Molecular modelling of the 5-hydroxytryptamine receptors

G. Wishart*, D. H. Bremner, K. R. Sturrock

*Corresponding author for this work

    Research output: Contribution to journalReview article

    10 Citations (Scopus)

    Abstract

    Molecular models of the 5-hydroxytryptamine receptors are reviewed with particular emphasis upon ligand receptor interactions. The use of such models in the areas of drug design and the design and rationalisation of experiments is discussed. It is clear that many groups have modelled the 5-HT receptors using either the bacteriorhodopsin structure, rhodopsin electron density map or rhodopsin α-carbon template. Although it is difficult to assess the accuracy of these models it is expected that the rhodopsin based models show improved accuracy over the bacteriorhodopsin based models. Nevertheless models that are thoroughly validated with experimental mutagenesis and ligand binding data are useful in a qualitative sense providing ideas upon target compounds to synthesise and the design and rationalisation of mutagenesis experiments.

    Original languageEnglish
    Pages (from-to)317-335
    Number of pages19
    JournalReceptors and Channels
    Volume6
    Issue number4
    Publication statusPublished - 27 Jul 1999

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    Rhodopsin
    Serotonin Receptors
    Bacteriorhodopsins
    Mutagenesis
    Ligands
    Molecular Models
    Drug Design
    Carbon
    Electrons

    Cite this

    Wishart, G. ; Bremner, D. H. ; Sturrock, K. R. / Molecular modelling of the 5-hydroxytryptamine receptors. In: Receptors and Channels. 1999 ; Vol. 6, No. 4. pp. 317-335.
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    title = "Molecular modelling of the 5-hydroxytryptamine receptors",
    abstract = "Molecular models of the 5-hydroxytryptamine receptors are reviewed with particular emphasis upon ligand receptor interactions. The use of such models in the areas of drug design and the design and rationalisation of experiments is discussed. It is clear that many groups have modelled the 5-HT receptors using either the bacteriorhodopsin structure, rhodopsin electron density map or rhodopsin α-carbon template. Although it is difficult to assess the accuracy of these models it is expected that the rhodopsin based models show improved accuracy over the bacteriorhodopsin based models. Nevertheless models that are thoroughly validated with experimental mutagenesis and ligand binding data are useful in a qualitative sense providing ideas upon target compounds to synthesise and the design and rationalisation of mutagenesis experiments.",
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    Wishart, G, Bremner, DH & Sturrock, KR 1999, 'Molecular modelling of the 5-hydroxytryptamine receptors', Receptors and Channels, vol. 6, no. 4, pp. 317-335.

    Molecular modelling of the 5-hydroxytryptamine receptors. / Wishart, G.; Bremner, D. H.; Sturrock, K. R.

    In: Receptors and Channels, Vol. 6, No. 4, 27.07.1999, p. 317-335.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Molecular modelling of the 5-hydroxytryptamine receptors

    AU - Wishart, G.

    AU - Bremner, D. H.

    AU - Sturrock, K. R.

    PY - 1999/7/27

    Y1 - 1999/7/27

    N2 - Molecular models of the 5-hydroxytryptamine receptors are reviewed with particular emphasis upon ligand receptor interactions. The use of such models in the areas of drug design and the design and rationalisation of experiments is discussed. It is clear that many groups have modelled the 5-HT receptors using either the bacteriorhodopsin structure, rhodopsin electron density map or rhodopsin α-carbon template. Although it is difficult to assess the accuracy of these models it is expected that the rhodopsin based models show improved accuracy over the bacteriorhodopsin based models. Nevertheless models that are thoroughly validated with experimental mutagenesis and ligand binding data are useful in a qualitative sense providing ideas upon target compounds to synthesise and the design and rationalisation of mutagenesis experiments.

    AB - Molecular models of the 5-hydroxytryptamine receptors are reviewed with particular emphasis upon ligand receptor interactions. The use of such models in the areas of drug design and the design and rationalisation of experiments is discussed. It is clear that many groups have modelled the 5-HT receptors using either the bacteriorhodopsin structure, rhodopsin electron density map or rhodopsin α-carbon template. Although it is difficult to assess the accuracy of these models it is expected that the rhodopsin based models show improved accuracy over the bacteriorhodopsin based models. Nevertheless models that are thoroughly validated with experimental mutagenesis and ligand binding data are useful in a qualitative sense providing ideas upon target compounds to synthesise and the design and rationalisation of mutagenesis experiments.

    M3 - Review article

    C2 - 10412724

    AN - SCOPUS:0032800309

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    JO - Receptors and Channels

    JF - Receptors and Channels

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