukaryotic cell cycle has been formulated in which free magnesium concentration acts as the fundamental transducer of cell size that correlates cell growth to mitosis and division. It is proposed that intracellular magnesium levels control the timing of spindle and chromosome cycles by varying periodically during the cell cycle. Thus, a gradual, volume-related fall in magnesium concentration during interphase which is terminated by rapid, transient fluxes at mitosis, is postulated to be necessary for triggering both microtubule breakdown and chromosome condensation. This general scheme, originally developed for the fission yeast, Schizosaccharomyces pombe, can be applied to higher cell division (including tumour cells) by assigning a central regulatory role for magnesium. For example, magnesium availability can be shown to form the mechanistic basis of many theoretical cell cycle models, and can also explain the effects of many proposed cell cycle regulators, including calcium and cyclic AMP.

    AB - A hypothesis to account for the regulation of the eukaryotic cell cycle has been formulated in which free magnesium concentration acts as the fundamental transducer of cell size that correlates cell growth to mitosis and division. It is proposed that intracellular magnesium levels control the timing of spindle and chromosome cycles by varying periodically during the cell cycle. Thus, a gradual, volume-related fall in magnesium concentration during interphase which is terminated by rapid, transient fluxes at mitosis, is postulated to be necessary for triggering both microtubule breakdown and chromosome condensation. This general scheme, originally developed for the fission yeast, Schizosaccharomyces pombe, can be applied to higher cell division (including tumour cells) by assigning a central regulatory role for magnesium. For example, magnesium availability can be shown to form the mechanistic basis of many theoretical cell cycle models, and can also explain the effects of many proposed cell cycle regulators, including calcium and cyclic AMP.

    M3 - Article

    VL - 2

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    EP - 16

    JO - Magnesium

    JF - Magnesium

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