Microemulsions are highly effective anti-biofilm agents

I. S. I. Al-Adham, N. D. Al-Hmoud, Enam Khalil, M. Kierans, Phillip J. Collier

Research output: Contribution to journalArticle

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Abstract

Aims: The demonstration of the antibiofilm effects of pharmaceutical microemulsions.
Methods and Results: Microemulsions were prepared as physically stable oil/water systems. Previous work by this group has shown that microemulsions are highly effective antimembrane agents that result in rapid losses of viability in planktonic populations of Pseudomonas aeruginosa and Staphylococcus aureus. In this experiment a microemulsion preparation was used upon established biofilm cultures of Ps. aeruginosa PA01 for a period of 4 h. The planktonic MIC of sodium pyrithione and the planktonic and biofilm MICs of cetrimide were used as positive controls and a biofilm was exposed to a volume of normal sterile saline as a treatment (negative) control. Results indicate three log-cycle reductions in viability within the microemulsion treated biofilm, as compared to those observed in control treatments of similar biofilms (one log-cycle reduction in viabilities).
Conclusions: The results indicate that the microemulsions are highly effective antibiofilm agents.
Significance and Impact of the Study: This study suggests that microemulsions may have a role in the treatment of industrial and environmental biofilms.
Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalLetters in Applied Microbiology
Volume36
Issue number2
DOIs
StatePublished - Feb 2003

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Biofilms
Pseudomonas aeruginosa
Staphylococcus aureus
Oils
Sodium
Water

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Al-Adham, I. S. I., Al-Hmoud, N. D., Khalil, E., Kierans, M., & Collier, P. J. (2003). Microemulsions are highly effective anti-biofilm agents. Letters in Applied Microbiology, 36(2), 97-100. DOI: 10.1046/j.1472-765X.2003.01266.x

Al-Adham, I. S. I.; Al-Hmoud, N. D.; Khalil, Enam; Kierans, M.; Collier, Phillip J. / Microemulsions are highly effective anti-biofilm agents.

In: Letters in Applied Microbiology, Vol. 36, No. 2, 02.2003, p. 97-100.

Research output: Contribution to journalArticle

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abstract = "Aims: The demonstration of the antibiofilm effects of pharmaceutical microemulsions.Methods and Results: Microemulsions were prepared as physically stable oil/water systems. Previous work by this group has shown that microemulsions are highly effective antimembrane agents that result in rapid losses of viability in planktonic populations of Pseudomonas aeruginosa and Staphylococcus aureus. In this experiment a microemulsion preparation was used upon established biofilm cultures of Ps. aeruginosa PA01 for a period of 4 h. The planktonic MIC of sodium pyrithione and the planktonic and biofilm MICs of cetrimide were used as positive controls and a biofilm was exposed to a volume of normal sterile saline as a treatment (negative) control. Results indicate three log-cycle reductions in viability within the microemulsion treated biofilm, as compared to those observed in control treatments of similar biofilms (one log-cycle reduction in viabilities).Conclusions: The results indicate that the microemulsions are highly effective antibiofilm agents.Significance and Impact of the Study: This study suggests that microemulsions may have a role in the treatment of industrial and environmental biofilms.",
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Al-Adham, ISI, Al-Hmoud, ND, Khalil, E, Kierans, M & Collier, PJ 2003, 'Microemulsions are highly effective anti-biofilm agents' Letters in Applied Microbiology, vol 36, no. 2, pp. 97-100. DOI: 10.1046/j.1472-765X.2003.01266.x

Microemulsions are highly effective anti-biofilm agents. / Al-Adham, I. S. I.; Al-Hmoud, N. D.; Khalil, Enam; Kierans, M.; Collier, Phillip J.

In: Letters in Applied Microbiology, Vol. 36, No. 2, 02.2003, p. 97-100.

Research output: Contribution to journalArticle

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AU - Al-Adham,I. S. I.

AU - Al-Hmoud,N. D.

AU - Khalil,Enam

AU - Kierans,M.

AU - Collier,Phillip J.

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AB - Aims: The demonstration of the antibiofilm effects of pharmaceutical microemulsions.Methods and Results: Microemulsions were prepared as physically stable oil/water systems. Previous work by this group has shown that microemulsions are highly effective antimembrane agents that result in rapid losses of viability in planktonic populations of Pseudomonas aeruginosa and Staphylococcus aureus. In this experiment a microemulsion preparation was used upon established biofilm cultures of Ps. aeruginosa PA01 for a period of 4 h. The planktonic MIC of sodium pyrithione and the planktonic and biofilm MICs of cetrimide were used as positive controls and a biofilm was exposed to a volume of normal sterile saline as a treatment (negative) control. Results indicate three log-cycle reductions in viability within the microemulsion treated biofilm, as compared to those observed in control treatments of similar biofilms (one log-cycle reduction in viabilities).Conclusions: The results indicate that the microemulsions are highly effective antibiofilm agents.Significance and Impact of the Study: This study suggests that microemulsions may have a role in the treatment of industrial and environmental biofilms.

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Al-Adham ISI, Al-Hmoud ND, Khalil E, Kierans M, Collier PJ. Microemulsions are highly effective anti-biofilm agents. Letters in Applied Microbiology. 2003 Feb;36(2):97-100. Available from, DOI: 10.1046/j.1472-765X.2003.01266.x