Nefopam hydrochloride: a fatal overdose

L. Nitin Seetohul*, Giorgia De Paoli, Gail Drummond, Peter D. Maskell

*Corresponding author for this work

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3 Citations (Scopus)

Abstract

Nefopam is a non-opiate analgesic commonly used for the treatment of moderate to severe pain. A case of a 37-year-old male who was found dead in the morning is presented. An autopsy was performed and femoral venous blood, heart blood, urine, and vitreous humor were submitted for toxicological analysis. A general drug screen detected the presence of nefopam, caffeine, nicotine, citalopram, gabapentin, amitriptyline, diazepam and paracetamol in cardiac blood. Nefopam was quantitated by high-performance liquid chromatography with diode-array detection. Nefopam was found at the following concentrations: 13.6 mg/L in unpreserved femoral blood; 14.7 mg/L in preserved (fluoride-oxalate) femoral blood; 21.2 mg/L in unpreserved cardiac blood and 4.5 mg/L in preserved vitreous. Citalopram was present at a concentration of 0.7 mg/L (femoral blood) and 0.9 mg/L (cardiac blood). Ethanol analyzed by headspace gas chromatography (GC-FID) was detected in preserved (fluoride-oxalate) vitreous (14 mg/100 mL) and preserved (fluoride-oxalate) urine 50 mg/100 mL. Death was attributed to atherosclerotic coronary artery disease and therapeutic drug toxicity.

Original languageEnglish
Pages (from-to)486-489
Number of pages4
JournalJournal of Analytical Toxicology
Volume39
Issue number6
Early online date7 Apr 2015
DOIs
Publication statusPublished - 1 Jul 2015
Externally publishedYes

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Nitin Seetohul, L., De Paoli, G., Drummond, G., & Maskell, P. D. (2015). Nefopam hydrochloride: a fatal overdose. Journal of Analytical Toxicology, 39(6), 486-489. https://doi.org/10.1093/jat/bkv036