Neurodegenerative diseases and exposure to the environmental metals Mn, Pb, and Hg

Laurent Charlet; Yves Chapron; Peter Faller; Regina Kirsch; Alan T. Stone; Philippe C. Baveye

doi:10.1016/j.ccr.2012.05.012

Neurodegenerative diseases and exposure to the environmental metals Mn, Pb, and Hg

Laurent Charlet, Yves Chapron, Peter Faller, Regina Kirsch, Alan T. Stone, Philippe C. Baveye

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Metal ions appear to play an important role in several neurodegenerative (ND) diseases. Evidence suggests that metal ions bind directly to causative amyloidogenic proteins and modulate their aggregation into amyloids, considered to be a key event in the etiology of ND diseases. Apart from this well-documented binding of essential metals to amyloidogenic proteins, other, non-essential metal ions have been considered to be environmental hazards for neuronal disorders, but tight causative relations have yet to be established. The present article provides a review of the potential role of manganese, lead, and mercury as environmental risk factors in ND diseases, and covers in detail environmental availability of these metals, their uptake and distribution in the body and cells, and their role in Alzheimer's, Parkinson's and Prion diseases.

Original language	English
Pages (from-to)	2147-2163
Number of pages	17
Journal	Coordination Chemistry Reviews
Volume	26
Issue number	19-20
DOIs	https://doi.org/10.1016/j.ccr.2012.05.012
Publication status	Published - Oct 2012

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title = "Neurodegenerative diseases and exposure to the environmental metals Mn, Pb, and Hg",

abstract = "Metal ions appear to play an important role in several neurodegenerative (ND) diseases. Evidence suggests that metal ions bind directly to causative amyloidogenic proteins and modulate their aggregation into amyloids, considered to be a key event in the etiology of ND diseases. Apart from this well-documented binding of essential metals to amyloidogenic proteins, other, non-essential metal ions have been considered to be environmental hazards for neuronal disorders, but tight causative relations have yet to be established. The present article provides a review of the potential role of manganese, lead, and mercury as environmental risk factors in ND diseases, and covers in detail environmental availability of these metals, their uptake and distribution in the body and cells, and their role in Alzheimer's, Parkinson's and Prion diseases.",

author = "Laurent Charlet and Yves Chapron and Peter Faller and Regina Kirsch and Stone, {Alan T.} and Baveye, {Philippe C.}",

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T1 - Neurodegenerative diseases and exposure to the environmental metals Mn, Pb, and Hg

AU - Charlet, Laurent

AU - Chapron, Yves

AU - Faller, Peter

AU - Kirsch, Regina

AU - Stone, Alan T.

AU - Baveye, Philippe C.

PY - 2012/10

Y1 - 2012/10

N2 - Metal ions appear to play an important role in several neurodegenerative (ND) diseases. Evidence suggests that metal ions bind directly to causative amyloidogenic proteins and modulate their aggregation into amyloids, considered to be a key event in the etiology of ND diseases. Apart from this well-documented binding of essential metals to amyloidogenic proteins, other, non-essential metal ions have been considered to be environmental hazards for neuronal disorders, but tight causative relations have yet to be established. The present article provides a review of the potential role of manganese, lead, and mercury as environmental risk factors in ND diseases, and covers in detail environmental availability of these metals, their uptake and distribution in the body and cells, and their role in Alzheimer's, Parkinson's and Prion diseases.

AB - Metal ions appear to play an important role in several neurodegenerative (ND) diseases. Evidence suggests that metal ions bind directly to causative amyloidogenic proteins and modulate their aggregation into amyloids, considered to be a key event in the etiology of ND diseases. Apart from this well-documented binding of essential metals to amyloidogenic proteins, other, non-essential metal ions have been considered to be environmental hazards for neuronal disorders, but tight causative relations have yet to be established. The present article provides a review of the potential role of manganese, lead, and mercury as environmental risk factors in ND diseases, and covers in detail environmental availability of these metals, their uptake and distribution in the body and cells, and their role in Alzheimer's, Parkinson's and Prion diseases.

U2 - 10.1016/j.ccr.2012.05.012

DO - 10.1016/j.ccr.2012.05.012

M3 - Article

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SP - 2147

EP - 2163

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

SN - 0010-8545

IS - 19-20

ER -