Niosomal drug delivery systems: formulation, preparation and applications

Ali Bagheri, Boon Seang Chu, Harisun Yaakob*

*Corresponding author for this work

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Nonionic surfactant vesicles (niosomes) have drawn a lot of attention in the area of modern drug delivery systems due to their salient features such as biodegradability, biocompatibility, chemical stability, low production cost, easy storage and handling and low toxicity. Niosomes are hydrated vesicular systems having a lamellar bilayer structure formed from nonionic surfactants with or without cholesterol and they are capable of encapsulating bioactive compounds with a wide range of solubility. Niosomes have been evaluated as a carrier for delivery of a number of anti-cancer drugs, genes, antigens and other bioactive compounds. Niosomal systems offer advantages over conventional delivery systems via delivering the bioactives in a controlled/sustained manner and delivering the actives to the target site. Niosomes tackle the problem of insolubility, instability, low bioavailability and rapid degradation of drugs. This paper overviews the general advantages of niosomal systems along with their potential applications in pharmaceutical areas. This article also highlights the effect of niosomal formulation on the physicochemical properties of niosomal systems. Various techniques of preparation are detailed and some down-sizing approaches have been identified.

Original languageEnglish
Pages (from-to)1671-1685
Number of pages15
JournalWorld Applied Sciences Journal
Volume32
Issue number8
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Liposomes
Nonionic surfactants
Solubility
Pharmaceutical Preparations
Biodegradability
Chemical stability
Biocompatibility
Toxicity
Genes
Cholesterol
Antigens
Degradation
Drug Delivery Systems
Costs

Cite this

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title = "Niosomal drug delivery systems: formulation, preparation and applications",
abstract = "Nonionic surfactant vesicles (niosomes) have drawn a lot of attention in the area of modern drug delivery systems due to their salient features such as biodegradability, biocompatibility, chemical stability, low production cost, easy storage and handling and low toxicity. Niosomes are hydrated vesicular systems having a lamellar bilayer structure formed from nonionic surfactants with or without cholesterol and they are capable of encapsulating bioactive compounds with a wide range of solubility. Niosomes have been evaluated as a carrier for delivery of a number of anti-cancer drugs, genes, antigens and other bioactive compounds. Niosomal systems offer advantages over conventional delivery systems via delivering the bioactives in a controlled/sustained manner and delivering the actives to the target site. Niosomes tackle the problem of insolubility, instability, low bioavailability and rapid degradation of drugs. This paper overviews the general advantages of niosomal systems along with their potential applications in pharmaceutical areas. This article also highlights the effect of niosomal formulation on the physicochemical properties of niosomal systems. Various techniques of preparation are detailed and some down-sizing approaches have been identified.",
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}

Niosomal drug delivery systems : formulation, preparation and applications. / Bagheri, Ali; Chu, Boon Seang; Yaakob, Harisun.

In: World Applied Sciences Journal, Vol. 32, No. 8, 2014, p. 1671-1685.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Niosomal drug delivery systems

T2 - formulation, preparation and applications

AU - Bagheri, Ali

AU - Chu, Boon Seang

AU - Yaakob, Harisun

PY - 2014

Y1 - 2014

N2 - Nonionic surfactant vesicles (niosomes) have drawn a lot of attention in the area of modern drug delivery systems due to their salient features such as biodegradability, biocompatibility, chemical stability, low production cost, easy storage and handling and low toxicity. Niosomes are hydrated vesicular systems having a lamellar bilayer structure formed from nonionic surfactants with or without cholesterol and they are capable of encapsulating bioactive compounds with a wide range of solubility. Niosomes have been evaluated as a carrier for delivery of a number of anti-cancer drugs, genes, antigens and other bioactive compounds. Niosomal systems offer advantages over conventional delivery systems via delivering the bioactives in a controlled/sustained manner and delivering the actives to the target site. Niosomes tackle the problem of insolubility, instability, low bioavailability and rapid degradation of drugs. This paper overviews the general advantages of niosomal systems along with their potential applications in pharmaceutical areas. This article also highlights the effect of niosomal formulation on the physicochemical properties of niosomal systems. Various techniques of preparation are detailed and some down-sizing approaches have been identified.

AB - Nonionic surfactant vesicles (niosomes) have drawn a lot of attention in the area of modern drug delivery systems due to their salient features such as biodegradability, biocompatibility, chemical stability, low production cost, easy storage and handling and low toxicity. Niosomes are hydrated vesicular systems having a lamellar bilayer structure formed from nonionic surfactants with or without cholesterol and they are capable of encapsulating bioactive compounds with a wide range of solubility. Niosomes have been evaluated as a carrier for delivery of a number of anti-cancer drugs, genes, antigens and other bioactive compounds. Niosomal systems offer advantages over conventional delivery systems via delivering the bioactives in a controlled/sustained manner and delivering the actives to the target site. Niosomes tackle the problem of insolubility, instability, low bioavailability and rapid degradation of drugs. This paper overviews the general advantages of niosomal systems along with their potential applications in pharmaceutical areas. This article also highlights the effect of niosomal formulation on the physicochemical properties of niosomal systems. Various techniques of preparation are detailed and some down-sizing approaches have been identified.

U2 - 10.5829/idosi.wasj.2014.32.08.848

DO - 10.5829/idosi.wasj.2014.32.08.848

M3 - Review article

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VL - 32

SP - 1671

EP - 1685

JO - World Applied Sciences Journal

JF - World Applied Sciences Journal

SN - 1818-4952

IS - 8

ER -