Nefopam hydrochloride

a fatal overdose

L. Nitin Seetohul*, Giorgia De Paoli, Gail Drummond, Peter D. Maskell

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nefopam is a non-opiate analgesic commonly used for the treatment of moderate to severe pain. A case of a 37-year-old male who was found dead in the morning is presented. An autopsy was performed and femoral venous blood, heart blood, urine, and vitreous humor were submitted for toxicological analysis. A general drug screen detected the presence of nefopam, caffeine, nicotine, citalopram, gabapentin, amitriptyline, diazepam and paracetamol in cardiac blood. Nefopam was quantitated by high-performance liquid chromatography with diode-array detection. Nefopam was found at the following concentrations: 13.6 mg/L in unpreserved femoral blood; 14.7 mg/L in preserved (fluoride-oxalate) femoral blood; 21.2 mg/L in unpreserved cardiac blood and 4.5 mg/L in preserved vitreous. Citalopram was present at a concentration of 0.7 mg/L (femoral blood) and 0.9 mg/L (cardiac blood). Ethanol analyzed by headspace gas chromatography (GC-FID) was detected in preserved (fluoride-oxalate) vitreous (14 mg/100 mL) and preserved (fluoride-oxalate) urine 50 mg/100 mL. Death was attributed to atherosclerotic coronary artery disease and therapeutic drug toxicity.

Original languageEnglish
Pages (from-to)486-489
Number of pages4
JournalJournal of Analytical Toxicology
Volume39
Issue number6
Early online date7 Apr 2015
DOIs
Publication statusPublished - 1 Jul 2015
Externally publishedYes

Fingerprint

Nefopam
Blood
blood
Thigh
Oxalates
oxalate
Fluorides
fluoride
Citalopram
urine
drug
Urine
Nicotine
Caffeine
Vitreous Body
Amitriptyline
High performance liquid chromatography
Acetaminophen
Diazepam
Drug-Related Side Effects and Adverse Reactions

Cite this

Nitin Seetohul, L. ; De Paoli, Giorgia ; Drummond, Gail ; Maskell, Peter D. / Nefopam hydrochloride : a fatal overdose. In: Journal of Analytical Toxicology. 2015 ; Vol. 39, No. 6. pp. 486-489.
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Nitin Seetohul, L, De Paoli, G, Drummond, G & Maskell, PD 2015, 'Nefopam hydrochloride: a fatal overdose', Journal of Analytical Toxicology, vol. 39, no. 6, pp. 486-489. https://doi.org/10.1093/jat/bkv036

Nefopam hydrochloride : a fatal overdose. / Nitin Seetohul, L.; De Paoli, Giorgia; Drummond, Gail; Maskell, Peter D.

In: Journal of Analytical Toxicology, Vol. 39, No. 6, 01.07.2015, p. 486-489.

Research output: Contribution to journalArticle

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AU - Nitin Seetohul, L.

AU - De Paoli, Giorgia

AU - Drummond, Gail

AU - Maskell, Peter D.

PY - 2015/7/1

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N2 - Nefopam is a non-opiate analgesic commonly used for the treatment of moderate to severe pain. A case of a 37-year-old male who was found dead in the morning is presented. An autopsy was performed and femoral venous blood, heart blood, urine, and vitreous humor were submitted for toxicological analysis. A general drug screen detected the presence of nefopam, caffeine, nicotine, citalopram, gabapentin, amitriptyline, diazepam and paracetamol in cardiac blood. Nefopam was quantitated by high-performance liquid chromatography with diode-array detection. Nefopam was found at the following concentrations: 13.6 mg/L in unpreserved femoral blood; 14.7 mg/L in preserved (fluoride-oxalate) femoral blood; 21.2 mg/L in unpreserved cardiac blood and 4.5 mg/L in preserved vitreous. Citalopram was present at a concentration of 0.7 mg/L (femoral blood) and 0.9 mg/L (cardiac blood). Ethanol analyzed by headspace gas chromatography (GC-FID) was detected in preserved (fluoride-oxalate) vitreous (14 mg/100 mL) and preserved (fluoride-oxalate) urine 50 mg/100 mL. Death was attributed to atherosclerotic coronary artery disease and therapeutic drug toxicity.

AB - Nefopam is a non-opiate analgesic commonly used for the treatment of moderate to severe pain. A case of a 37-year-old male who was found dead in the morning is presented. An autopsy was performed and femoral venous blood, heart blood, urine, and vitreous humor were submitted for toxicological analysis. A general drug screen detected the presence of nefopam, caffeine, nicotine, citalopram, gabapentin, amitriptyline, diazepam and paracetamol in cardiac blood. Nefopam was quantitated by high-performance liquid chromatography with diode-array detection. Nefopam was found at the following concentrations: 13.6 mg/L in unpreserved femoral blood; 14.7 mg/L in preserved (fluoride-oxalate) femoral blood; 21.2 mg/L in unpreserved cardiac blood and 4.5 mg/L in preserved vitreous. Citalopram was present at a concentration of 0.7 mg/L (femoral blood) and 0.9 mg/L (cardiac blood). Ethanol analyzed by headspace gas chromatography (GC-FID) was detected in preserved (fluoride-oxalate) vitreous (14 mg/100 mL) and preserved (fluoride-oxalate) urine 50 mg/100 mL. Death was attributed to atherosclerotic coronary artery disease and therapeutic drug toxicity.

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