Neural correlates of finger gnosis

Elena Rusconi, Luigi Tamè, Michele Furlan, Patrick Haggard, Gianpaolo Demarchi, Michela Adriani, Paolo Ferrari, Christoph Braun, Jens Schwarzbach

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Abstract

Neuropsychological studies have described patients with a selective impairment of finger identification in association with posterior parietal lesions. However, evidence of the role of these areas in finger gnosis from studies of the healthy human brain is still scarce. Here we used functional magnetic resonance imaging to identify the brain network engaged in a novel finger gnosis task, the intermanual in-between task (IIBT), in healthy participants. Several brain regions exhibited a stronger blood oxygenation level-dependent (BOLD) response in IIBT than in a control task that did not explicitly rely on finger gnosis but used identical stimuli and motor responses as the IIBT. The IIBT involved stronger signal in the left inferior parietal lobule (IPL), bilateral precuneus (PCN), bilateral premotor cortex, and left inferior frontal gyrus. In all regions, stimulation of nonhomologous fingers of the two hands elicited higher BOLD signal than stimulation of homologous fingers. Only in the left anteromedial IPL (a-mIPL) and left PCN did signal strength decrease parametrically from nonhomology, through partial homology, to total homology with stimulation delivered synchronously to the two hands. With asynchronous stimulation, the signal was stronger in the left a-mIPL than in any other region, possibly indicating retention of task-relevant information. We suggest that the left PCN may contribute a supporting visuospatial representation via its functional connection to the right PCN. The a-mIPL may instead provide the core substrate of an explicit bilateral body structure representation for the fingers that when disrupted can produce the typical symptoms of finger agnosia.
Original languageEnglish
Pages (from-to)9012-9023
Number of pages12
JournalJournal of Neuroscience
Volume34
Issue number27
DOIs
Publication statusPublished - 2 Jul 2014

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Parietal Lobe
Fingers
Brain
Hand
Agnosia
Body Image
Motor Cortex
Prefrontal Cortex
Healthy Volunteers
Magnetic Resonance Imaging

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Rusconi, E., Tamè, L., Furlan, M., Haggard, P., Demarchi, G., Adriani, M., ... Schwarzbach, J. (2014). Neural correlates of finger gnosis. Journal of Neuroscience, 34(27), 9012-9023. https://doi.org/10.1523/JNEUROSCI.3119-13.2014
Rusconi, Elena ; Tamè, Luigi ; Furlan, Michele ; Haggard, Patrick ; Demarchi, Gianpaolo ; Adriani, Michela ; Ferrari, Paolo ; Braun, Christoph ; Schwarzbach, Jens. / Neural correlates of finger gnosis. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 27. pp. 9012-9023.
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Rusconi, E, Tamè, L, Furlan, M, Haggard, P, Demarchi, G, Adriani, M, Ferrari, P, Braun, C & Schwarzbach, J 2014, 'Neural correlates of finger gnosis', Journal of Neuroscience, vol. 34, no. 27, pp. 9012-9023. https://doi.org/10.1523/JNEUROSCI.3119-13.2014

Neural correlates of finger gnosis. / Rusconi, Elena; Tamè, Luigi; Furlan, Michele; Haggard, Patrick; Demarchi, Gianpaolo; Adriani, Michela; Ferrari, Paolo; Braun, Christoph; Schwarzbach, Jens.

In: Journal of Neuroscience, Vol. 34, No. 27, 02.07.2014, p. 9012-9023.

Research output: Contribution to journalArticle

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T1 - Neural correlates of finger gnosis

AU - Rusconi, Elena

AU - Tamè, Luigi

AU - Furlan, Michele

AU - Haggard, Patrick

AU - Demarchi, Gianpaolo

AU - Adriani, Michela

AU - Ferrari, Paolo

AU - Braun, Christoph

AU - Schwarzbach, Jens

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DO - 10.1523/JNEUROSCI.3119-13.2014

M3 - Article

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JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

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ER -

Rusconi E, Tamè L, Furlan M, Haggard P, Demarchi G, Adriani M et al. Neural correlates of finger gnosis. Journal of Neuroscience. 2014 Jul 2;34(27):9012-9023. https://doi.org/10.1523/JNEUROSCI.3119-13.2014