Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2147-2163 |
| Number of pages | 17 |
| Journal | Coordination Chemistry Reviews |
| Volume | 26 |
| Issue number | 19-20 |
| DOIs | |
| Publication status | Published - Oct 2012 |
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Neurodegenerative diseases and exposure to the environmental metals Mn, Pb, and Hg. / Charlet, Laurent; Chapron, Yves; Faller, Peter; Kirsch, Regina; Stone, Alan T.; Baveye, Philippe C.
In: Coordination Chemistry Reviews, Vol. 26, No. 19-20, 10.2012, p. 2147-2163.Research output: Contribution to journal › Article
TY - JOUR
T1 - Neurodegenerative diseases and exposure to the environmental metals Mn, Pb, and Hg
AU - Charlet, Laurent
AU - Chapron, Yves
AU - Faller, Peter
AU - Kirsch, Regina
AU - Stone, Alan T.
AU - Baveye, Philippe C.
PY - 2012/10
Y1 - 2012/10
N2 - Metal ions appear to play an important role in several neurodegenerative (ND) diseases. Evidence suggests that metal ions bind directly to causative amyloidogenic proteins and modulate their aggregation into amyloids, considered to be a key event in the etiology of ND diseases. Apart from this well-documented binding of essential metals to amyloidogenic proteins, other, non-essential metal ions have been considered to be environmental hazards for neuronal disorders, but tight causative relations have yet to be established. The present article provides a review of the potential role of manganese, lead, and mercury as environmental risk factors in ND diseases, and covers in detail environmental availability of these metals, their uptake and distribution in the body and cells, and their role in Alzheimer's, Parkinson's and Prion diseases.
AB - Metal ions appear to play an important role in several neurodegenerative (ND) diseases. Evidence suggests that metal ions bind directly to causative amyloidogenic proteins and modulate their aggregation into amyloids, considered to be a key event in the etiology of ND diseases. Apart from this well-documented binding of essential metals to amyloidogenic proteins, other, non-essential metal ions have been considered to be environmental hazards for neuronal disorders, but tight causative relations have yet to be established. The present article provides a review of the potential role of manganese, lead, and mercury as environmental risk factors in ND diseases, and covers in detail environmental availability of these metals, their uptake and distribution in the body and cells, and their role in Alzheimer's, Parkinson's and Prion diseases.
U2 - 10.1016/j.ccr.2012.05.012
DO - 10.1016/j.ccr.2012.05.012
M3 - Article
VL - 26
SP - 2147
EP - 2163
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
SN - 0010-8545
IS - 19-20
ER -