Multifunctional A7R peptide-modified hollow mesoporous silica@Ag2S nanotheranostics for photoacoustic/near-infrared fluorescence imaging-guided tumor-targeted chemo-photothermal therapy

Jianrong Wu, David H. Bremner, Shiwei Niu, Dejian Li, Ranran Tang, Li Min Zhu*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    Abstract

    The fabrication of theranostic nanoplatforms which combine diagnostic and therapeutic functions have become an emerging approach for personal nanomedicine. Herein, a multifunctional nanoplatform consisting of A7R peptide (ATWLPPR) conjugated hollow mesoporous silica nanoparticles decorated with Ag2S nanodots (Ag2S@HMSs-A7R) has been developed as an efficient theranostic agent for simultaneous photoacoustic (PA) imaging and near-infrared fluorescence imaging (NIRF)-guided targeted chemotherapy and photothermal therapy against human breast cancer MDA-MB-231 cells. The design of Ag2S doped HMSs by in situ controlled growth of ultrasmall Ag2S nanodots in the mesopores of HMSs. The synthesized multifunctional nanoplatform exhibits high doxorubicin (DOX) loading capability (451 mg/g) and can be precisely controlled by glutathione (GSH), acidic environment and external laser irradiation. Thanks to the strong tunable NIR absorbance of Ag2S, the nanoplatform produce effective photoacoustic capacity and superb photothermal conversion under light irradiation, thereby exhibiting sufficient in vivo fluorescence and photoacoustic signals as well as desirable photothermal therapeutic performance. Importantly, A7R peptide can selectively bind the Neuropilin-1 (NRP-1) receptor which overexpressed by the MDA-MB-231 cells. The achieved Ag2S@HMSs-A7R possess ideal imaging capability for both PA and NIRF imaging in vivo, and the anti-tumor effect of Ag2S@HMSs(DOX)-A7R was studied in vitro and in vivo, showing remarkable synergistic chemo-photothermal effect (combination index, CI < 1). Over all, the strategy of utilizing triple-responsive nanocarriers presents a highly promising potential as an efficient method for cancer theranostics.

    Original languageEnglish
    Pages (from-to)1415-1431
    Number of pages17
    JournalJournal of Biomedical Nanotechnology
    Volume15
    Issue number7
    DOIs
    Publication statusPublished - 1 Jul 2019

    Fingerprint

    Chemotherapy
    Photoacoustic effect
    Optical Imaging
    Silicon Dioxide
    Peptides
    Tumors
    Fluorescence
    Silica
    Infrared radiation
    Imaging techniques
    Doxorubicin
    Neuropilin-1
    Nanomedicine
    Neoplasms
    Nanoparticles
    Glutathione
    Lasers
    Medical nanotechnology
    Therapeutics
    Breast Neoplasms

    Cite this

    @article{57fb88d77f3d45b483a3ccd53f5f3a54,
    title = "Multifunctional A7R peptide-modified hollow mesoporous silica@Ag2S nanotheranostics for photoacoustic/near-infrared fluorescence imaging-guided tumor-targeted chemo-photothermal therapy",
    abstract = "The fabrication of theranostic nanoplatforms which combine diagnostic and therapeutic functions have become an emerging approach for personal nanomedicine. Herein, a multifunctional nanoplatform consisting of A7R peptide (ATWLPPR) conjugated hollow mesoporous silica nanoparticles decorated with Ag2S nanodots (Ag2S@HMSs-A7R) has been developed as an efficient theranostic agent for simultaneous photoacoustic (PA) imaging and near-infrared fluorescence imaging (NIRF)-guided targeted chemotherapy and photothermal therapy against human breast cancer MDA-MB-231 cells. The design of Ag2S doped HMSs by in situ controlled growth of ultrasmall Ag2S nanodots in the mesopores of HMSs. The synthesized multifunctional nanoplatform exhibits high doxorubicin (DOX) loading capability (451 mg/g) and can be precisely controlled by glutathione (GSH), acidic environment and external laser irradiation. Thanks to the strong tunable NIR absorbance of Ag2S, the nanoplatform produce effective photoacoustic capacity and superb photothermal conversion under light irradiation, thereby exhibiting sufficient in vivo fluorescence and photoacoustic signals as well as desirable photothermal therapeutic performance. Importantly, A7R peptide can selectively bind the Neuropilin-1 (NRP-1) receptor which overexpressed by the MDA-MB-231 cells. The achieved Ag2S@HMSs-A7R possess ideal imaging capability for both PA and NIRF imaging in vivo, and the anti-tumor effect of Ag2S@HMSs(DOX)-A7R was studied in vitro and in vivo, showing remarkable synergistic chemo-photothermal effect (combination index, CI < 1). Over all, the strategy of utilizing triple-responsive nanocarriers presents a highly promising potential as an efficient method for cancer theranostics.",
    author = "Jianrong Wu and Bremner, {David H.} and Shiwei Niu and Dejian Li and Ranran Tang and Zhu, {Li Min}",
    year = "2019",
    month = "7",
    day = "1",
    doi = "10.1166/jbn.2019.2729",
    language = "English",
    volume = "15",
    pages = "1415--1431",
    journal = "Journal of Biomedical Nanotechnology",
    issn = "1550-7033",
    publisher = "American Scientific Publishers",
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    }

