Monoclonal antibody to a nucleolar antigen of human B-lymphoblastoid cells

I. T. Todorov; R. N. Philipova; N. Z. Zhelev; A. A. Hadjiolov

doi:10.1016/0309-1651(87)90024-5

Monoclonal antibody to a nucleolar antigen of human B-lymphoblastoid cells

I. T. Todorov^*
, R. N. Philipova
, N. Z. Zhelev
, A. A. Hadjiolov

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

An anti-nucleolar monoclonal antibody reacting with human B-lymphoblastoid cells but not with normal periferal blood lymphocytes has been isolated. The antibody recognized in Namalwa cells an antigen with molecular mass 41 kDa and pI 5.6, different from all previously described nucleolar antigens. Inhibition of rRNA transcription with Actinomycin D caused redistribution of the 41 5.6 antigen, but even at long term drug action it remains associated with the nucleolar remnants.

Original language	English
Pages (from-to)	181-187
Number of pages	7
Journal	Cell Biology International Reports
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0309-1651(87)90024-5
Publication status	Published - Mar 1987
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1016/0309-1651(87)90024-5

Cite this

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title = "Monoclonal antibody to a nucleolar antigen of human B-lymphoblastoid cells",

abstract = "An anti-nucleolar monoclonal antibody reacting with human B-lymphoblastoid cells but not with normal periferal blood lymphocytes has been isolated. The antibody recognized in Namalwa cells an antigen with molecular mass 41 kDa and pI 5.6, different from all previously described nucleolar antigens. Inhibition of rRNA transcription with Actinomycin D caused redistribution of the 41 5.6 antigen, but even at long term drug action it remains associated with the nucleolar remnants.",

author = "Todorov, \{I. T.\} and Philipova, \{R. N.\} and Zhelev, \{N. Z.\} and Hadjiolov, \{A. A.\}",

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AU - Todorov, I. T.

AU - Philipova, R. N.

AU - Zhelev, N. Z.

AU - Hadjiolov, A. A.

PY - 1987/3

Y1 - 1987/3

N2 - An anti-nucleolar monoclonal antibody reacting with human B-lymphoblastoid cells but not with normal periferal blood lymphocytes has been isolated. The antibody recognized in Namalwa cells an antigen with molecular mass 41 kDa and pI 5.6, different from all previously described nucleolar antigens. Inhibition of rRNA transcription with Actinomycin D caused redistribution of the 41 5.6 antigen, but even at long term drug action it remains associated with the nucleolar remnants.

AB - An anti-nucleolar monoclonal antibody reacting with human B-lymphoblastoid cells but not with normal periferal blood lymphocytes has been isolated. The antibody recognized in Namalwa cells an antigen with molecular mass 41 kDa and pI 5.6, different from all previously described nucleolar antigens. Inhibition of rRNA transcription with Actinomycin D caused redistribution of the 41 5.6 antigen, but even at long term drug action it remains associated with the nucleolar remnants.

U2 - 10.1016/0309-1651(87)90024-5

DO - 10.1016/0309-1651(87)90024-5

M3 - Article

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AN - SCOPUS:0023296573

SN - 0309-1651

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SP - 181

EP - 187

JO - Cell Biology International Reports

JF - Cell Biology International Reports

IS - 3

ER -

Monoclonal antibody to a nucleolar antigen of human B-lymphoblastoid cells

Abstract

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