Narratives for drug design

James L. Bown, Alexey Goltsov

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    We explore the role of narratives of complex systems in anti-cancer drug design. We set out the value of narratives relating to cancer in promoting awareness of risky behaviour and in supporting decision-making regarding treatment options. We present cancer as a dysregulated, complex system that has emergent behaviours at multiple scales, and is governed by dynamical spatio-temporal processes. We show that this system changes structure and function in response to anti-cancer drugs, and explain that these changes are sufficiently complex to impede effective drug design. We pose what narrative might offer to support the process of drug design, providing an example of work done to date that might serve as a foundation for narrating complexity. We suggest ways of using this work combined with that of others to begin to consider narrating drug design.
    Original languageEnglish
    Title of host publicationNarrating complexity
    EditorsRichard Walsh, Susan Stepney
    PublisherSpringer
    Chapter18
    Pages253-268
    Number of pages16
    ISBN (Electronic)9783319647142
    ISBN (Print)9783319647128, 3319647121
    DOIs
    Publication statusPublished - 24 Nov 2018

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    Drug Design
    Neoplasms
    Decision Making
    Pharmaceutical Preparations

    Cite this

    Bown, J. L., & Goltsov, A. (2018). Narratives for drug design. In R. Walsh, & S. Stepney (Eds.), Narrating complexity (pp. 253-268). Springer. https://doi.org/10.1007/978-3-319-64714-2
    Bown, James L. ; Goltsov, Alexey. / Narratives for drug design. Narrating complexity. editor / Richard Walsh ; Susan Stepney. Springer, 2018. pp. 253-268
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    Bown, JL & Goltsov, A 2018, Narratives for drug design. in R Walsh & S Stepney (eds), Narrating complexity. Springer, pp. 253-268. https://doi.org/10.1007/978-3-319-64714-2

    Narratives for drug design. / Bown, James L.; Goltsov, Alexey.

    Narrating complexity. ed. / Richard Walsh; Susan Stepney. Springer, 2018. p. 253-268.

    Research output: Chapter in Book/Report/Conference proceedingChapter

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    Bown JL, Goltsov A. Narratives for drug design. In Walsh R, Stepney S, editors, Narrating complexity. Springer. 2018. p. 253-268 https://doi.org/10.1007/978-3-319-64714-2