    Multifunctional A7R peptide-modified hollow mesoporous silica@Ag2S nanotheranostics for photoacoustic/near-infrared fluorescence imaging-guided tumor-targeted chemo-photothermal therapy. / Wu, Jianrong; Bremner, David H.; Niu, Shiwei; Li, Dejian; Tang, Ranran; Zhu, Li Min.

    In: Journal of Biomedical Nanotechnology, Vol. 15, No. 7, 01.07.2019, p. 1415-1431.

    Research output: Contribution to journalArticle

    TY - JOUR

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    AU - Wu, Jianrong

    AU - Bremner, David H.

    AU - Niu, Shiwei

    AU - Li, Dejian

    AU - Tang, Ranran

    AU - Zhu, Li Min

    PY - 2019/7/1

    Y1 - 2019/7/1

    N2 - The fabrication of theranostic nanoplatforms which combine diagnostic and therapeutic functions have become an emerging approach for personal nanomedicine. Herein, a multifunctional nanoplatform consisting of A7R peptide (ATWLPPR) conjugated hollow mesoporous silica nanoparticles decorated with Ag2S nanodots (Ag2S@HMSs-A7R) has been developed as an efficient theranostic agent for simultaneous photoacoustic (PA) imaging and near-infrared fluorescence imaging (NIRF)-guided targeted chemotherapy and photothermal therapy against human breast cancer MDA-MB-231 cells. The design of Ag2S doped HMSs by in situ controlled growth of ultrasmall Ag2S nanodots in the mesopores of HMSs. The synthesized multifunctional nanoplatform exhibits high doxorubicin (DOX) loading capability (451 mg/g) and can be precisely controlled by glutathione (GSH), acidic environment and external laser irradiation. Thanks to the strong tunable NIR absorbance of Ag2S, the nanoplatform produce effective photoacoustic capacity and superb photothermal conversion under light irradiation, thereby exhibiting sufficient in vivo fluorescence and photoacoustic signals as well as desirable photothermal therapeutic performance. Importantly, A7R peptide can selectively bind the Neuropilin-1 (NRP-1) receptor which overexpressed by the MDA-MB-231 cells. The achieved Ag2S@HMSs-A7R possess ideal imaging capability for both PA and NIRF imaging in vivo, and the anti-tumor effect of Ag2S@HMSs(DOX)-A7R was studied in vitro and in vivo, showing remarkable synergistic chemo-photothermal effect (combination index, CI < 1). Over all, the strategy of utilizing triple-responsive nanocarriers presents a highly promising potential as an efficient method for cancer theranostics.

    AB - The fabrication of theranostic nanoplatforms which combine diagnostic and therapeutic functions have become an emerging approach for personal nanomedicine. Herein, a multifunctional nanoplatform consisting of A7R peptide (ATWLPPR) conjugated hollow mesoporous silica nanoparticles decorated with Ag2S nanodots (Ag2S@HMSs-A7R) has been developed as an efficient theranostic agent for simultaneous photoacoustic (PA) imaging and near-infrared fluorescence imaging (NIRF)-guided targeted chemotherapy and photothermal therapy against human breast cancer MDA-MB-231 cells. The design of Ag2S doped HMSs by in situ controlled growth of ultrasmall Ag2S nanodots in the mesopores of HMSs. The synthesized multifunctional nanoplatform exhibits high doxorubicin (DOX) loading capability (451 mg/g) and can be precisely controlled by glutathione (GSH), acidic environment and external laser irradiation. Thanks to the strong tunable NIR absorbance of Ag2S, the nanoplatform produce effective photoacoustic capacity and superb photothermal conversion under light irradiation, thereby exhibiting sufficient in vivo fluorescence and photoacoustic signals as well as desirable photothermal therapeutic performance. Importantly, A7R peptide can selectively bind the Neuropilin-1 (NRP-1) receptor which overexpressed by the MDA-MB-231 cells. The achieved Ag2S@HMSs-A7R possess ideal imaging capability for both PA and NIRF imaging in vivo, and the anti-tumor effect of Ag2S@HMSs(DOX)-A7R was studied in vitro and in vivo, showing remarkable synergistic chemo-photothermal effect (combination index, CI < 1). Over all, the strategy of utilizing triple-responsive nanocarriers presents a highly promising potential as an efficient method for cancer theranostics.

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    DO - 10.1166/jbn.2019.2729

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